Quabain: Temporal relationship between the inotropic effect and the in vitro binding to, and dissociation from, (Na++K+)-activated ATPase

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 277, Issue 2, 1973, Pages 151-162

  Akera, T ^a   Baskin, S I ^a   Tobin, T ^a   Brody, T M ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

(Na++K+) Activated ATPase; Cardiac Glycosides; Positive Inotropic Effect

Indexed keywords

ADENOSINE TRIPHOSPHATASE; OUABAIN; POTASSIUM; SODIUM; TRITIUM;

ANIMAL; ARTICLE; BINDING SITE; CAT; CHEMISTRY; DOG; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GUINEA PIG; HEART; HEART MUSCLE; IN VITRO STUDY; METABOLISM; PERFUSION; PHYSIOLOGY; RABBIT; SPECIES DIFFERENCE;

ADENOSINETRIPHOSPHATASE; ANIMAL; BINDING SITES; CATS; CHEMISTRY; DOGS; ENZYME ACTIVATION; GUINEA PIGS; HEART; IN VITRO; MYOCARDIUM; OUABAIN; PERFUSION; POTASSIUM; RABBITS; SODIUM; SPECIES SPECIFICITY; TRITIUM;

EID: 0015551194     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/BF00501156     Document Type: Article

References (35)

1. Quantitative aspects of the interaction between ouabain and (Na++K+)-activated ATPase in vitro
2. Membrane adenosine triphosphatase: The effect of potassium on the formation and dissociation of the ouabain-enzyme complex
3. The effect of ouabain on sodium- and potassium-activated adenosine triphosphatase from the hearts of several mammalian species
4. Correlation of cardiac sodium- and potassium-activated adenosine triphosphatase activity with ouabain-induced inotropic stimulation
5. The binding of tritiated ouabain to sodium- and potassium-activated adenosine triphosphatase and cardiac relaxing system of perfused dog heart
6. The nature of the transport ATPasedigitalis complex II. Some species differences and ouabain “exchange” characteristics
7. An allosteric explanation for ouabain-induced time-dependent inhibition of sodium-, potassium-adenosine triphosphatase
8. A possible biochemical explanation for the insensitivity of the rat to cardiac glycosides
9. The relationship between phosphorus metabolism and the sodium pump in intact crab nerve
10. Potassium ions and the binding of cardiac glycosides to mammalian cells
11. Correlation between the inotropic action of ouabain and its effect on subcellular enzyme systems from canine myocardium
12. Influence of potassium depletion on myocardial concentration of tritiated digoxin
13. Subcellular distribution of digoxin-H3 in isolated guinea-pig and rat hearts
14. Factors that regulate ouabain accumulation by the isolated guinea-pig heart
15. Species and ionic influences on the accumulation of digitalis glycosides by isolated perfused hearts
16. The effect of increased serum potassium on the digoxin content of the canine heart
17. Über die Wirkung von Strophanthidin-3-bromacetat am Papillarmuskel des Meerschweinchens
18. Die Haftung verschiedener Cardenolide am Papillarmuskel und einer mikrosomalen ATPase des Meerschweinchenherzens
19. Mutual exclusion of ATP, ADP and g-strophanthin binding to NaK-ATPase
20. Myocardial digoxin-3H content in experimental hypokalemic cardiomyopathy
21. Inhibition of binding of tritiated digoxin to myocardium by sodium depletion in dogs
22. The red cell membrane and the transport of sodium and potassium
23. Protein measurement with the Folin phenol reagent
24. The correlation between the decline of the positive inotropic effect and the loss of cardiac glycosides from isolated atria during washout
25. Mechanism of cardiac glycoside inhibition of the (Na++K+)-dependent ATPase from cardiac tissue
26. Influence of extracellular potassium concentration on myocardial uptake and inotropic effect of tritiated digoxin
27. Über die Ursache der Speciesunterschiede in der Digitalisempfindlichkeit
28. Relationship among contraction, drug binding and positive inotropic action of digoxin
29. On the positive inotropic action of alkylating bromoacetates of strophanthidin and strophanthidol-(10-H3)
30. Possible involvement of cardiac Na+, K+-adenosine triphosphatase in the mechanism of action of cardiac glycosides
31. Tritiated digoxin binding to (Na++K+)-activated adenosine triphosphatase: possible allosteric site
32. Rates of dissociation of enzyme-ouabain complexes and K0.5 values in (Na++K+)-adenosine triphosphatase from different species
33. Species and tissue differences in the rate of dissociation of ouabain from (Na++K+)-ATPase
34. The assymetrical stimulation of a membrane ATPase in relation to active cation transport