Severe toxicity and lethality in some monkeys following chronic administration of -αacetylmethadol (LAAM)

American Journal of Drug and Alcohol Abuse

Volumn 4, Issue 3, 1977, Pages 431-440

  Misra, A L ^a   Mule S J ^a  

^a New York State Office of Drug Abuse Services Testing and Research Laboratory ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLMETHADOL;

ANIMAL EXPERIMENT; AUTOPSY; DIMEPHEPTANOL ACETATE H 3; DRUG METABOLISM; DRUG TOXICITY; INTOXICATION; LETHALITY; LUNG EDEMA; MONKEY;

ANIMAL; FEMALE; HAPLORHINI; MACACA MULATTA; MALE; METHADONE; METHADYL ACETATE; NALORPHINE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017587088     PISSN: 00952990     EISSN: None     Source Type: Journal    
DOI: 10.3109/00952997709002776     Document Type: Article

References (24)

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2. Comparison of Acetylmethadol and Methadone in the Treatment of Long-term Heroin Users
3. Methadone and α-methady1 Aceta-tate. Use in Management of Narcotics Addicts
4. Methadyl Acetate vs. Methadone
5. Levomethadyl in Maintenance Treatment of Opiate Dependence
6. Current Status of the Evaluation of LAAM as a Maintenance Drug for Heroin Addicts
7. The Fate of the Optical Isomers of Alpha-acetylmethadol
8. The Metabolism of a-ctα-acetylmethadol in the Rat: The Identification of the Probable Active Metabolite
9. Metabolism of Acetylmethadol. A Sensitive Assay for Noracetylmethadol and the Identification of a New Active Metabolite
10. Metabolism of â-α-methadol. N-acetylation, a New Metabolic Pathway
11. α-acetylmethadol (LAM) Treatment of Opiate Dependence: Plasma and Urine Levels of Two Pharmacologically Active Metabolites
12. The Analgesic Activity of α-â-acetylmethadol and Two of its Metabolites in Mice
13. α-â-acetylmethadol and its N-demethylated Metabolites Have Potent Opiate Action in the Guinea Pig Isolated Ileum
14. The Binding of Optical Isomers of Methadone, a-methadol, â-acetylmethadol and their N-demethylated Derivative to the Opiate Receptors of Rat Brain
15. Simultaneous Determination of Acetylmethadol and its Active Biotransformation Products in Human Biofluids
16. Disposition of Acetylmethadol (LAAM) Pharmacokinetics and Metabolism: Current Status
17. Plasma levels of α-a-acetyl-Methadol (LAAM) and Metabolites Following Acute and Chronic Oral Administration in Man
18. Plasma α-â-acetylmethadol (LAAM) After Acute and Chronic Administration
19. Accumulation of α-a-acetylmethadol (LAAM) and Active Metabolites in Plasma Following Chronic Administration
20. Distribution of α-â-(2-3H)-Acetylmethadol (LAAM) and its Metabolites in Maternal and Fetal Rat Tissues
21. Estimation of α-â-2-3H] Acetylmethadol in Biological Materials and its Separation from Some Metabolites and Congeners on Glass Fibre Sheets
22. α-â-Acetylmethadol (LAAM) Pharmacokinetics and Metabolism: Current Status
23. 3H] acetylmethadol (LAAM) in the Monkey: Evidence for a New Metabolite
24. Disposition and Metabolism of α-a-[2-3H] Acetylmethadol (LAAM) in Acutely and Chronically-Treated Monkeys