Disposition and Metabolism of 4-Methyl-2-(4-phenylbenzyl)-2-oxazoline-4-methanol in the Rat and Dog

Journal of Medicinal Chemistry

Volumn 17, Issue 1, 1974, Pages 45-48

  Turnbull, Lennox B ^a   Johnson, Christopher P ^a   Chen, Ying Ho ^a   Sancilio, Lawrence F ^a   Bruce, Robert B ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHANOL 4 METHYL 2 (4 PHENYLBENZYL) 2 OXAZOLINE C 14; BIPHENYL DERIVATIVE; OXAZOLINE DERIVATIVE; PHENYLBUTAZONE; UNCLASSIFIED DRUG;

ARTICLE; DOG; DRUG ANALYSIS; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SYNTHESIS; DRUG URINE LEVEL; FECES; HYDROLYSIS; MASS SPECTROMETRY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RAT; THEORETICAL STUDY; THIN LAYER CHROMATOGRAPHY; URINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AUTORADIOGRAPHY; BIPHENYL COMPOUNDS; CARBON RADIOISOTOPES; CARRAGEENAN; CHROMATOGRAPHY, THIN LAYER; DOGS; FECES; FEMALE; GASTRIC JUICE; MASS SPECTROMETRY; METHANOL; OXAZOLES; PHENYLBUTAZONE; PLEURAL EFFUSION; RATS;

EID: 0015962891     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00247a010     Document Type: Article

References (15)

1. W. A. Cressman, C. A. Janicki, P. C. Johnson, J. T. Doluisio, and G. A. Braun, J. Pharm. Sci., 58, 1516 (1969).
2. L. B. Turnbull, J. Newman, and R. B. Bruce, Abstracts, 21st Southeastern Regional Meeting of the American Chemical Society, 1969, No. 263.
3. J. A. Morrison, Arch. Int. Pharmacodyn., 157, 385 (1965).
4. W. G. Dauben, J. C. Reid, and P. E. Yankevich, Anal. Chem., 19, 828(1947).
5. I. Smith, “Chromatographic and Electrophoretic Techniques.” Vol. 1, Interscience, New York, N. Y., 1960, p 280.
6. D. W. Thomas, B. C. Das, S. D. Géro, and E. Lederer, Biochem. Biophys. Res. Commun., 32, 199(1968).
7. L. F. Sancilio and A. Fishman, Fed. Proc., Fed. Amer. Soc. Exp. Biol., 30, 563 (1971).
8. J. A. Frump, Chem. Rev., 71, 483 (1971).
9. W. H. Hartung, J. C. Munch, and E. B. Kester, J. Amer. Chem. Soc., 54, 1526 (1932).
10. R. E. McMahon, A. S. Ridolfo, H. W. Culp, R. L. Wolen, and F. J. Marshall, Toxicol. Appl. Pharmacol., 19, 427 (1971).
11. J. R. Reasenberg and S. D. Goldberg, J. Amer. Chem. Soc., 67, 933 (1945).
12. B. N. LaDu, H. G. Mandel, and E. L. Way, “Fundamentals of Drug Metabolism,” Williams and Wilkins. Baltimore. Md., 1971. p 164.
13. E. Boyland, G. S. Ramsey, and P. Sims, Biochem. J., 78, 376(1961).
14. M. O. James, R. L. Smith, R. T. William, F. R. S. Reidenberg, and M. Reidenberg, Proc. Roy. Soc., Ser. B. 182, 25 (1972).
15. E. Boyland, G. S. Ramsey, and P. Sims, Biochem. J. p 189.