The hormonal and metabolic basis of experimental obesity

Clinics in Endocrinology and Metabolism

Volumn 5, Issue 2, 1976, Pages 337-365

  Assimacopoulos Jeannet, Françoise ^a   Jeanrenaud, Bernard ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN RECEPTOR;

ADIPOCYTE; ADIPOSE TISSUE; BODY WEIGHT; CELL MEMBRANE; DIABETES MELLITUS; DRUG SENSITIVITY; FOOD INTAKE; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPHAGIA; HYPOGLYCEMIA; HYPOTHALAMUS; INSULIN RELEASE; INSULIN RESISTANCE; LIPOGENESIS; LIVER; MUSCLE; OBESITY; PANCREAS ISLET BETA CELL; REVIEW;

ADIPOSE TISSUE; ANIMAL; BODY WEIGHT; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; EATING; GLUCOSE; HYPERGLYCEMIA; HYPERINSULINISM; HYPOTHALAMUS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; LIPIDS; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, INBRED C57BL; MICE, OBESE; MUSCLES; OBESITY; PROTEIN BINDING; RATS; RATS, INBRED STRAINS; RECEPTORS, CELL SURFACE;

EID: 0017074780     PISSN: 0300595X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-595X(76)80025-4     Document Type: Article

References (170)

1. Hormonal control of intermediary metabolism in obese hyperglycemic mice. I. The sensitivity and response to insulin in adipose tissue and muscle in vitro
2. Hormonal control of intermediary metabolism in obese hyperglycemic mice. II. Levels of plasma free fatty acid and immunoreactive insulin and liver glycogen
3. Enzyme activities in muscle and liver after destruction of the ventromedial hypothalamic area and administration of insulin
4. Overeating and obesity from damage to a noradrenergic system in the brain
5. Hypothalamic hyperphagia: dissociation from hyperphagia following destruction of noradrenergic neurons
6. Nervous regulation of food intake
7. Activity of single neurons in the hypothalamic feeding centers: effect of glucose
8. Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man
9. Abnormalities in lipogenesis and triglyceride secretion by perfused livers of obesehyperglycaemic (ob/ob) mice: relationship with hyperinsulinaemia
10. Ventromedial hypothalamus and hyperphagia in hyperglycemic obese mice
11. Feeding patterns of normal and ventromedial hypothalamic lesioned male and female rats
12. Neuroendocrine conditioning: Conditioned feeding after alterations in glucose utilization
13. Hypothalamic sensitivity to 2-deoxy-D-glucose and glucose: effects on feeding behavior
14. The hypothalamus, especially on its fiber connections, and the septo-preopticohypothalamic system
15. The septo-preoptico-hypothalamic system and its autonomic function
16. Plasma triglycerides in genetically obese rats
17. The response of the reproductive system in the female mutant mouse, obese (genotype obob) to gonadotrophin-releasing hormones
18. The control of insulin receptors in the New Zealand obese mouse
19. Inhibitory controls of feeding by the ventromedial hypothalamus
20. In vitro studies on insulin secretion in the genetically obese mouse
21. Influence of the mutation “diabetes” on insulin release and islet morphology in mice of different genetic backgrounds
22. Genetically transmitted obesity in rodents
23. Studies on food intake of genetically obese rats
24. Lipogenesis in adipose tissue from genetically obese rats
25. Genetic obesity in rats. I. The effects of food restriction on body composition and hypothalamic function
26. Reversal by 2-bromostearate of the impairment of glucose and pyruvate oxidation in diaphragm of fat-fed rats, in vitro
27. Studies on the metabolic effects induced in the rat by a high-fat diet. Inhibition of pyruvate metabolism in diaphragm in vitro and its relation to the oxidation of fatty acids
28. Effects of glucose on multi-unit activity in the hypothalamus
29. Genetic control of metabolism: enzyme studies of the obese and adipose mutants in the mouse
30. Biochemical and morphological studies of immunoreactive insulin secretion in spontaneous and acquired obesity and/or hyperglycemia in rodents
31. Kinetics of immunoreactive insulin release in obese hyperglycemic laboratory rodents
