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Volumn 32, Issue 2, 1976, Pages 140-142

Roquefortine and isofumigaclavine A, metabolites from Penicillium roqueforti

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE;

EID: 0017291101     PISSN: 00144754     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/BF01937728     Document Type: Article
Times cited : (144)

References (14)
  • 1
    • 84931241635 scopus 로고    scopus 로고
    • Acknowledgements. We thank S. Moreau for mycelium of P. roqueforti and J.-C. Gripon and Mlle E. Zissmann for additional cultures; B. Septe for13C nmr-spectra: S. K. Kan for the 240 MHz1H nmr-spectrum of roquefortine; Mme Le Phan Diêp for amino acid analyses; and S. Wilkinson and P. G. Mantle, respectively, for samples of fumigaclavine B and agroclavine.
  • 3
    • 84931241634 scopus 로고    scopus 로고
    • By high resolution mass spectroscopy, courtesy of P. Varenne, W. B. Turner and W. F. Miles. We thank B. C. Das for helpful discussion.
  • 6
    • 84931241637 scopus 로고    scopus 로고
    • S. Sape and A. Taylor, J. chem. Soc. Perkin I 1972, 472.
  • 7
    • 84931241636 scopus 로고    scopus 로고
    • D. W. Nagel, K. G. R. Pachler, P. S. Steyn, P. L. Wessels, G. Gafner and G. J. Kruger, J. chem. Soc., Chem. Commun. 1974, 1021.
  • 8
    • 84931241639 scopus 로고    scopus 로고
    • P. S. Steyn, personal communication.
  • 9
    • 84931241638 scopus 로고    scopus 로고
    • W. D. Jamieson, R. Rahman and A. Taylor, J. chem. Soc. (C) 1969, 1564.
  • 10
    • 84931241652 scopus 로고    scopus 로고
    • H. Minato, M. Matsumoto and T. Katayama, J. chem. Soc. Perkin I 1973, 1819.
  • 13
    • 84931241651 scopus 로고    scopus 로고
    • Experiments carried out at the Institut de Recherches Scientifiques sur le Cancer, Villejuif, France by C. Frayssinet and Christiane Frayssinet showed that the LD50 (i.p., male mice) was 15–20 mg/kg. Doses of 50–100 mg/kg caused prostration and an atonic posture. The prostration would be interrupted for a few seconds by opisthotonoid seizures which could be brought about by noise or a tap on the cage. Death followed within a few hours. At doses of 10 mg/kg convulsions were replaced by simple contractions and the state of prostration by equilibrium disorders during movement.


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