Epidermal cell proliferation and promoting ability of phorbol esters

Journal of the National Cancer Institute

Volumn 57, Issue 5, 1976, Pages 1145-1149

  Scribner, John D ^b   Thompson, Sara ^b  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; PHORBOL; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIACETATE; PHORBOL DIBENZOATE; PHORBOL DIDECANOATE; PHORBOL ESTER;

CELL PROLIFERATION; DOSE RESPONSE; DRUG COMPARISON; DRUG RESPONSE; EDEMA; EPIDERMIS HYPERPLASIA; HISTOLOGY; INFLAMMATION; MOUSE; PHORBOL 12,13 DIOCTANOATE; SKIN CARCINOGENESIS; SKIN TUMOR; THEORETICAL STUDY; TOPICAL DRUG ADMINISTRATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMAL; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EDEMA; FEMALE; HYPERPLASIA; INFLAMMATION; MICE; NEOPLASMS, EXPERIMENTAL; PAPILLOMA; PHORBOL ESTERS; PHORBOLS; SKIN; SKIN NEOPLASMS; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE;

EID: 0017175792     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/57.5.1145     Document Type: Article

References (28)

1. Berenblum I, Shubik P: A new, quantitative approach to the study of the stages of chemical carcinogenesis in the mouse’s skin. Br J Cancer 1:383-391, 1947
2. Boutwell RK: Some biological aspects of skin carcinogenesis. Prog Exp Tumor Res 4:207-250, 1964
3. Bresch H, Kreibich G, Kubinyi H, et al: Über die Wirkstoffe des Crotonöls. IX. Partialsynthese von Wirkstoffen des Croton- öls. Z Naturforsch [C] 23b: 538-546, 1968
4. Hecker E, von Szczepanski C, Kubinyi H, et al: Über die Wirkstoffe des Crotonöls. VII. Phorbol. Z Naturforsch [C] 21b:1204-1214, 1966
5. Gilbert JP, Sice J: Dose-response relationship of a tumor-promoting agent. Toxicol Appl Pharmacol 2:392-396, 1960
6. Van Duuren BL, Sivak A, Segal A, et al: Dose-response studies with a pure tumor-promoting agent, phorbol myristate acetate. Cancer Res 33:2166-2172, 1973
7. Slaga TJ, Bowden GT, Scribner JD, et al: Dose-response studies on the ability of 7, 12-dimethylbenz[a]anthracene and benz- [a]anthracene to initiate skin tumors. J Natl Cancer Inst 53:1337-1340, 1974
8. Baird WM, Boutwell RK: Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin. Cancer Res 31:1074-1079, 1971
9. Raick AN: Ultrastructural, histological, and biochemical alterations produced by 12-0-tetradecanoyl-13-acetate on mouse epi-dermis and their relevance to skin tumor promotion. Cancer Res 33:269-286, 1973
10. Scribner JD, Boutwell RK: Inflammation and tumor promotion: Selective protein induction in mouse skin by tumor promoters. Eur J Cancer 8:617-621, 1972
11. Gwynn RH, Salamon NH: Studies on co-carcinogenesis, SH-reactors and other substances tested for co-carcinogenic action in mouse skin. Br J Cancer 7:482-489, 1953
12. Belman S, Troll W: The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones. Cancer Res 32:450-454, 1972
13. Scribner JD, Slaga TJ: Multiple effects of dexamethasone on protein synthesis and hyperplasia caused by a tumor promoter. Cancer Res 33:542-546, 1973
14. Slaga TJ, Scribner JD: Inhibition of tumor initiation and promotion by anti-inflammatory agents. J Natl Cancer Inst 51:1723-1725, 1973
15. Slaga TJ, Bowden GT, Boutwell RK: Acetic acid, a potent stimulator of mouse epidermal macromolecular synthesis and hyperplasia but with weak tumor-promoting ability. J Natl Cancer Inst 55:983-987, 1975
16. Raick AN, Burdzy K: Ultrastructural and biochemical changes induced in mouse epidermis by a hyperplastic agent, ethylphenylpropiolate. Cancer Res 33:2221-2230, 1973
17. Raick AN: Cell proliferation and promoting action in skin carcinogenesis. Cancer Res 34:920-926, 1974
18. Hennings H, Boutwell RK: Studies on the mechanism of skin tumor promotion. Cancer Res 30:312-320, 1970
19. Baird WM, Sedgwick JA, Boutwell RK: Effects of phorbol and four diesters of phorbol on the incorporation of tritiated precursors into DNA, RNA and protein in mouse epidermis. Cancer Res 31:1434-1439, 1971
20. Berenblum I: A speculative review: The probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis. Cancer Res 14:471-477, 1954
21. Frei JV, Stephens P: The correlation of promotion of tumour growth and induction of hyperplasia in epidermal two-stage carcinogenesis. Br J Cancer 22:83-92, 1968
22. 3H into mouse skin RNA at early times after treatment with phorbol esters. Cancer Res 32:781-788, 1972
23. Raick AN, Thumm K, Chivers BR: Early effects of 12-O-tetra- decanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion in mouse skin. Cancer Res 32:1562-1568, 1972
24. Van Duuren BL: Tumor-promoting agents in two-stage carcino genesis. Prog Exp Tumor Res 11:31-68, 1969
25. Raick AN: Cell differentiation and tumor-promoting action in skin carcinogenesis. Cancer Res 34:2915-2925, 1974
26. Slaga TJ, Scribner JD, Rice JM, et al: Inhibition by dexameth asone of intracellular binding of phorol esters to mouse skin. J Natl Cancer Inst 52:1611-1618, 1974
27. Scribner JD, Slaga TJ: Influence of nonsteroid anti-inflammatory agents on protein synthesis and hyperplasia caused by a tumor promoter. J Natl Cancer Inst 52:1865-1868, 1974
28. O’Brien TG, Simsiman RC, Boutwell RK: Induction of the polyamine-biosynthetic enzymes in mouse epidermis and their specificity for tumor promotion. Cancer Res 35:2426-2433, 1975