Estimation of population characteristics of pharmacokinetic parameters from routine clinical data

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 5, Issue 5, 1977, Pages 445-479

  Sheiner, Lewis B ^a   Rosenberg, Barr ^b   Marathe, Vinay V ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

maximum likelihood; parameter estimation; population parameters; statistics

Indexed keywords

DIGOXIN;

MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; MODEL; NONBIOLOGICAL MODEL; PHARMACOKINETICS; POPULATION; STATISTICS; THEORETICAL STUDY;

HUMAN; KINETICS; PHARMACEUTICAL PREPARATIONS; POPULATION; REFERENCE VALUES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017688679     PISSN: 0090466X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/BF01061728     Document Type: Article

References (38)

1. Modelling of individual pharmacokinetics for computer-aided drug dosage
2. Computerassisted digoxin therapy
3. Improved computer-assisted digoxin therapy
4. A new simple and rapid method to monitor the renal function based on pharmacokinetic consideration of endogenous creatinine
5. A computer program for estimation of creatinine clearance from unstable serum creatinine levels, age, sex, and weight
6. Determinants of the renal clearance of digoxin
7. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay
8. Digitalis assay and its clinical application: Symposium on Cardiac Rhythm Disturbances. I
9. Role of pharmacokinetics in drug dosage adjustment. I. Pharmacologic effect kinetics and apparent volume of distribution of digoxin
10. Pharmacokinetic design of digoxin dosage regimens in relation to renal function
11. Instructional goals for physicians in the use of blood level data-and the contribution of computers
12. Digoxin pharmacokinetics: Role of renal failure in dosage regimen design
13. Comparison of five radioimmunoassays and enzyme bioassay for measurement of digoxin in blood
14. Variability of standard curves in radioimmunoassay of plasma digoxin
15. Equivalence lack in digoxin plasma levels
16. Absorption of orally given digoxin preparations
17. Intersubject variation in absorption of digoxin in normal volunteers
18. Digoxin
19. Loading and maintenance doses of digoxin in patients with normal renal function and those with severely impaired renal function
20. Pharmacokinetics of digoxin: Comparison of a twoand a three-compartment model in man
21. Intravenous digoxin as a bioavailability standard: Slow infusion and rapid injection
22. Digoxin metabolism in the elderly
23. A mathematical analysis of digitalis kinetics in patients with normal and reduced renal function
24. Studies with tritiated digoxin in human subjects after intravenous administration
25. Renal tubular secretion of digoxin
26. Studies following intramuscular tritiated digoxin in human subjects
27. Pharmacokinetic data
28. Studies with tritiated digoxin in renal failure
29. Relationship of the excretion of tritiated digoxin to renal function
30. Differences in serum digoxin concentrations between outpatients and inpatients: An effect of compliance?
31. Digoxin pharmacokinetics: Multicompartmental analysis and its clinical implications
32. Correlation of plasma levels of digoxin in cardiac patients with dose and measures of renal function