32. Nervous regulation of glucose homeostasis
33. Insulin resistance of parabiotic obese-hyperglycemic mice (obob)
34. Obesity and insulin resistance in the obese-hyperglycemic mouse (obob)
35. Glucose tolerance and time sequence of adiposity, hyperinsulinemia and hyperglycemia in obese-hyperglycemic mice (obob)
36. Metabolism in vitro of adipose tissue in obese-hyperglycaemic and goldthioglucose-treated mice I Metabolism of glucose
37. Metabolism in vitro of adipose tissue in obese-hyperglycaemic and goldthioglucose-treated mice II Metabolism of pyruvate and acetate
38. Effects of parabiosis of obese with diabetes and normal mice
39. Effects of parabiosis of normal with genetically diabetic mice
40. The effects of hypothalamic lesions in genetically diabetic mice
41. The influence of genetic background on the expression of the obese (Ob) gene in the mouse
42. Hyperinsulinemia in pre-weaning diabetes (db) mice
43. Genetic versus hypothalamic obesity: Studies of intake and dietary manipulations in rats
44. Insulin—receptor interactions in adipose tissue cells: Direct measurement and properties
45. Lipolysis and triglyceride turnover in rat adipose cells: effects of cell size
46. Enhancement of feeding produced by stimulation of the ventromedial hypothalamus
47. Rapid effects of insulin on the hypothalamic satiety center
48. Diabetes-induced resistance of ventromedial hypothalamus to damage by gold thioglucose: reversal by adrenalectomy
49. Lipoprotein lipase activities in adipose tissues, heart and diaphragm of the genetically obese mouse (ob/ob)
50. Adipose-tissue lipoprotein lipase activity and cellularity in the genetically obese Zucker rat (fa/fa)
51. The rat forebrain in stereotaxic coordinates
52. Ethological and neurological aspects of the regulation of food intake
53. Hepatic metabolism in normal and genetically obese mice
54. Fatty acid mobilization in obese mice
55. Clearing-factor lipase in obese hyperglycaemic mice (ob/ob)
56. A combined biochemical and histological study on the islets of Langerhans in the genetically obese hyperglycaemic mouse and in the lean mouse, including observations on the effects of streptozotocin treatment
57. Role of the increased-adipose tissue mass in the apparent insulin insensitivity of obesity
58. Insulin receptors in the heart muscle. Demonstration of specific binding sites and impairment of insulin binding in the plasma membrane of the obese hyperglycemic mouse
59. Ventromedial syndrome: the rats “finickiness” results from the obesity, not from the lesions
60. Interactions of polypeptide hormones with cell membrane specific receptors studies with insulin and glucagon
61. Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse
62. Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels
63. Studies of insulin sensitivity in vivo in weanling rats with hypothalamic obesity
64. 14C-glucose in weanling rats with hypothalamic obesity
65. Plasma insulin and triglyceride levels after hypothalamic lesions in weanling rats
66. Central and sensory control of food intake in genetically obese mice
67. Further studies on the amelioration of the characteristics of New Zealand obese (NZO) mice following implantation of islets of Langerhans
68. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture
69. Hyperinsulinism in mice with genetically determined obesity
70. Insulin resistance in genetically obese, hyperglycemic mice
71. Hypothalamic obesity: the myth of the ventromedial nucleus
72. Metabolism of glucose, fructose and pyruvate in tissues of weanling rats with hypothalamic obesity
73. Persistent adipose tissue insulin responsiveness during fasting of weanling rats with hypothalamic obesity
74. Insulin responsiveness in vitro of diaphragm and adipose tissue from weanling rats with hypothalamic obesity
75. Food intake in hypothalamic obesity
76. In vivo and in vitro metabolism in hypothalamic obesity
77. Postnatal development of adipocyte cellularity in the normal rat
78. Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice
