Physicochemical-Activity Relations in Practice. 1. A Rational and Self-Consistent Data Bank

Journal of Medicinal Chemistry

Volumn 18, Issue 6, 1975, Pages 604-607

  Norrington, Franklin E ^a   Hyde, Richard M ^a   Williams, Stanley G ^a   Wootton, Raymond ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; PHENOL DERIVATIVE;

LIPOPHILICITY; ARTICLE; INFORMATION SYSTEM; KINETICS; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHYSICAL; INFORMATION SYSTEMS; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0016592909     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00240a016     Document Type: Article

References (25)

1. C. Hansch and T. Fujita, J. Am. Chem. Soc., 86, 1616 (1964).
2. C. Hansch, A. Leo, S. H. Unger, K. H. Kim, D. Nikaitani, and E. J. Lien, J. Med. Chem., 16, 1207 (1973).
3. M. S. Tute, Adv. Drug Res., 6, 1 (1971).
4. P. J. Goodford, Adv. Pharmacol. Chemother., 11, 51 (1973).
5. R. M. Hyde, F. E. Norrington, S. G. Williams, and R. Wootton, manuscript in preparation.
6. P. N. Craig, J. Med. Chem., 14, 680 (1971).
7. T. Fujita, J. Iwasa, and C. Hansch, J. Am. Chem. Soc., 86, 5175 (1964).
8. C. Hansch, and W. J. Dunn, J. Pharm. Sci., 61, 1 (1972).
9. C. Hansch and J. M. Clayton, J. Pharm. Sci., 62, 1 (1972).
10. A. E. Bird and A. C. Marshall, Biochem. Pharmacol., 16, 2275 (1967).
11. L. P. Hammett, Chem. Rev., 17, 125 (1935).
12. R. Taft, “Steric Effects in Organic Chemistry”, M. S. Newman, Ed., Wiley, New York, N.Y., 1956.
13. C. G. Swain and E. C. Lupton, J. Am. Chem. Soc., 90, 4328(1968).
14. S. G. Williams and F. E. Norrington, in press.
15. A. Cammarata, Annu. Rep. Med. Chem., 245 (1971).
16. E. Kutter and C. Hansch, J. Med. Chem., 12, 647 (1969).
17. R. W. Fuller, M. Marsh, and J. Mills, J. Med. Chem., 11, 397 (1968).
18. A. Leo, C. Hansch, and C. Church, J. Med. Chem., 12, 766(1969).
19. J. C. McGowan, J. Appl. Chem., 4, 41 (1954).
20. A. I. Vogel, J. Chem. Soc., 607 (1948).
21. A. I. Vogel, J. Chem. Soc., 1809 (1948).
22. D. Gilbert, P. J. Goodford, F. E. Norrington, B. C. Weatherley, and S. G. Williams, in press.
23. G. Berlin and D. D. Perrin, Q. Rev., Chem. Soc., 20, 75 (1966).
24. J. Clark and D. D. Perrin, Q. Rev., Chem. Soc., 18, 295 (1964).
25. A. Leo, C. Hansch, and D. Elkins, Chem. Rev., 71, 525 (1971).