Visualization of drug-nucleic acid interactions at atomic resolution. III. Unifying structural concepts in understanding drug-DNA interactions and their broader implications in understanding protein-DNA interactions

Journal of Molecular Biology

Volumn 114, Issue 3, 1977, Pages 333-365

  Sobell, Henry M ^a,b   Tsai, Chun Che ^a,b   Jain, Shri C ^a,b   Gilbert, Steven G ^a,b  

^a Department of Chemistry ^*  (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DACTINOMYCIN; DNA; ETHIDIUM BROMIDE; PROTEIN; RNA POLYMERASE;

COMPUTER ANALYSIS; DRUG COMPARISON; DRUG INTERACTION; DRUG PROTEIN BINDING; ETHIDIUM CHLORIDE; IREHDIAMINE; MODEL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DACTINOMYCIN; DIAMINES; DNA; DNA, SUPERHELICAL; DRUG INTERACTIONS; ETHIDIUM; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017642366     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(77)90254-6     Document Type: Article

References (40)

1. Least-squares refinement of the crystal and molecular structures of DNA and RNA from X-ray data and standard bond lengths and angles
2. Studies of the binding of actinomycin and related compounds to DNA
3. Stereochemistry of nucleic acids and their constituents. IV. Allowed and preferred conformations of nucleosides, nucleoside mono-, di-, tri-, tetraphosphates, nucleic acids and polynucleotides
4. Visualization of drug-nucleic acid interactions at atomic resolution