Relationship between Effects on Nucleic Acid Synthesis in Cell Cultures and Cytotoxicity of 4-Demethoxy Derivatives of Daunorubicin and Adriamycin

Cancer Research

Volumn 37, Issue 12, 1977, Pages 4523-4528

  Dasdia, T ^b   Casazza, A M ^b   Marco, A Di ^b  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 DEMETHOXY 7,9 DIEPIDAUNORUBICIN; 4 DEMETHOXYDOXORUBICIN; DAUNORUBICIN; DOXORUBICIN; EPIDOXORUBICIN DERIVATIVE; IDARUBICIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CYTOTOXICITY; DNA SYNTHESIS; DOSE RESPONSE; DRUG COMPARISON; DRUG RESPONSE; EMBRYO; FIBROBLAST; HELA CELL; IN VITRO STUDY; LIPOPHILICITY; MOUSE; NUCLEIC ACID SYNTHESIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

CELL SURVIVAL; CELLS, CULTURED; DAUNORUBICIN; DNA; DOXORUBICIN; RNA; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE; URIDINE;

EID: 0017667933     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Arcamone, F., Bernardi, L., Giardino, L., Patelli, B., Di Marco, A., Casazza, A. M., Pratesi, G., and Reggiani, P. Synthesis and Antitumor Activity of 4-Demethoxydaunorubicin, 4-Demethoxy-7, 9-diepi-daunorubicin, and Their ß Anomers. Cancer Treat. Rept., 60: 829–834, 1976.
2. Arcamone, F., Franceschi, G., Minghetti, A., Penco, S., Redaelli, S., Di Marco, A., Casazza, A. M., Dasdia, T., Di Fronzo, G., Giuliani, F., Lenaz, L., Necco, A., and Soranzo, C. Synthesis and Biological Evaluation of Some 14-O-Acyl Derivatives of Adriamycin. J. Med. Chem., 17: 335–337, 1974.
3. Arcamone, F., Penco, S., Vigevani, A., Redaelli, S., Franchi, G., Di Marco, A., Casazza, A. M., Dasdia, T., Formelli, F., Necco, A., and Soranzo, C. Synthesis and Antitumor Properties of New Glycosides of Daunomycinone and Adriamycinone. J. Med. Chem., 18: 703-707, 1975.
4. Bachur, N. R., Steele, M., Meriwether, W. D., and Hildebrand, R. C. Cellular Pharmacodynamics of Several Anthracycline Antibiotics. J. Med. Chem., 19: 651–654, 1976.
5. Barranco, S. C., and Novak, J. K. Survival Responses of Dividing and Nondividing Mammalian Cells after Treatment with Hydroxyurea, Arabinosylcytosine, or Adriamycin. Cancer Res., 34: 1616–1618, 1974.
6. Di Marco, A. Adriamycin (NSC-123127): Mode and Mechanism of Action. Cancer Chemotherapy Rept., 6 (Part 3): 91–106, 1975.
7. Di Marco, A., Arcamone, F., and Zunino, F. Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action. In: J. W. Corcoran and F. E. Hahn (eds.), Antibiotics, Vol. 3, pp. 101–128. Berlin: Springer-Verlag, 1974.
8. Di Marco, A., Casazza, A. M., Gambetta, R., Supino, R., and Zunino, F. Relationship between Activity and Amino Sugar Stereochemistry of Daunorubicin and Adriamycin Derivatives. Cancer Res., 36: 1962–1966, 1976.
9. Gosalvez, M., and Blanco, M. Inhibition of Na-K ATPase by the Antitumor Antibiotic Adriamycin. In: Abstracts: Fifth International Biophysic Congress, Copenhagen, August 4 to 9, 1975.
10. Iwamoto, Y., Hansen, I. L., Porter, T. H., and Folkers, K. Inhibition of Coenzyme Qurenzymes, Succinoxidase and NADH-oxidase, by Adriamycin and Other Quinones Having Antitumor Activity. Biochem. Biophys. Res. Commun., 58: 633–638, 1974.
