DISCUSSION PAPER: L‐ASPARAGINASE INDUCED ALTERATION OF AMETHOPTERIN (METHOTREXATE) ACTIVITY IN MOUSE LEUKEMIA L5178Y

Annals of the New York Academy of Sciences

Volumn 186, Issue 1, 1971, Pages 302-311

  Capizzi, Robert L ^a   Summers, Wilma P ^a   Bertino, Joseph R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; ASPARAGINE; DEOXYURIDINE; DNA; METHOTREXATE; TRITIUM;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; EXPERIMENTAL LEUKEMIA; FEMALE; METABOLISM; MOUSE; MOUSE STRAIN; TIME;

ANIMAL; ASPARAGINASE; ASPARAGINE; CELL SURVIVAL; CELLS, CULTURED; DEOXYURIDINE; DNA, NEOPLASM; FEMALE; LEUKEMIA, EXPERIMENTAL; METHOTREXATE; MICE; MICE, INBRED STRAINS; TIME FACTORS; TRITIUM;

EID: 0015246397     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1971.tb46985.x     Document Type: Article

References (40)

1. Studies on unbalanced growth in Escherichia coli.
2. The isolation and properties of amino acid requiring mutants of a thymineless bacterium
3. Control and synthesis of macromolecules during aminoacid and thymine starvation in Bacillis subtilis.
4. Thymine deficiency and the normal DNA replication cycle I
5. Role of protein synthesis in the DNA replication cycle in bacteria
6. Studies on the propagation of poliomyelitis viruses
7. A method of selecting for auxotrophic mutants of HeLa cells
8. Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency
9. Studies on unbalanced growth in synchronized HeLa cells
10. Growth inhibition of a human tumor cell strain by 5‐fluoro‐2′‐deoxyuridine. Time parameters for subsequent reversal by thymidine
11. Growth inhibition of a human tumor cell strain by 5‐fluorocytidine and 5‐fluoro‐2′‐deoxycytidine
12. Growth and nucleic acid synthesis in synchronously dividing population of HeLa cells
13. Action of 1‐β‐D‐arabinofuranosylcytosine on the nucleic acid metabolism and viability of HeLa cells
14. Cell viability and nucleic acid metabolism after exposure of HeLa cells to excess thymidine and deoxyadenosine
15. Some effects of D‐arabinosyl nucleosides on polymer syntheses in mouse fibroblasts
16. Action of hydroxyurea on the nucleic acid metabolism and viability of HeLa cells
17. Correlation between cell enlargement and nucleic acid and protein content of HeLa cells in unbalanced growth produced by inhibition of DNA synthesis
18. Recovery from prolonged unbalanced growth induced in HeLa cells by high concentration of thymidine
19. Cell killing studies on the mode of action of Methotrexate on L‐cells in vitro.
20. The requirement for L‐asparagine of mouse leukemia cells L5178Y in culture
21. A metabolic difference between two lines of lymphoma 6C3HED cells in relation to Asparagine
22. Differences in the production of L‐Asparagine in Asparaginase‐sensitive and resistant lymphoma cells
23. Studies on the mechanism of tumor inhibition by L‐Asparaginase
24. The dependence of DNA and RNA synthesis on protein synthesis in Asparaginase‐treated lymphomas cells
25. L‐Asparaginase: Inhibition of early mitosis in regenerating rat liver
26. L‐Asparaginase: Inhibition of endogenous RNA polymerase activity in regenerating liver
27. Development, maintenance and assay of drug resistance
28. 3H‐cytosine arabinoside and its effect on murine leukemic cells (L5178Y)
29. The mechanism of action of the folate antagonists in man
30. Treatment of leukemia with large doses of Methotrexate and folinic acid: clinical‐biochemical correlates
31. The normal DNA replication cycle II
32. S‐phase cells of rapidly growing and resting populations
33. Probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard or X‐irradiation
34. Two L‐Asparaginases from Escherichia coli B. their separation, purification and antitumor activity
35. The antitumor activity of Escherichia coli L‐Asparaginase
36. L‐asparagine biosynthesis by nutritional variants of the Jensen sarcoma
37. Asparagine synthetase in Asparaginase resistant and susceptible mouse lymphomas
38. Asparagine synthetase activity of mouse leukemias
39. Inhibition of in vitro uptake of Methotrexate by L‐Asparaginase in L5178Y murine leukemia cells