Nervous System Degeneration Produced by the Industrial Solvent Methyl n-Butyl Ketone

Archives of Neurology

Volumn 32, Issue 4, 1975, Pages 219-222

  Spencer, Peter S ^a   Schaumburg, Herbert H ^a   Raleigh, Robert L ^b   Terhaar, Clarence J ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b EASTMAN KODAK COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYL 2 PENTANONE; SOLVENT;

DOSE RESPONSE; DRUG COMPARISON; DRUG RESPONSE; DRUG TOXICITY; ELECTRON MICROSCOPY; HISTOLOGY; INHALATIONAL DRUG ADMINISTRATION; MICROSCOPY; MUSCLE WEAKNESS; NERVE CELL; NERVE CELL DEGENERATION; NERVE FIBER DEGENERATION; NERVOUS SYSTEM; NEUROFILAMENT; NEUROTOXICITY; NEUROTUBULE; POLYNEUROPATHY; PRINTING; RAT; TEXTILE INDUSTRY; THEORETICAL STUDY; TOXIC NEUROPATHY;

ANIMAL; AXONS; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; KETONES; MYELIN SHEATH; NERVE FIBERS, MYELINATED; NERVOUS SYSTEM DISEASES; OCCUPATIONAL MEDICINE; PERIPHERAL NERVES; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0016612705     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.1975.00490460035002     Document Type: Article

References (20)

1. Allen N, Mendell JR, Billamier D, et al: An outbreak of a previously undescribed toxic polyneuropathy due to an industrial solvent. Trans Am Neurol Assoc, to be published.
2. Schrenk HH, Yant WP, Patty FA: Public Health Report, No. 51. Public Health Service, 1936, p 624.
3. Specht H, Miller JW, Valaer PJ, et al: National Institutes of Health Bulletin, No. 176. National Institutes of Health, 1940.
4. Federal Register 39:125, pt 11, section 1910. 93, subpart, 6, Occupational Safety and Health Administration, June 27, 1974.
5. McDonough JR: Possible neuropathy from methyl n-butyl ketone. N Engl J Med 290:695, 1974.
6. Spencer PS, Schaumburg HH: Experimental methyl n-butyl ketone neuropathy. Read before the 50th annual meeting of the American Association of Neuropathologists, Boston, 1974.
7. Spencer PS, Thomas PK: The examination of isolated nerve fibers by light and electron microscopy with observations on demyelination proximal to amputation neuromas. Acta Neuropathol 16:177-186, 1970.
8. Spencer PS, Thomas PK: Ultrastructural studies of the dying-back process: II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons. J Neurocytol, to be published.
9. Cavanagh JB: The significance of the “dying-back” process in experimental and human neurological diseases. Int Rev Exp Pathol 3:219-267, 1964.
10. Prineas J: The pathogenesis of dying-back polyneuropathies: 1. An ultrastructural study of experimental acrylamide intoxication in the cat. J Neuropathol Exp Neurol 28:571-597, 1969.
11. Prineas J: The pathogenesis of dying-back polyneuropathies: II. An ultrastructural study of experimental tri-ortho cresyl phosphate intoxication in the cat. J Neuropathol Exp Neurol 28:598-621, 1969.
12. Cavanagh JB: Toxic substances and the nervous system. Br Med Bull 25:268-273, 1969.
13. Cavanagh JB: Peripheral neuropathy caused by chemical agents. CRC Crit Rev Toxicol 2:365-417, 1973.
14. Schaumburg HH, Wiśniewski H, Spencer PS: Ultrastructural studies of the dying-back process: 1. Peripheral nerve terminal and axon degeneration in systemic acrylamide intoxication. J Neuropathol Exp Neurol 33:260-284, 1974.
15. Spencer PS, Schaumburg HH: A review of acrylamide neurotoxicity: 2. Experimental animal neurotoxicity and pathologic mechanisms. Can J Neurol Sci 1:152-169, 1974.
16. Asbury AK, Nielsen SL, Telfer R: Gluesniffing neuropathy. J Neuropathol Exp Neurol 33:191, 1974.
17. Herskowitz A, Ishii N, Schaumburg H: Nhexane neuropathy: A syndrome occurring as a result of industrial exposure. N Engl J Med 265:82-85, 1971.
18. Ishii N, Herskowitz A, Schaumburg HH: Nhexane polyneuropathy: A clinical and experimental study. J Neuropathol Exp Neurol 31:198, 1972.
19. Shirabe T, Tsuda T, Terao A, et al: Toxic polyneuropathy due to glue-sniffing: Report of two cases with light and electron microscopic study of the peripheral nerves and muscles. J Neurol Sci 21:101-113, 1974.
20. Asbury AK, Gale MK, Cox SC, et al: Giant axonal neuropathy: A unique case with segmental neurofilamentous masses. Acta Neuropathol 20:237-247, 1972.