Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite

Pharmacology

Volumn 11, Issue 3, 1974, Pages 151-169

  Jollow, David ^a   Mitchell, J R ^a   Zampaglione, N ^a   Gillette, J R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

3,4 Bromobenzene oxide; Bromobenzene; Glutathione; Liver necrosis; Protective mechanism; Toxic dose threshold; Toxic metabolite

Indexed keywords

BROMOBENZENE; CYSTEINE; GLUTATHIONE; MALEIC ACID DIETHYL ESTER; PHENOBARBITAL; PROADIFEN; RADIOISOTOPE;

BROMOBENZENE C 14; BROMOBENZENE DERIVATIVE; CYTOLOGY; DOSE LIVER FUNCTION RELATION; DRUG METABOLISM; DRUG TOXICITY; EPOXIDATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; RAT; THEORETICAL STUDY; URINE;

ANIMAL; BENZENE DERIVATIVES; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CYSTEINE; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLUTATHIONE; HYDROCARBONS, BROMINATED; IN VITRO; LIVER; LIVER DISEASES; MALE; MALEATES; MICROSOMES, LIVER; NECROSIS; OXIDATION-REDUCTION; PHENOBARBITAL; PROADIFEN; PROTEIN BINDING; RATS;

EID: 0016151122     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000136485     Document Type: Article

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