DNA-binding characteristics of acridinylmethanesulphonanilide drugs: Comparison with antitumour properties

European Journal of Cancer (1965)

Volumn 12, Issue 12, 1976, Pages 995-1001

  Waring, M J ^a,b  

^a Cancer Research Laboratory   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACRIDINE DERIVATIVE; AMSACRINE; DNA; DRUG; ETHIDIUM BROMIDE; SN 11838; SN 12735; UNCLASSIFIED DRUG;

CANCER CHEMOTHERAPY; DRUG COMPARISON; DRUG SCREENING; DRUG SYNTHESIS; LEUKEMIA; LEUKEMIA L 1210; METHODOLOGY; MOUSE; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

ANILIDES; ANIMAL; BINDING SITES; COMPARATIVE STUDY; DNA, CIRCULAR; LEUKEMIA L1210; STRUCTURE-ACTIVITY RELATIONSHIP; VISCOSITY;

EID: 0017040487     PISSN: 00142964     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2964(76)90066-9     Document Type: Article

References (25)

1. Potential antitumour agents. 14. Acridylmethanesulphonanilides
2. Potential antitumour agents. 16. 4′(Acridin-9-ylamino) methanesulphonanilides
3. Potential antitumour agents. 17. 9-anilino-10-methylacridinium salts
4. Potential antitumour agents. 19. Multiply substituted 4′-(9-acridinylamino)-methanesulphonanilides
5. The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series
6. Inhibitors of nucleic acid synthesis
7. Potential antitumour agents. 11. 9-anilinoacridines
8. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation
9. Interaction of indazole analogues of lucanthone and hycanthone with closed circular duplex DNA
10. The unwinding of circular DNA by phenanthridinium drugs: structure-activity relations for the intercalation reaction
11. Stereochemical aspects of the interaction between steroidal diamines and DNA
12. Structural constraints in the binding of drugs to DNA
13. DNA of bacteriophage PM2: a closed circular double-stranded molecule
14. Direct determination of the superhelix density of closed circular DNA by viscometric titration
15. Viscosity and sedimentation study of sonicated DNA-proflavine complexes
16. DNA stiffening and elongation caused by the binding of ethidium bromide
17. A molecular model for the interaction of ethidium bromide with Deoxyribonucleic Acid
18. The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline caesium chloride density gradients
19. On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy
20. The sense of naturally-occurring superhelices and the unwinding angle of intercalated ethidium
21. A non-intercalating proflavine derivative
22. Potential antitumour agents. 12. 9-Anilinoacridines
23. An assessment of the immunosuppressive activity of the anti-tumour compound 4′-[(9-acridinyl)amino] methanesulphon-m-anisidide (m-AMSA)