Fecal Bile Acids and Cholesterol Metabolites of Patients with Ulcerative Colitis, a High-Risk Group for Development of Colon Cancer

Cancer Research

Volumn 37, Issue 6, 1977, Pages 1697-1701

  Reddy, Bandaru S ^a   Martin, Charles W ^a   Wynder, Ernst L ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTANOL; STEROL;

CARCINOGENESIS; COLON CARCINOMA; DIAGNOSIS; ETIOLOGY; FECES; MAJOR CLINICAL STUDY; ULCERATIVE COLITIS; ADULT; ARTICLE; COLON; COLON TUMOR; EPITHELIUM; EPITHELIUM CELL; FEMALE; HUMAN; INTESTINE POLYP; MALE; METABOLISM; RISK;

ADULT; BILE ACIDS AND SALTS; CHOLESTANOL; CHOLESTEROL; COLITIS, ULCERATIVE; COLON; COLONIC NEOPLASMS; EPITHELIAL CELLS; EPITHELIUM; FECES; FEMALE; HUMAN; INTESTINAL POLYPS; MALE; MIDDLE AGE; RISK; STEROLS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017368476     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Aries, V. C., Crowther, J. S., Drasar, B. S., Hill, M. J., and Williams, R. E. O. Bacteria and the Etiology of Cancer of the Large Bowel. Gut, 10: 334–335, 1969.
2. Burkitt, D. P. Some Diseases Characteristic of Modern Western Civilization. Clin. Radiol., 24: 271–280, 1973.
3. Farmer, R. G., Hawk, W. A., and Turnbull, R. B., Jr. Carcinoma Associated with Mucosal Ulcerative Colitis and with Transmural Colitis and Enteritis (Crohn's Disease). Cancer, 28: 289–292, 1971.
4. Finegold, C. M., and Lane, N. The Anatomical Precursor of Colorectal Carcinoma. Cancer, 34: 819–823, 1974.
5. Hill, M. J. The Effect of Some Factors on the Fecal Concentration of Acid Steroids, Neutral Steroids and Urolibins. J. Pathol., 104: 239-245, 1971.
6. Hill, M. J., Drasar, B. S., Aries, V. C., Crowther, J. S., Hawksworth, G. M., and Williams, R. E. O. Bacteria and the Etiology of Cancer of the Large Bowel. Lancet, 1: 95–100, 1971.
7. Hill, M. J., Drasar, B. S., Williams, R. E. O., Meade, T. W., Cox, A. G., Simpson, J. E. P., and Morson, B. C. Fecal Bile Acids and Clostridia in Patients with Cancer of the Large Bowel. Lancet, 2: 535–539, 1975.
8. Lipkin, M. Phase 1 and Phase 2 Proliferative Lesions of Colonic Epithelial Cells in Diseases Leading to Colonic Cancer. Cancer, 34: 878–888, 1974.
9. MacDougall, I. P. M. The Cancer Risk in Ulcerative Colitis. Lancet, 2: 655–658, 1964.
10. Miettinen, T. A. The Role of Bile Salts in Diarrhea of Patients with Ulcerative Colitis. Gut, 12: 632–635, 1971.
11. Miettinen, T. A. Clinical Implications of Bile Acid Metabolism in Man. In: P. P. Nair and D. Kritchevsky (eds.), The Bile Acids, Vol. 2. Physiology and Metabolism, pp. 191–247. New York: Plenum Press, 1973.
12. Morson, B. C. Evolution of Cancer of the Colon and Rectum. Cancer, 34: 845–849, 1974.
13. Narisawa, T., Magadia, N. E., Weisburger, J. H., and Wynder, E. L. Promoting Effect of Bile Acids on Colon Carcinogenesis after Intrarectal Instillation of N-methyl-N'-nitro-N-nitrosoguanidine in Rats. J. Natl. Cancer Inst., 55: 1093–1097, 1974.
14. Reddy, B. S., Mastromarino, A., Gustafson, C., Lipkin, M., and Wynder, E. L. Fecal Bile Acids and Neutral Sterols in Patients with Familial Polyposis. Cancer, 38: 1694–1698, 1976.
15. Reddy, B. S., Narisawa, T., and Weisburger, J. H. Promoting Effect of Sodium Deoxycholate on Adenocarcinomas in Germfree Rats. J. Natl. Cancer Inst., 56: 441–442, 1976.
16. Reddy, B. S., Weisburger, J. H., and Wynder, E. L. Effects of High Risk and Low Risk Diets for Colon Carcinogenesis on Fecal Microflora and Steroids in Man. J. Nutr., 105: 878–884, 1975.
17. Reddy, B. S., and Wynder, E. L. Large Bowel Carcinogenesis: Fecal Constituents of Populations with Diverse Incidence Rates of Colon Cancer. J. Natl. Cancer Inst., 50: 1437–1442, 1973.
18. Reddy, B. S., and Wynder, E. L. Metabolic Epidemiology of Colon Cancer: Fecal Bile Acids and Neutral Sterols in Colon Cancer Patients and Patients with Adenomatous Polyps. Cancer, in press.
19. Rios-Dalenz, J., Smith, L. B., and Thompson, T. F. Diseases of the Colon and Rectum in Bolivia. Am. J. Surg., 129: 651–654, 1975.
20. Wattenberg, L. W. Effects of Dietary Constituents on the Metabolism of Chemical Carcinogens. Cancer Res., 35: 3326–3331, 1975.
21. Wenstrom, J., Pierce, E. R., and McKusick, V. A. Hereditary Benign and Malignant Lesions of the Large Bowel. Cancer, 34: 850-857, 1974.
22. Wilk, M., and Taupp, W. Dehydrierung des Cholesterins in Aktiviert Adsorbierten Zustand unter Normalbedingungen, ein Beitrag zur Frage der Endogenese carcinogener, polycyclischer Kohlenwasserstoffe. Z. Naturforsch., 24B: 16–23, 1969.
23. Wynder, E. L., Kajitani, T., Ishikawa, S., Dodo, H., and Takano, A. Environmental Factors of Cancer of the Colon and Rectum. II. Japanese Epidemiological Data. Cancer, 23: 1210–1220, 1969.
24. Yardley, J. H., and Keren, D. F. Precancer Lesions in Ulcerative Colitis. A Retrospective Study of Rectal Biopsy and Colectomy Specimens. Cancer, 34: 835–844, 1974.