Inhibitory Effect of Abrin and Ricin on the Growth of Transplantable Murine Tumors and of Abrin on Human Cancers in Nude Mice

Cancer Research

Volumn 37, Issue 12, 1977, Pages 4559-4567

  Olsnes, Sjur ^a   Pihl, Alexander ^a  

^a STATOIL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYLTRYPTOPHAN; RICIN;

ABRIN A; ASCITES; BLOOD; BONE MARROW DEPRESSION; CANCER CELL; CANCER CHEMOTHERAPY; CANCER GRAFT; CANCER GROWTH; CANCER TRANSPLANTATION; CELL CULTURE; DRUG BLOOD LEVEL; DRUG RESISTANCE; DRUG SENSITIVITY; EHRLICH ASCITES TUMOR; EWING SARCOMA; FIBROSARCOMA; HELA CELL; HISTOLOGY; HUMAN; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE; LEWIS CARCINOMA; LUNG CARCINOMA; MELANOMA; MELANOMA B16; MOUSE; NORMAL HUMAN; NUDE MOUSE; OVARY CARCINOMA; OVARY SARCOMA; PROTEIN SYNTHESIS; SURVIVAL; THEORETICAL STUDY;

ABRIN; ANIMAL; CELL LINE; COMPARATIVE STUDY; CYCLOPHOSPHAMIDE; FEMALE; HUMAN; LEUKOPENIA; MALE; MELANOMA; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; PLANT PROTEINS; RICIN; SARCOMA, EXPERIMENTAL; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 0017698481     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Benson, S., Olsnes, S., Pihl, A., Skorve, J., and Abraham, A. K. On the Mechanism of Protein Synthesis Inhibition by Abrin and Ricin. Inhibition of the GTP Hydrolysis Site on the 60S Ribosomal Subunit. European J. Biochem., 59: 573–580, 1975.
2. Corbett, T. H., Griswold, D. P., Mayo, J. G., Laster, W. R., and Schabel, F. M., Jr. Cyclophosphamide-Adriamycin Combination Chemotherapy of Transplantable Murine Tumors. Cancer Res., 35: 1568-1573, 1975.
3. Davy, M., Brustad, T., and Mossige, J. Irradiation of Human Ovarian Tumors in Nude Mice. Proceedings of the Second International Workshop on Nude Mice. University of Tokyo Press, Tokyo: in press.
4. Fodstad, ⊘., Olsnes, S., and Pihl, A. Toxicity, Distribution and Elimination of the Cancerostatic Lectins Abrin and Ricin after Parenteral Injection into Mice. Brit. J. Cancer, 34: 418–424, 1976.
5. Giovanella, B. C., Stehlin, J. S., and Williams, L. J., Jr. Heterotransplantation of Human Malignant Tumors in “Nude” Thymusless Mice. II. Malignant Tumors Induced by Injection of Cell Cultures Received from Human Solid Tumors. J. Natl. Cancer Inst., 52: 921–930, 1974.
6. Gürtler, L., and Steinhoff, D. Hemmung des Tumorwachstums durch Lectin aus der Bohne von Ricinus communis. Z. Physiol. Chem., 353: 1521, 1972.
7. Hsu, C.-T., Lin, J.-Y., and Tung, T.-C. Further Report on Therapeutic Effect of Abrin and Ricin on Human Cancers. J. Formosan Med. Assoc., 73: 526–542, 1974.
8. Johnson, R. K., Inouye, T., Goldin, A., and Stark, G. R. Antitumor Activity of N-(Phosphonacetyl)-L-aspartic Acid, a Transition-State Inhibitor of Aspartate Transcarbamylase. Cancer Res., 36: 2720–2725, 1976.
9. Lin, J.-Y., Lin, L.-T., Chen, C.-C., Tserng, K.-Y., and Tung, T.-C. The Inhibitory Effect of Crystalline Ricine on Ehrlich Ascites Cells. J. Formosan Med. Assoc., 69: 53–57, 1970.
10. Lin, J.-Y., Tserng, K.-Y., Chen, C.-C., Lin, L.-T., and Tung, T.-C. Abrin and Ricin: New Anti-tumor Substances. Nature, 227, 292–293, 1970.
11. Mayo, J. G., Laster, W. R., Jr., Andrews, C. M., and Schabel, F. M., Jr. Success and Failure in the Treatment of Solid Tumors. III. “Cure” of Metastatic Lewis Lung Carcinoma with Methyl-CCNU (NSC-95441). Cancer Chemotherapy Rept., 56: 183–195, 1972.
12. Meager, A., Ungkitchanukit, A., and Hughes, R. C. Variants of Hamster Fibroblasts Resistant to Ricinus communis Toxin (Ricin). Biochem. J., 154: 113–124, 1976.
13. Meager, A., Ungkitchanukit, A., Nairn, R., and Hughes, R. C. Ricin Resistance of Baby Hamster Kidney Cells. Nature, 257: 137–139, 1975.
