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Volumn 169, Issue 3950, 1970, Pages 1042-1049

A theory of self-nonself discrimination

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BOVINE SERUM ALBUMIN; EPITOPE; HAPTEN; ISOENZYME; LACTATE DEHYDROGENASE; SERUM ALBUMIN;

EID: 0014941813     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.169.3950.1042     Document Type: Article
Times cited : (1399)

References (59)
  • 15
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    • There are cases in which the injection of low-molecular-weight compounds like arsanilic L-AT-acetyltyrosine
    • or dinitrophenyl hepta-L-lysine
    • (1967) Science , vol.155 , pp. 350
    • Leskowitz, S.1
  • 16
    • 0013795180 scopus 로고
    • Although it could be argued that two properly spaced determinants are sufficient for induction and that these compounds meet this requirement, such an interpretation is probably not correct
    • practice, more than two foreign determinants are probably necessary to induce a measurable response. It is more likely that these substances are aggregated in vivo by interaction with themselves or with the animal's components.
    • (1965) Biochemistry , vol.4 , pp. 1638
    • Schlossman, S.F.1    Yaron, A.2    Ben-Efraim, S.3    Sober, H.A.4
  • 45
    • 0014943238 scopus 로고
    • However, because of its great stability due to co-operative binding
    • Although stretching has been considered a possible component of the inductive signal, the minimal theory analyzed here does not require this [for discussion of this point, see (4)]
    • (1970) Ann. N.Y. Acad. Sci. , vol.169 , pp. 56
    • Karush, F.1
  • 48
    • 0013869740 scopus 로고
    • As the antigen concentration is increased into the high-zone paralytic range, the rupture of a bigamous bridge will take place at roughly the same concentration as that at which rupture of a monogamous bridge occurs.
    • (1966) Immunology , vol.10 , pp. 81
    • Mäkelä, O.1
  • 56
    • 85027786312 scopus 로고
    • These considerations also show that an antigen cannot interact with a “stem cell,” which possesses receptors of very many different kinds, to provide a signal for the cell to differentiate into a unispecific cell
    • as proposed by and
    • (1970) Folia Biol. (Praha) , vol.16 , pp. 1
    • Brondz, B.D.1    Goldberg, N.E.2
  • 57
    • 85027827622 scopus 로고
    • The formulation of our theory, as presented here, corrects and supersedes any previously published accounts-that is
    • (1968) Nature , vol.220 , pp. 444
    • Bretscher, P.A.1    Conn, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.