Synthesis and Structure-Activity Relations of Bestatin Analogs, Inhibitors of Aminopeptidase B

Journal of Medicinal Chemistry

Volumn 20, Issue 4, 1977, Pages 510-515

  Nishizawa, Rinzo ^a   Saino, Tetsushi ^a   Takita, Tomohisa ^b   Suda, Hiroyuki ^b   Aoyagi, Takaaki ^b   Umezawa, Hamao ^b  

^a NIPPON KAYAKU CO LTD   (Japan)

^b Institute of Microbial Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2 HYDROXYBUTYRYL) 4 PHENYL AMINOACID; 3 AMINO 2 HYDROXYPROPIONYLLEUCINE; AMINO ACID 3,5 DIMETHYLPYRAZOLIDE; AMINOPEPTIDASE B; BESTATIN; CYTOSOL AMINOPEPTIDASE; DRUG DERIVATIVE; LEUCINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ANALYSIS; DRUG COMPARISON; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; POLARIMETRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

AMINOPEPTIDASES; DIPEPTIDES; LEUCYL AMINOPEPTIDASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0017596420     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00214a010     Document Type: Article

References (5)

1. H. Umezawa, T. Aoyagi, H. Suda, M. Mamada, and T. Takeuchi, J. Antibiot., 29, 97 (1976).
2. H. Suda, T. Takita, T. Aoyagi, and H. Umezawa, J. Antibiot., 29, 100 (1976).
3. G. F. Bryce and B. R. Rabin, Biochem. J., 90, 509 (1964).
4. V. K. Hopsu-Havu, K. K. Mäkinen, and G. G. Glenner, Arch. Biochem. Biophys., 114, 557 (1966).
5. T. Nagasawa, K. Kuroiwa, K. Narita, and Y. Isowa, Bull. Chem. Soc. Jpn., 46, 1269 (1973).