Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 5, Issue 6, 1977, Pages 625-653

  Pang, K Sandy ^a   Rowland, Malcolm ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

blood flow; drug binding; hepatic drug clearance; hepatocelluSar enzymatic activity; intrinsic clearance; models

Indexed keywords

DEXTROPROPOXYPHENE; ENZYME; LIDOCAINE; PROPRANOLOL;

BIOAVAILABILITY; BLOOD CELL AGGREGATION; COMPARTMENT MODEL; DRUG BINDING; DRUG CLEARANCE; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; LIVER; LIVER BLOOD FLOW; MATHEMATICAL MODEL; MODEL; NONBIOLOGICAL MODEL; PHARMACOKINETICS; THEORETICAL STUDY;

BLOOD CELLS; HUMAN; LIVER; LIVER CIRCULATION; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017603437     PISSN: 0090466X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/BF01059688     Document Type: Article

References (38)

1. Studies of urea excretion
2. The gastric secretion of drugs: A pH partition hypothesis
3. Nonrespiratory function of the mammalian lung
4. Absorption kinetics of aspirin in man following oral administration of an aqueous solution
5. Blood levels of drug at the equilibrium state after multiple dosing
6. Influence of first pass effect on availability of drugs
7. The influence of route of administration on drug availability
8. Defective bromosulphthalein clearance in patients with constitutional hepatic dysfunction (Gilbert's syndrome)
9. Pharmacokinetics of drug dispostion: Hemodynamic considerations
10. Clearance concepts in pharmacokinetics
11. The disposition of propranolol. I. Elimination during oral absorption in man
12. Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs
13. Concentration of propoxyphene in human plasma following oral, intramuscular, and intravenous administration
14. Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey
15. Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation
16. Commentary: A physiological approach to hepatic drug clearance
17. Effect of protein binding on the elimination of warfarin
18. Clearance as a quantitative measure of liver function
19. The effect of hepatic perfusion on assessment of kinetic constants
20. Other aspects of pharmacokinetics
21. Hepatic vascular beds
22. Enzymatic elimination of substrates flowing through the intact liver
23. Capilliary-tissue exchange kinetics: Diffusional interactions between adjacent capillaries
24. Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig iiver
25. The disposition of propranolol. VIII. General implication of the effects of liver blood flow in elimination from the perfused rat liver
26. Effects of route of administration and blood flow on hepatic drug elimination
27. Clearance and biologic half-life as indices of intrinsic hepatic metabolism
28. Perfusion-limited effects of plasma drug binding on hepatic drug extraction
29. Pharmacokinetics in disease states modifying body perfusion
30. Dynamics of the circulation of the liver
31. The effect of upright position upon the hepatic blood flow
32. Interrelationships of hepatic blood flow, cardiac output and blood levels of lidocaine in man
33. Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liver in situ preparation
34. The effect of hepatic blood flow on the hepatic removal of oxyphenbutazone in the dog
35. Nonlinear tissue disposition: Salicylic acid in rat brain
36. Physicochemical properties, solubility, and protein binding of Δ9-tetrahydrocannabinol
37. Hepatic elimination kinetics: The influence of hepatic blood flow on clearance determinations