79. Function of the pancreatic B-cell during the development of hyperglycaemia in mice homozygous for the mutations “diabetes” (db) and “Misty” (m)
80. Insulin sensitivity of pair-fed, hyperlipemic, hyperinsulinemic, obese-hypothalamic rats
81. Enlarged pancreatic islets of tube-fed hypophysectomized rats bearing hypothalamic lesions
82. Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese-hyperglycemic mice
83. The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains
84. Correlation between hyperinsulinemia and hyperphagia in rats with ventromedial hypothalamic lesions
85. Rapid effect of ventromedial hypothalamic lesions on lipogenesis in rats
86. Stimulation of insulin release by a ventrolateral hypothalamic factor
87. Metabolic anomalies of the obese-hyperglycemic (ob/ob) mice of Bar Harbor
88. Cellularity of adipose depots in six strains of genetically obese mice
89. Effect of early nutrition and adipose cellularity and pancreatic insulin release in the Zucker rat
90. Cellularity of adipose depots in the genetically obese Zucker rat
91. Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob/ob)
92. Insulin-receptor interaction in the obese-hyperglycemic mouse A model of insulin resistance
93. Insulin receptor defect in insulin resistance: Studies in the obese-hyperglycemic mouse
94. Adaptive enzyme responses in adipose tissue of obese hyperglycemic mice
95. Kinetic and electrophoretic abnormality of cyclic AMP phosphodiesterase in genetically obese mouse adipocytes
96. An anomaly of insulin removal in perfused livers of obese-hyperglycemic (ob/ob) mice a possible factor contributing to hyperinsulinemia
97. Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism
98. Regulation of glycerol kinase by insulin in isolated fat cells and liver of Bar Harbor obese mice
99. Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice
100. Ventromedial hypothalamic hyperphagia in the hypophysectomized weanling rat
101. An impaired response of adenylate cyclase to stimulation by epinephrine in adipocyte plasma membranes from genetically obese mice (ob/ob)
102. Reciprocal hunger-regulatory circuits involving alpha and betaadrenergic receptors located respectively in ventromedial and lateral hypothalamus
103. Relation of insulin receptors to insulin resistance
104. The autoregulation of insulin secretion in the isolated pancreatic islets of lean (obOb) and obese-hyperglycemic (obob) mice
105. In vivo studies on lipogenesis in obese hyperglycaemic (ob/ob) mice: possible role of hyperinsulinemia
106. Does hyperinsulinaemia in ob/ob mice cause an insulin-stimulated adipose tissue?
107. Correlation between altered acetate utilization and hyperphagia in rats with ventromedial hypothalamic lesions
108. Increased hepatic triacylglycerol secretion in fasted rats with ventromedial hypothalamic lesions
109. Amelioration of insulin resistance in obese mice
110. Adaptive response of hepatic acetylCoA carboxylase to dietary alterations in genetically obese mice and their lean controls
111. In vivo lipogenesis and enzyme levels in adipose and liver tissues from pairfed genetically obese and lean rats
112. Insulin and growth hormone secretion in rats with ventromedial hypothalamic lesions maintained on restricted food intake
113. Hypothalamic stimulation of insulin release
114. Changes in liver and adipose tissue enzymes and lipogenic activities during the onset of hypothalamic obesity in mice
115. Early development of adipose cell lipogenesis and glycerol utilization in Zucker obese rats
116. Adipose and liver tissue enzyme profiles in obese hyperglycemic mice
117. Induction of diabetic alterations by goldthioglucose-obesity in KK, ICR and C57BL mice
118. Glucostatic mechanisms of regulation of food intake
119. Determinants of food intake in obesity
120. Hunger, obesity, and the ventromedial hypothalamus
121. Glucose and osmosensitive neurones of the rat hypothalamus
122. Obesity and increased growth following partial or complete isolation of ventromedial hypothalamus
123. 14C in rats
124. Neural regulation of insulin secretion in the dog
