Synthesis and Antitumor Properties of Bis(quinaldine) Derivatives

Journal of Medicinal Chemistry

Volumn 20, Issue 11, 1977, Pages 1528-1531

  Sinha, Birandra K ^a   Philen, R M ^a   Sato, R ^a   Cysyk, R L ^b  

^a Microbiological Associates Inc   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASES; QUINALDINE DERIVATIVE; QUINOLINE DERIVATIVE; BIS[OMEGA(2 METHYL 4 QUINOLINYL)AMINO]ALKYLAMINE DERIVATIVE; N,N' BIS(2 METHYL 4 QUINOLINYL) 1,OMEGA ALKANEDIAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; EXPERIMENTAL LEUKEMIA; LYMPHATIC LEUKEMIA; METABOLISM; SYNTHESIS; DOSE RESPONSE; DRUG ANALYSIS; DRUG BINDING; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG INTERACTION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; INFRARED SPECTROMETRY; LEUKEMIA P 388; MASS SPECTROMETRY; MOUSE; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

ANIMAL; ANTINEOPLASTIC AGENTS; DNA; DNA-DIRECTED RNA POLYMERASES; LEUKEMIA, EXPERIMENTAL; LEUKEMIA, LYMPHOCYTIC; QUINALDINES; QUINOLINES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017623252     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00221a037     Document Type: Article

References (23)

1. E. S. Canellakis, NCI 4th Joint Working Conference, Hunt Valley, Md., 1973.
2. E. S. Canellakis, R. M. Fico, A. J. Sarris, and Y. H. Shaw.
3. Biochem. Pharmacol., 25, 231 (1976).
4. J. B. Le Pecq, M. Le Bret, J. Barbet, and B. Roques, Proc. Natl. Acad. Sci. U.S.A., 72 (8), 2915 (1975).
5. R. U. Schock, J. Am. Chem. Soc., 79, 1672 (1957).
6. C. R. Hauser and G. A. Reynolds, J. Am. Chem. Soc., 70, 2402 (1948).
7. A. R. Surrey and H. F. Hammer, J. Am. Chem. Soc., 68,113 (1946).
8. M. G. Pratt and S. Archer, J. Am. Chem. Soc., 70, 4065 (1948).
9. G. U. Jadhav, Ind. J. Chem., 7, 669 (1930).
10. C. C. Price and R. M. Roberts, J. Am. Chem. Soc., 68,1204 (1946).
11. L. Velluz, G. Amiard, and M. Pesez, Bull. Soc. Chim. Fr., 678 (1948).
12. M. V. Rubtsov and V. I. Bunnia, J. Gen. Chem. USSR, 1, 1128 (1944).
13. A. R. Surrey and R. A. Cutler, J. Am. Chem. Soc., 73, 2623 (1951).
14. G. J. Atwell, B. F. Cain, and R. N. Seelye, J. Med. Chem., 11, 295 (1968).
15. R. I. Geran, N. H. Greenberg, M. M MacDonald, A. M. Schumacher, and B. J. Abbott, Cancer Chemother. Rep., Part 3, 3 (no. 2), 1 (1972).
16. J. L. Allison, R. L. O'Brien, and F. E. Hahn, Science, 149, 1111 (1965).
17. F. E. Hahn, R. L. O'Brien, J. Ciak, J. L. Allison, and J. G. Olenick, Mil. Med., Suppl., 131, 1071 (1966).
18. E. Marquez, J. W. Cranston, R. W. Ruddon, and J. H. Burckhalter, J. Med. Chem., 17, 856 (1974).
19. M. Suwalsky, W. Traub, U. Shmueli, and J. A. Subirana, J. Mol. Biol., 42, 363 (1969).
20. H. Tabor, C. W. Tabor, and S. M. Rosenthal, Annu. Rev. Biochem., 30, 579 (1961).
21. D. Kaiser, H. Tabor, and C. W. Tabor, J. Mol. Biol., 6,141 (1963).
22. R. Mozingo, “Organic Syntheses”, Collect. Vol. III, E. C. Horning, Ed., Wiley, New York, N.Y., 1955, p 181.
23. F. J. Bollum, Proc. Nucleic Acid Res., 1, 296 (1966).