Depression and MHPG Excretion: Response to Dextroamphetamine and Tricyclic Antidepressants

Archives of General Psychiatry

Volumn 26, Issue 3, 1972, Pages 246-251

  Fawcett, Jan ^a,b   Maas, James W ^a,b   Dekirmenjian, Haroutune ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b International Educational Leadership Centre   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CATECHOL DERIVATIVE; DESIPRAMINE; DEXAMPHETAMINE; GLYCOL; IMIPRAMINE; NORADRENALIN; PLACEBO; SULFATE;

ADULT; AFFECT; ARTICLE; BRAIN LEVEL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; PROGNOSIS; PSYCHOLOGIC TEST; URINE;

ADULT; AFFECT; ANTIDEPRESSIVE AGENTS; BRAIN CHEMISTRY; CATECHOLS; COMPARATIVE STUDY; DEPRESSION; DESIPRAMINE; DEXTROAMPHETAMINE; EVALUATION STUDIES; FEMALE; GLYCOLS; HUMAN; IMIPRAMINE; MALE; MIDDLE AGE; NOREPINEPHRINE; PLACEBOS; PROGNOSIS; PSYCHOLOGICAL TESTS; SULFATES;

EID: 0015309725     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1972.01750210054011     Document Type: Article

References (23)

1. Schildkraut JJ: Catecholamine hypothesis of affective disorders: Review of supporting evidence. Amer J Psychiat 122:509-522, 1965.
2. Bunney WE Jr, Davis JM: Norepinephrine in depressive reactions: review. Arch Gen Psychiat 13:483-494, 1965.
3. Schildkraut JJ, Gordon EK, Durell J: Catecholamine metabolism in affective disorders: I. Normetanephrine and VMA excretion in depressed patients treated with imipramine. J Psychiat Res 3:213-228, 1965.
4. Maas JW, Landis DH: In vivo studies of the metabolism of norepinephrine in the central nervous system. J Pharmacol Exp Ther 163:147-162, 1968.
5. Mannarino E, Kirshner N, Nashold BS: The metabolism of [C14] noradrenaline by cat brain in vivo. J Neurochem 10:373-379, 1963.
6. Schanberg SM, Schildkraut JJ, Kopin IJ: (NM-H3) turnover and conversion to a deaminated conjugate as a major metabolite in rat brain. Biochem Pharmacol 17:247-254, 1968.
7. Maas JW, Landis DH: A technique for assaying the kinetics of norepinephrine metabolism in the central nervous system in vivo. Psychosom Med 28:247-256, 1966.
8. Maas JW, Fawcett J, Dekirmenjian H: 3-Methoxy-4-hydroxy phenylglycol (MHPG) excretion in depressive states: A pilot study. Arch Gen Psychiat 19:129-134, 1968.
9. Greenspan K, Schildkraut J, Gordon E, et al: Catecholamine metabolism in affective disorders: III. MHPG and other catecholamine metabolites in patients treated with lithium carbonate. J Psychiat Res 7:171-184, 1970.
10. Carlsson A, Fuxe K, Hamberger B, et al: Biochemical and histochemical studies on effects of imipramine-like drugs and (+) amphetamine on central and peripheral catecholamine neurons. Acta Physiol Scand 67:481-497, 1966.
11. Glowinski J, Axelrod J, Iversen LL: Regional studies of catecholamines in rat brain: IV. Effects of drugs on disposition and metabolism of H3-norepinephrine and H3-dopamine. J Pharmacol Exp Ther 153:30-41, 1966.
12. Sulser F, Owens ML, Norvich MR, et al: Relative role of storage and synthesis of brain norepinephrine in psychomotor stimulation evoked by amphetamine or by desimipramine and tetrabenazine. Psychopharmacologia 12:322-332, 1968.
13. Hanson LCF: Evidence that the central action of (+)-amphetamine is mediated via catecholamine. Psychopharmacologia 10:289-297, 1967.
14. Rutledge CO: The mechanisms by which amphetamine inhibits oxidative deamination of norepinephrine in brain. J Pharmacol Exp Ther 171:188-195, 1970.
15. Fawcett J, Siomopoulos V: Dextroamphetamine response as a possible predictor of improvement with tricyclic therapy in depression. Arch Gen Psychiat.
16. Maas JW, Fawcett J, Dekirmenjian H: Catecholamine metabolism and the depressive states. Read before the annual meeting of the American Psychiatric Association, Boston, 1968.
17. Lyerly SB, Abbott PS: Handbook of Psychiatric Rating Scales (1950-1964), Public Health Service publication No. 1495, US Department of Health, Education, and Welfare.
18. Bunney WE Jr, Mason JW, Hamburg DA: Correlations between behavioral variables and urinary 17-hydroxycorticosteroids in depressed patients. Psychosom Med 27:299-308, 1965.
19. Wilk S, et al: Determination of urinary 3-methoxy-4-hydroxyphenylethylene glycol by gas-liquid chromatography and electron capture detection. Clin Chim Acta 16:403, 1967.
20. Dekirmenjian H, Maas JW: An improved procedure of 3methoxy-4-hydroxyphenylethylene glycol determination by gasliquid chromatography. Anal Biochem 35:113-122, 1970.
21. Bonsnes RW, Taussky HH: On the colorimetric determination of creatinine by the Jaffe reaction. J Biol Chem 158:581, 1945.
22. Bunney WE Jr, Brodie HKH, Murphy DL, et al: Studies of alpha-methyl-para-tryosine, L-DOPA, and L-tryptophan in depression and mania. Amer J Psychiat 127:872-881, 1971.
23. Maas JW, Fawcett JA, Dekirmenjian H, et al: Catecholamine metabolism and depressive states, in: NIMH Workshop on Recent Advances in the Psychobiology of Depressive Illness, to be published.