11. Kim, S. H., and Kim, J. H. Lethal Effect of Adriamycin on the Division Cycle of HeLa Cells. Cancer Res., 32: 323–325, 1972.
12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. Protein Measurement with the Folin Phenol Reagent. J. Biol. Chem., 193: 265–275, 1951.
13. Massimo, L., Dagna-Bricarelli, F., and Cherchi, M. G. Effects of Adriamycin on Blastogenesis and Chromosomes of Blood Lymphocytes: in Vitro and in Vivo Studies. In: S. K. Carter, A. Di Marco, M. Ghione, I. H. Krakoff, and G. Mathé (eds.), International Symposium on Adriamycin, pp. 35–46. Berlin: Springer-Verlag, 1972.
14. Murphree, S. A., Cunningham, L. S., Hwang, K. M., and Sartorelli, A. C. Effects of Adriamycin on Surface Properties of Sarcoma 180 Ascites Cells. Biochem. Pharmacol. 25: 1227–1231, 1976.
15. Necco, A., Dasdia, T., Cozzi, S., and Ferraguti, M. Ultrastructural Changes Produced in Cultured Adriamycin-treated Myocardial Cells. Tumori, 62: 537–544, 1976.
16. Necco, A., Dasdia, T., Di Francesco, D., and Ferroni, A. Action of Ouabain. Oligomycin, and Glucagon on Cultured Heart Cells Treated with Adriamycin. Pharmacol. Res. Commun. 8: 105–109, 1976.
17. Noel, G., Trouet, A., Zenebergh, A., and Tulkens, P. Comparative Cell Pharmacokinetics of Daunomycin and Adriamycin. In: M. Staquet, H. Tagnon, Y. Kenis, G. Bonadonna, S. K. Carter, G. Sokel, A. Trouet, M. Ghione, C. Praga, L. Lenaz, and O. S. Karim (eds.), Adriamycin Review, pp. 99–105. Ghent, Belgium: European Press Medikon, 1975.
18. Schwartz, H. S. DNA Breaks in P288 Tumor Cells in Mice after Treatment with Daunorubicin and Adriamycin. Res. Commun. Chem. Pathol. Pharmacol., 10: 51–64, 1975.
19. Schwartz, H. S. Mechanism and Selectivity of Anthracyclines, Aminogly-cosides and Other Intercalating Agents. Biomedicine, 24: 317-323, 1976.
20. Stacher, A., Novotny, H., Ruzicko, F., and Schufried, G. Chromosomal Aberration Due to Cytostatic Agents. Intern. J. Clin. Pharmacol. Biopharm., 4: 250–257, 1974.
21. Supino, R., Casazza, A. M., and Di Marco, A. Effect of Daunorubicin and Adriamycin on Nucleic Acid Synthesis of Serum Stimulated Mouse Embryo Fibroblasts. Tumori, 63: 31–41, 1977.
22. Todaro, G. J., Lazar, G. K., and Green, H. The Initiation of Cell Division in a Contact Inhibited Mammalian Cell Line. J. Cellular Comp. Physiol., 66: 325–333, 1965.
23. Twentyman, P. R., and Bleehen, N. M. Changes in Sensitivity to Cytotoxic Agent Occurring during the Life-history of Monolayer Cultures of a Mouse Tumour Cell Line. Brit. J. Cancer, 31: 417–423, 1975.
24. Vig, B. K. Chromosome Aberrations Induced in Human Leukocytes by the Antileukemic Antibiotic Adriamycin. Cancer Res., 31: 32-38, 1971.
25. Zunino, F., Gambetta, R., Di Marco, A., Luoni, G., and Zaccara, A. Effects of the Stereochemical Configuration on the Interaction of Some Daunomycin Derivatives with DNA. Biochem. Biophys. Res. Commun., 69: 744–750, 1976.