Effect of enterohepatic circulation on the pharmacokinetics of spironolactone in man

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 300, Issue 3, 1977, Pages 281-287

  Abshagen, U ^a   von Grodzicki, U ^a   Hirschberger, U ^a   Rennekamp, H ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Enterohepatic circulation; Metabolism; Pharmacokinetics; Spironolactone; Urinary excretion

Indexed keywords

SPIRONOLACTONE; CANRENONE; RADIOISOTOPE; REAGENT;

ADULT; AGED; ARTICLE; BILE; BLOOD; ENTEROHEPATIC CIRCULATION; FEMALE; HALF LIFE TIME; HUMAN; KINETICS; MALE; METABOLISM; TIME; URINE; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; SPIRONOLACTONE H 3; SULFOXIDATION; THEORETICAL STUDY;

AGED; BILE; ENTEROHEPATIC CIRCULATION; FEMALE; HALF-LIFE; HUMAN; KINETICS; MALE; MIDDLE AGE; SPIRONOLACTONE; TIME FACTORS;

EID: 0017624810     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/BF00500971     Document Type: Article

References (12)

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3. Disposition kinetics of spironolactone in hepatic failure after single doses and prolonged treatment
4. First pass metabolism of 35S-perazine in the rat jejunal loop
5. The enzymatic formation of sulfoxides: The oxidation of chlorpromazine and 4,4′-diaminodiphenyl-sulfide by guinea pig liver microsomes
6. Isolation and identification of novel sulfur containing metabolites of spironolactone (Aldactone®)
7. Formation of chlorpromazine sulphoxide and monodesmethyl-chlorpromazine by microsomes of small intestine
8. Preparation of metabolites of spironolactone by microbial oxygenation
9. Plasma levels of spironolactone in the dog
10. Pharmacokinetics of spironolactone, canrenone and canrenoate-K in humans
11. Conversion of spironolactone and disposition kinetics of spironolactone and canrenoate-potassium in rats