Prospective Comparison of Indirect Methods for Detecting Lactase Deficiency

New England Journal of Medicine

Volumn 293, Issue 24, 1975, Pages 1232-1236

  Newcomer, Albert D ^a   McGill, Douglas B ^a   Thomas, Paul J ^a   Hofmann, Alan F ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; LACTOSE C 14; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; DIAGNOSIS; ENZYME DEFICIENCY; GLUCOSE BLOOD LEVEL; INTESTINE BIOPSY; METHODOLOGY;

EID: 0016698185     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM197512112932405     Document Type: Article

References (23)

1. Cuatrecasas P, Lockwood DH, Caldwell JR: Lactase deficiency in the adult: a common occurrence. Lancet 1: 14–18, 1965
2. Haemmerli UP, Kistler H, Ammann R, et al: Acquired milk intolerance in the adult caused by lactose malabsorption due to a selective deficiency of intestinal lactase activity. Am J Med 38: 7–30, 1965
3. Bayless TM, Rosensweig NS: A racial difference in incidence of lactase deficiency: a survey of milk intolerance and lactase deficiency in healthy adult males. JAMA 197: 968–972, 1966
4. McGill DB, Newcomer AD: Comparison of venous and capillary blood samples in lactose tolerance testing. Gastroenterology 53: 371–374, 1967
5. Welsh JD: Isolated lactase deficiency in humans: report on 100 patients. Medicine (Baltimore) 49: 257–277, 1970
6. Isokoski M, Jussila J, Sarna S: A simple screening method for lactose malabsorption. Gastroenterology 62: 28–32, 1972
7. Kern F Jr, Heller M: Blood galactose after lactose and ethanol: an accurate index of lactase deficiency. Gastroenterology 54: 1250, 1968
8. Salmon PR, Read AE, McCarthy CF: An isotope technique for measuring lactose absorption. Gut 10: 685–689, 1969
9. Sasaki Y, Iio M, Kameda H, et al: Measurement of 14C-lactose absorption in the diagnosis of lactase deficiency. J Lab Clin Med 76: 824–835, 1970
10. Calloway DH, Murphy EL, Bauer D: Determination of lactose intolerance by breath analysis. Am J Dig Dis 14: 811–815, 1969
11. Levitt MD, Donaldson RM: Use of respiratory hydrogen (H2) excretion to detect carbohydrate malabsorption. J Lab Clin Med 75: 937–945, 1970
12. Dahlqvist A: Method for assay of intestinal disaccharidases. Anal Biochem 7: 18–25, 1964
13. Newcomer AD, McGill DB: Distribution of disaccharidase activity in the small bowel of normal and lactase-deficient subjects. Gastroenterology 51: 481–488, 1966
14. Newcomer: Disaccharidase activity in the small intestine: prevalence of lactase deficiency in 100 healthy subjects. Gastroenterology 53: 881–889, 1967
15. Levitt MD: Production and excretion of hydrogen gas in man. N Engl J Med 281: 122–127, 1969
16. Fromm H, Hofmann AF: Breath test for altered bile-acid metabolism. Lancet 2: 621–625, 1971
17. Shreeve WW, Cerasi E, Luft R: Metabolism of [2–14C] pyruvate in normal, acromegalic and high treated human subjects. Acta Endocrinol (Kbh) 65: 155–169, 1970
18. Wallenfels K, Kurz G: Über die Spezifitåt der Galaktosedehydrogenase aus Pseudomonas saccharophila und deren Anwendung als analytisches Hilfsmittel. Biochem Z 335: 559–572, 1962
19. Jussila J: Diagnosis of lactose malabsorption by the lactose tolerance test with peroral ethanol administration. Scand J Gastroenterol 4: 361–368, 1969
20. Levitt MD, Ingelfinger FJ: Hydrogen and methane production in man. Ann NY Acad Sci 150: 75–81, 1968
21. Levitt MD: Volume and composition of human intestinal gas determined by means of an intestinal washout technic. N Engl J Med 284: 1394–1398, 1971
22. Bond JH, Levitt MD: Quantitative measurement of lactose malabsorption. Clin Res 22: 601, 1974
23. Newcomer AD, Thomas PJ, McGill DB, et al: Comparison of methods to detect lactase deficiency. Gastroenterology 66: 754, 1974