Amputation and Adriamycin in Primary Osteosarcoma

New England Journal of Medicine

Volumn 291, Issue 19, 1974, Pages 998-1000

  Cortes, Engracio P ^a   Holland, James F ^a   Wang, Jaw J ^a   Sinks, Lucius F ^a   Blom, Johannes ^a   Senn, Hansjurg ^a   Bank, Arthur ^a   Glidewell, Oliver ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN;

ADVERSE DRUG REACTION; ALOPECIA; AMPUTATION; CANCER CHEMOTHERAPY; ELECTROCARDIOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; LIMB AMPUTATION; LUNG METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; NAUSEA; OSTEOSARCOMA; STOMATITIS; THERAPY; THROMBOCYTOPENIA; TUMOR; VOMITING;

EID: 0016208984     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM197411072911903     Document Type: Article

References (21)

1. Friedman MA, Carter SK: The therapy of osteogenic sarcoma: current status and thoughts for the future. J Surg Oncol 4: 482–510, 1972
2. Marcove RC, Mike V, Hajek JV, et al: Osteogenic sarcoma in childhood. NY State J Med 71: 855–859, 1971
3. Sweetnam R, Knowelden J, Seddon H: Bone sarcoma: treatment by irradiation, amputation or a combination of the two. Br Med J 2: 363–367, 1971
4. Brenhovd IO, Roger V, Hoeg K: Circulating tumor cells in osteosarcoma, Colston Paper No. 24: Bone-certain aspects of neoplasia. Edited by CHG Price, FGM Ross. London, Buttersworth and Company, 1972, pp 245–249
5. Jaffe N, Paed D: Recent advances in the chemotherapy of metastatic osteogenic sarcoma. Cancer 30: 1627–1631, 1972
6. Blum RH, Carter SK: Adriamycin: a new anticancer drug with significant clinical activity. Ann Intern Med 80: 249–259, 1974
7. Cortes EP, Holland JF, Wang JJ, et al: Chemotherapy of advanced osteosarcoma, Colston Paper No. 24: Bone-certain aspects of neoplasia. Edited by CHG Price, FGM Ross, London, Buttersworth and Company, 1972, pp 265–280
8. McKenna RJ, Schwinn CP, Soong KY, et al: Sarcoma of the osteogenic series: (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): an analysis of 552 cases. J Bone Joint Surg [Am] 48: 1–26, 1966
9. Skipper HE, Schabel FM Jr., Wilcox WS: Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with “curability” of experimental leukemia. Cancer Chemother Rep 35: 1–111, 1964
10. Wilcox WS, Griswold DP, Laster WR Jr., et al: Experimental evaluation of potential anticancer agents. XVII. Kinetics of growth and regression after treatment of certain solid tumors. Cancer Chemother Rep 47: 27–39, 1965
11. Laster WR Jr., Mayo JG, Simpson-Herren L, et al: Success and failure in the treatment of solid tumors. II. Kinetic parameters and “cell cure” of moderately advanced carcinoma 755. Cancer Chemother Rep 53: 169–188, 1969
12. Fernbach DJ, Mastyn DT: Role of dactinomycin in the improved survival of children with Wilms' tumor. JAMA 195: 1005–1009, 1966
13. Lewis RJ, Lotz MJ: Medullary extension of osteosarcoma: implications for rational therapy. Cancer 33: 371–375, 1974
14. Sweetnam R, Ross K: Surgical treatment of pulmonary metastases from primary tumours of bone. J Bone Joint Surg [Br] 49: 74–79, 1967
15. Cortes EP, Lutman G, Wanka J, et al: Adriamycin cardiotoxicity in adults with cancer. Clin Res 21: 412, 1973
16. LeFrak EA, Pǐtha J, Rosenheim S, et al: A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32: 302–314, 1973
17. Jaffe N, Frei E III, Traggis D, et al: Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N Engl J Med 291: 994–997, 1974
18. Rosen G, Tan C, et al: Vincristine (VCR), high dose methotrexate (HDMTX) with citrovorum factor (CF) rescue, cyclophosphamide (CY), and adriamycin (ADR) cyclic therapy following surgery in childhood osteogenic sarcoma. Proc Am Assoc Cancer Res 15: 172, 1974
19. Sutow WW, Sullivan MP, Fernbach DJ: Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. Proc Am Assoc Cancer Res 15: 20, 1974
20. Pratt CB, Hustu HO, Shanks E: Cyclic multiple drug adjuvant chemotherapy for osteosarcoma. Proc Am Assoc Cancer Res 15: 19, 1974
21. Wilbur JR, Etcubanas E, Long T, et al: 4 drug therapy and irradiation in primary and metastatic osteogenic sarcoma. Proc Am Assoc Cancer Res 15: 188, 1974