Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism

Volumn 489, Issue 1, 1977, Pages 119-125

  Kuroda, Masao ^a   Tanzawa, Kazuhiko ^a   Tsujita, Yoshio ^a   Endo, Akira ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ML 236 B; TYLOXAPOL; UNCLASSIFIED DRUG;

CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; HYPERLIPIDEMIA; INTRAVENOUS DRUG ADMINISTRATION; LIPOGENESIS; LIVER; RAT; THEORETICAL STUDY;

ACETATES; AMMONIUM COMPOUNDS; ANIMAL; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; FATTY ACIDS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPERLIPIDEMIA; LIVER; MALE; NAPHTHALENES; POLYETHYLENE GLYCOLS; PYRANS; RATS; STEROLS; TRIGLYCERIDES;

EID: 0017724648     PISSN: 00052760     EISSN: None     Source Type: Journal    
DOI: 10.1016/0005-2760(77)90238-7     Document Type: Article

References (23)

1. Effect of triton on lipoprotein lipase of rat plasma.
2. THE PATHOGENESIS OF HYPERLIPEMIA INDUCED BY MEANS OF SURFACE-ACTIVE AGENTS: II. FAILURE OF EXCHANGE OF CHOLESTEROL BETWEEN THE PLASMA AND THE LIVER IN RABBITS GIVEN TRITON WR 1339
3. ACCELERATION OF HEPATIC CHOLESTEROL SYNTHESIS BY TRITON WR-1339
4. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.