Clinical pharmacokinetics of lorazepam I. Absorption and disposition of oral 14C-lorazepam

Clinical Pharmacology and Therapeutics

Volumn 20, Issue 3, 1976, Pages 329-341

  Greenblatt, David J ^a,b,c   Schillings, Roger T ^a,b,c   Kyriakopoulos, Adrian A ^a,b,c   Shader, Richard I ^a,b,c   Sisenwine, Samuel F ^a,b,c   Knowles, John A ^a,b,c   Ruelius, Hans W ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; DRUG METABOLITE; GLUCURONIDE; HYDROXYLORAZEPAM; LORAZEPAM; QUINAZOLINE ACID; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG; LORAZEPAM C 14; RADIOISOTOPE;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; BODY FLUID; CLINICAL ASSESSMENT; CONCENTRATION RESPONSE; DIPLOPIA; DIZZINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISPOSITION; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ELIMINATION HALF-LIFE; FECES ANALYSIS; HEADACHE; HUMAN; HUMAN EXPERIMENT; HYPERHIDROSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MIDDLE AGED; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOACTIVITY; RENAL CLEARANCE; URINALYSIS; URINARY EXCRETION; VENOUS BLOOD; XEROSTOMIA; BIOTRANSFORMATION; DRUG ANALYSIS; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; FECES; GAS LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PLASMA; THEORETICAL STUDY; THIN LAYER CHROMATOGRAPHY; URINE;

ADMINISTRATION, ORAL; ADULT; ANTI-ANXIETY AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, THIN LAYER; GLUCURONATES; HALF-LIFE; HUMANS; KINETICS; LORAZEPAM; MALE; MIDDLE AGED;

EID: 0017088662     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt1976203329     Document Type: Article

References (42)