Vitamin A Transport in Human Vitamin A Toxicity

New England Journal of Medicine

Volumn 294, Issue 15, 1976, Pages 805-808

  Smith, Frank Rees ^a   Goodman, Dewitt S ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOL; VITAMIN;

BONE PAIN; BRAIN PSEUDOTUMOR; CLINICAL STUDY; DERMATITIS; DRUG ABSORPTION; DRUG METABOLISM; DRUG PROTEIN BINDING; HEPATITIS; HYPERVITAMINOSIS; INTOXICATION; MAJOR CLINICAL STUDY; PLASMA; PROTEIN BINDING;

EID: 0017251079     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM197604082941503     Document Type: Article

References (28)

1. Josephs H.W.: Hypervitaminosis A and carotenemia. Am J Dis Child 67: 33–43, 1944
2. Morrice G Jr., Havener W.H., Kapetansky F: Vitamin A intoxication as a cause of pseudotumor cerebri. JAMA 173: 1802–1805, 1960
3. Rubin E, Florman A.L., Degnan T, et al: Hepatic injury in chronic hypervitaminosis A. Am J Dis Child 119: 132–138, 1970
4. Muenter M.D., Perry H.O., Ludwig J: Chronic vitamin A intoxication in adults: hepatic, neurologic and dermatologic complications. Am J Med 50: 129–136, 1971
5. Russell R.M., Boyer J.L., Bagheri S.A., et al: Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites. N Engl J Med 291: 435–440, 1974
6. Frame B, Jackson C.E., Reynolds W.A., et al: Hypercalcemia and skeletal effects in chronic hypervitaminosis A. Ann Intern Med 80: 44–48, 1974
7. Kanai M, Raz A, Goodman DeWS: Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest 47: 2025–2044, 1968
8. Peterson P.A., Berggård I: Isolation and properties of a human retinol-transporting protein. J Biol Chem 246: 25–33, 1971
9. Dingle J.T., Fell H.B., Goodman DeWS: The effect of retinol and of retinol-binding protein on embryonic skeletal tissue in organ culture. J Cell Sci 11: 393–402, 1972
10. Mallia A.K., Smith J.E., Goodman DeWS: Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat. J Lipid Res 16: 180–188, 1975
11. Thompson J.N., Erdody P, Brien R, et al: Fluorometric determination of vitamin A in human blood and liver. Biochem Med 5: 67–89, 1971
12. Smith F.R., Raz A, Goodman DeWS: Radioimmunoassay of human plasma retinol-binding protein. J Clin Invest 49: 1754–1761, 1970
13. Smith F.R., Goodman DeWS: The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J Clin Invest 50: 2426–2436, 1971
14. Goodman DeWS, Blomstrand R, Werner B, et al: The intestinal absorption and metabolism of vitamin A and β-carotene in man. J Clin Invest 45: 1615–1623, 1966
15. Goodman DeWS, Huang H.S., Shiratori T: Tissue distribution and metabolism of newly absorbed vitamin A in the rat. J Lipid Res 6: 390–396, 1965
16. Fidge N.H., Shiratori T, Ganguly J, et al: Pathways of absorption of retinal and retinoic acid in the rat. J Lipid Res 9: 103–109, 1968
17. Raz A, Shiratori T, Goodman DeWS: Studies on the protein-protein and protein-ligand interactions involved in retinol transport in plasma. J Biol Chem 245: 1903–1912, 1970
18. Moore T: Vitamin A. New York, Elsevier Press Incorporated, 1957
19. Goodman DeWS: Vitamin A transport and retinol-binding protein metabolism. Vitam Horm 32: 167–180, 1974
20. Arroyave G, Wilson D, Méndez J, et al: Serum and liver vitamin A and lipids in children with severe protein malnutrition. Am J Clin Nutr 9: 180–185, 1961
21. Smith F.R., Goodman DeWS, Zaklama M.S., et al: Serum vitamin A, retinol-binding protein, and prealbumin concentrations in protein-calorie malnutrition. I. A functional defect in hepatic retinol release. Am J Clin Nutr 26: 973–981, 1973
22. Smith F.R., Underwood B.A., Denning C.A., et al: Depressed plasma retinol-binding protein levels in cystic fibrosis. J Lab Clin Med 80: 423–433, 1972
23. Smith F.R., Lindenbaum J: Human serum retinol transport in malabsorption. Am J Clin Nutr 27: 700–705, 1974
24. Dingle J.T.: Vacuoles, vesicles and lysosomes. Br Med Bull 24: 141–145, 1968
25. Roels O.A., Anderson O.R., Lui N.S.T., et al: Vitamin A and membranes. J Clin Nutr 22: 1020–1032, 1969
26. Bangham A.D., Dingle J.T., Lucy J.A.: Studies on the mode of action of excess of vitamin A. I.X. Penetration of lipid monolayers by compounds in the vitamin A series. Biochem J 90: 133–140, 1964
27. Fell H.B., Dingle J.T.: Studies on the mode of action of excess of vitamin A V.I. Lysosomal protease and the degradation of cartilage matrix. Biochem J 87: 403–408, 1963
28. Dingle J.T., Barrett A.J., Weston P.D.: Cathepsin D: characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J 123: 1–13, 1971