14. Mosinger, M. Sur les Reactions Neuro-endocriniennes et Génitales dans L'intoxication Par la Ricine. Compt. Rend., 145: 738–740, 1951.
15. Nicolson, G. L., Lacorbiere, M., and Hunter, T. R. Mechanism of Cell Entry and Toxicity of an Affinity-Purified Lectin from Ricinus communis and Its Differential Effects on Normal and Virus Transformed Fibroblasts. Cancer Res., 35: 144–155, 1975.
16. Ohsawa, N., Veyama, Y., Morita, K., and Kondo, Y. Heterotransplantation of Human Functioning Tumors to Nude Mice. Proceedings of the Second International Workshop on Nude Mice. University of Tokyo Press, Tokyo: in press.
17. Olsnes, S., Fernandez-Puentes, C., Carrasco, L., and Vazquez, D. Ribosome Inactivation by the Toxic Lectins Abrin and Ricin. Kinetics of the Enzymatic Activity of the Toxin A-Chains. European. J. Biochem., 60: 281–288, 1975.
18. Olsnes, S., and Pihl, A. Treatment of Abrin and Ricin with β-Mercaptoethanol. Opposite Effects on Their Toxicity in Mice and Their Ability to Inhibit Protein Synthesis in a Cell-free System. Federation European Biochem. Soc. Letters, 28: 48–50, 1972.
19. Olsnes, S., and Pihl, A. Different Biological Properties of the Two Constituent Peptide Chains of Ricin. A Toxic Protein Inhibiting Protein Synthesis. Biochemistry, 12: 3121–3126, 1973.
20. Olsnes, S., and Pihl, A. Isolation of Properties of Abrin: A Toxic Protein Inhibiting Protein Synthesis. Evidence for Different Biological Functions of Its Two Constituent Peptide Chains. European J. Biochem., 35: 179–185, 1973.
21. Olsnes, S., Refsnes, K., and Pihl, A. Mechanism of Action of the Toxic Lectins Abrin and Ricin. Nature, 249: 627–631, 1974.
22. Olsnes, S., Sandvig, L., Refsnes, K., and Pihl, A. Rates of Different Steps Involved in the Inhibition of Protein Synthesis by the Toxic Lectins Abrin and Ricin. J. Biol. Chem., 251: 3985–3992, 1976.
23. Povlsen, C. O., Jacobsen, G. K., and Rygaard, J. The Mouse Mutant Nude as a Model for Testing of Anticancer Agents. In: 5th ICLA Symposium. Stuttgart: Gustav Fischer Verlag, 1973.
24. R) on a Burkitt's Lymphoma Serially Grown in Nude Mice. In: Proceedings of the First International Workshop on Nude Mice, pp. 285–292. Stuttgart: Gustav Fischer Verlag, 1974.
25. Povlsen, C. O., Visfeldt, J., Rygaard, J., and Jensen, G. Growth Patterns and Chromosome Constitutions of Human Malignant Tumors after Longterm Serial Transplantation in Nude Mice. Acta Pathol. Microbiol. Scand. A, 83: 709–716, 1975.
26. Reddy, V. V. S., Choudry, J. N., Vadlamudi, S., Waravdekor, V. S., and Goldin, A. Antileukemic and lmmunosuppressive Properties of Abrin and Ricin. Federation Proc., 32: Abstr. 2936, 1973.
27. Reddy, V. V., and Sirsi, M. effect of Abrus precatorius L. on Experimental Tumors. Cancer Res., 29: 1447–1451, 1969.
28. Sandvig, K., Olsnes, S., and Pihl, A. Kinetics of Binding of the Toxic Lectins Abrin and Ricin to Surface Receptors of Human Cells. J. Biol. Chem., 251: 3877–3984, 1976.
29. Shimosato, Y., Kameya, T., Nagai, K., Hirohashi, S., Koide, T., Hayashi, H., and Nomura, T. Transplantation of Human Tumors in Nude Mice. J. Natl. Cancer Inst., 56: 1251–1255, 1976.
30. Sperti, S., Montanaro, L., Mattiolo, A., and Stirpe, F. Inhibition by Ricin and Protein Synthesis in Vitro. 60S Ribosomal Subunits as Target of the Toxins. Biochem. J., 136: 813–815, 1973.
31. Tarnowski, G. S., Schmid, F. A., Capuccino, J. G., and Stock, C. C. Chemotherapy Studies in an Animal Tumor Spectrum. II. Sensitivity of Tumors to Fourteen Antitumor Agents. Cancer Res., 26: 181-207, 1966.
32. Tung, T.-C., Hsu, C.-T., and Lin, J.-Y. Therapeutic Effect of Abrin and Ricin on Human Cancers. J. Formosan Med. Assoc., 70: 569-578, 1971.