Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

Chemico-Biological Interactions

Volumn 16, Issue 3, 1977, Pages 281-300

  Thakker, D R ^a   Yagi, H ^a   Akagi, H ^b   Koreeda, M ^b   Lu, A Y H ^c   Levin, W ^c   Wood, A W ^c   Conney, A H ^c   Jerina, D M ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; 4,5 DIHYDRO 4,5 DIHYDROXYBENZO[A]PYRENE C 14; 7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE H 3; 7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; 7,8,9,10 TETRAHYDRO 7BETA,8ALPHA DIHYDROXYBENZO[A]PYRENE 9ALPHA,10ALPHA OXIDE; 7,8,9,10 TETRAHYDRO 7BETA,8ALPHA DIHYDROXYBENZO[A]PYRENE 9BETA,10BETA OXIDE; 9,10 DIHYDRO 9,10 DIHYDROXYBENZO[A]PYRENE C 14; BENZ[A]ANTHRACENE C 14; BENZO[A]PYRENE 7,8 DIHYDRODIOL C 14; BENZO[A]PYRENE C 14; BENZO[A]PYRENE DERIVATIVE H 3; CYTOCHROME P448; DRUG METABOLITE; PHENOBARBITAL; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; DRUG ANALYSIS; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER; LIVER MICROSOME; MICROSOME; RAT; SPECTROPHOTOMETRY; STEREOSPECIFICITY; THEORETICAL STUDY;

ALCOHOLS; ANIMALS; BENZOPYRENES; CIRCULAR DICHROISM; CYTOCHROMES; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; ETHERS, CYCLIC; ISOMERISM; METHYLCHOLANTHRENE; MICROSOMES, LIVER; MOLECULAR CONFORMATION; MUTAGENS; RATS; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0017595986     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(77)90108-9     Document Type: Article

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