125. Ventromedial hypothalamic obesity abolished by subdiaphragmatic vagotomy
126. Ventromedial hypothalamic control of food intake and satiety: A reappraisal
127. Regulation of glucose uptake by muscle. Effect of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles
128. Lipoprotein lipase activities in tissues of normal and genetically obese (ob/ob) mice
129. Role of free fatty acids in glucose homeostasis
130. Reproductive function in the genetically obese “fatty” rat
131. The effect of insulin upon glucose metabolism by adipose cells of different size. Influence of cell lipid and protein content, age, and nutrition state
132. Glucose metabolism and the response to insulin by human adipose in spontaneous and experimental obesity. Effects of dietary composition and adipose cell size
133. Plasma lipoproteins and the synthesis and turnover of plasma triglyceride in normal and genetically obese mice
134. The efferent connections of the ventromedial nucleus of the hypothalamus
135. Hypertriglyceridemia in weanling rats with hypothalamic obesity
136. Overproduction of very low-density lipoproteins by livers of genetically obese rats
137. Multiple knife cuts between the medial and lateral hypothalamus in the rat: a reevaluation of hypothalamic feeding circuitry
138. Contemporary topics in the study of diabetes and metabolic endocrinology II
139. Lipolysis in the adipose tissue of mice made obese with goldthioglucose
140. Effects of hypothalamic stimulations on gluconeogenesis and glycolysis in rat liver
141. Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content
142. Structural changes of pancreatic islets in genetically obese rats
143. Sequential changes in glucose metabolism by adipose tissue and liver of rats after destruction of the ventromedial hypothalamic nuclei: effect of three dietary regimens
144. Hypothalamic glucoreceptors — the influence of gold thioglucose implants in the ventromedial and lateral hypothalamic areas of normal and diabetic rats
145. Thymic lymphocytes in obese (ob/ob) mice. A mirror of the insulin receptor defect in liver and fat
146. Insulin receptor deficiency in genetic and acquired obesity
147. Effect of insulin in vivo on diaphragm and adipose tissue of obese mice
148. Metabolisme du glucose dans le tissu adipeux et le muscle des animaux présentant une obésité métabolique ou une obésité par hyperphagie
149. Spontaneous hyperglycemia and/or obesity in laboratory rodents: an example of the possible usefulness of animal disease models with both genetic and environmental components
150. The metabolism of ketones, triglyceride and monoglyceride in livers of obese hyperglycaemic mice
151. An analysis of the lipolysis in vitro of obesehyperglycaemic and diabetic mice
152. Pancreatic insulin release and peripheral tissue resistance in Zucker obese rats fed high- and low-carbohydrate diets
153. Insulin resistance and pancreatic insulin release in the genetically obese Zucker rat
154. Studies of hereditary-obese mice (obob) after implantation of pancreatic islets in millipore filter capsules
155. Evidence for an insulin-sensitive receptor in the central nervous system
156. Metabolic and endocrine aspects of the ventromedial hypothalamic syndrome in the rat
157. Development of the obese-hyperglycaemic syndrome in mice
158. Pathogenetic aspects of the obese-hyperglycemic syndrome in mice (genotype obob): I. Function of the pancreatic B-cells
159. Neural control of the endocrine pancreas
160. Dependence of hypothalamic obesity on insulin, the pituitary and the adrenal gland
161. Genetic obesity in rats. II. The effect of food restriction on the metabolism of adipose tissue
162. Hyperinsulinemia and insulin resistance in genetically obese rats
163. Thyrotropin secretion in genetically obese rats
164. Metabolism in experimental obesity induced in the rat by varying levels of dietary fat
165. Fat mobilization in vitro and in vivo in the genetically obese Zucker rat “fatty”
166. Insulin and obesity in the Zucker genetically obese rat “fatty”
167. Fat accretion and growth in the rat