2-Deaminoactinomycin D, Synthesis and Interaction with Deoxyribonucleic Acid

Journal of Medicinal Chemistry

Volumn 20, Issue 8, 1977, Pages 1055-1059

  Mosher, Carol W ^a   Kuhlmann, Karl F ^a   Kleid, Dennis G ^a   Henry, David W ^a  

^a SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOMYCIN DERIVATIVE; DACTINOMYCIN; DNA;

CIRCULAR DICHROISM; DACTINOMYCIN DERIVATIVE; DRUG ANALYSIS; DRUG COMPARISON; DRUG COMPETITION; DRUG IDENTIFICATION; DRUG INTERACTION; DRUG METABOLISM; DRUG SYNTHESIS; DRUG TOXICITY; IN VITRO STUDY; LEUKEMIA; LEUKEMIA L 1210; LEUKEMIA P 388; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID SYNTHESIS; SPECTROMETRY; THEORETICAL STUDY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMAL; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; CIRCULAR DICHROISM; DACTINOMYCIN; DEAMINATION; DEPRESSION, CHEMICAL; DNA; DNA, BACTERIAL; DNA, CIRCULAR; DNA, NEOPLASM; ESCHERICHIA COLI; IN VITRO; LEUKEMIA L1210; LEUKEMIA, EXPERIMENTAL; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; RNA, NEOPLASM; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017640030     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00218a013     Document Type: Article

References (34)

1. S. Farber, J. Am. Med. Assoc., 198, 826 (1966)
2. J. L. Lewis, Jr., Cancer, 30, 1517 (1972)
3. E. Frei, III, Cancer Chemother. Rep., 58, 49 (1974)
4. G. Hartmann, U. Coy, and G. Kniese, Z. Physiol. Chem., 330, 227 (1963)
5. J. M. Kirk, Biochim. Biophys. Acta, 42, 167 (1960)
6. J. Hurwitz, T. J. Furth, M. Malamy, and M. Alexander, Proc. Natl. Acad. Sci. U.S.A., 48, 1222 (1962)
7. E. Reich, R. M. Franklin, A. J. Shatkin, and E. L. Tatum, Science, 134, 556 (1961)
8. I. H. Goldberg, M. Rabinowitz, and E. Reich, Proc. Natl. Acad. Sci. U.S.A., 48, 2094 (1962)
9. W. Müller and D. M. Crothers, J. Mol. Biol., 35, 251 (1968)
10. H. M. Sobell and S. C. Jain, J. Mol. Biol., 68, 21 (1972)
11. M. Waring, J. Mol. Biol., 54, 247 (1970)
12. H. Brockmann, H. Gröne, and G. Pampus, Chem. Ber., 91, 1916 (1958)
13. S. Moore, M. Kondo, M. Copeland, J. Meienhofer, and R. K. Johnson, J. Med. Chem., 18, 1098 (1975)
14. H. Brockmann, P. Hocks, and W. Müller, Chem. Ber., 100, 1051 (1967)
15. H. Brockmann, G. Pampus, and R. Mecke, Chem. Ber., 92, 3082 (1959)
16. H. Brockmann and B. Franck, Chem. Ber., 87, 1767 (1954)
17. M. Waring, Nature (London), 219, 1320 (1968)
18. H. Lackner, Tetrahedron Lett., 2221 (1971)
19. H. Lackner, Angew. Chem., Int. Ed. Engl., 14, 375 (1975)
20. F. Ascoli, P. DeSantis, M. Lener, and M. Savino, Biopolymers, 11, 1173 (1972)
21. C. W. Mosher and L. Goodman, J. Org. Chem., 37, 2928 (1972)
22. W. Keller, Proc. Natl. Acad. Sci. U.S.A., 72, 4876 (1975)
23. M. J. Waring, Biochem. J., 109, 28P (1968)
24. J. C. Wang, Biochim. Biophys. Acta, 232, 246 (1971)
25. L. S. Lerman, J. Mol. Biol., 3, 18 (1961)
26. J. C. Wang, J. Mol. Biol., 89, 783 (1974)
27. W. F. Raub, Fed. Proc., Fed. Am. Soc. Exp. Biol., 33, 2390 (1974)
28. G. Tong, W. W. Lee, D. R. Black, and D. W. Henry, J. Med. Chem., 19, 395 (1976)
29. R. L. Rodriguez, F. Bolivar, H. M. Goodman, H. W. Boyer, and M. Betlach, “Molecular Mechanisms in the Control of Gene Expression”, Academic Press, New York, N.Y., 1976, p 471
30. Y. M. Kupersztoch-Portnoy, M. A. Lovett, and D. R. Helinski, Biochemistry, 13, 5484 (1974)
31. J. C. Wang, J. Mol. Biol., 55, 523 (1971)
32. W. Keller and J. Wendell, Cold Spring Harbor Symp. Quant. Biol., 39, 199 (1975)
33. R. E. Depew and J. C. Wang, Proc. Natl. Acad. Sci. U.S.A., 72, 4275 (1975)
34. D. E. Pulleyblank, M. Shure, D. Tang, J. Vinograd, and H.-P. Vosberg, Proc. Natl. Acad. Sci. U.S.A., 72, 4280 (1975)