Metastasis: Quantitative analysis of distribution and fate of tumor emboli labeled with 125l-5-lodo-2'-deoxyuridine

Journal of the National Cancer Institute

Volumn 45, Issue 4, 1970, Pages 773-782

  Fidler, Isaiah J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IDOXURIDINE; IODINE;

ANIMAL; ARTICLE; AUTORADIOGRAPHY; CELL CLONE; EXPERIMENTAL NEOPLASM; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LUNG TUMOR; MELANOMA; METASTASIS; MOUSE; PATHOPHYSIOLOGY; TECHNIQUE; TIME; TISSUE CULTURE;

ANIMAL; AUTORADIOGRAPHY; CLONE CELLS; IDOXURIDINE; IN VITRO; INJECTIONS, INTRAVENOUS; IODINE ISOTOPES; LUNG NEOPLASMS; MELANOMA; METHODS; MICE; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; TIME FACTORS; TISSUE CULTURE;

EID: 0014865396     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/45.4.773     Document Type: Article

References (42)

1. Baserga R, Kisieleski WE, Halversen K: A study on the establishment and growth of tumor metas- tascs with tritiated thymidine. Cancer Res 20:910-917, 1960
2. Fisher B, Fisher ER: The interrelationship of hematogenous and lymphatic tumor cell dissemination. Surg Gynec Obstet 122:791-798, 1966
3. Fisher B, Fisher ER: Metastases of cancer cells. In Methods of Cancer Research. New York, Academic Press Inc., 1967, pp 243-286
4. Fisher B, Fisher ER: The organ distribution of disseminated 5lCr-labeled tumor cells. Cancer Res 27:412-420, 1967
5. Ron At PM: The elution of 5lCr from labeled leuko cytes-a new theory. Blood 33:408-413, 1969
6. Vincent PC, Nicholes A: The fate of 5, Cr labeled Ehrlich ascites tumor cells. Aust J Exp Biol Med Sci 42:569-578, 1964.
7. Hoeer KG, Hughs WL: Evaluation of 51 Cr-chromatc for studying migration and death of tumor cells in vivo. Fed Proc 28:749, 1969
8. Huges WL, Commerford SL, Gitlin D, et al: Deoxyribonucleic acid metabolism in vivo: cell proliferation and death as measured by incorporation and elimination of iododeoxyuridine. Fed Proc 23: 640-649, 1964
9. Commerford SL: Biological stability of 5-iodo-2- deoxyuridine labeled with iodine 125 after its incorporation into the deoxyribonucleic acid of the mouse. Nature (London) 206:949-950, 1965
10. Feinendegen LE, Bond VP, Huges WL: 125I-DU (5-iodo-2-deoxyuridine) in autoradiographic studies of cell proliferation. Exp Cell Res 43:107-119, 1966
11. Fox BW, Prusoff WH: The comparative uptake of II2s-IabelIed 5-iodo-2-deoxyuridine and thymidine 3H into the tissues of mice bearing Hepatoma 129. Cancer Res 25:234-240, 1965
12. Cheong L, Rich MA, Eidinoff ML: Introduction of the 5-halogenated uracil moiety into deoxyribonucleic acid of mammalian cells in culture. J Biol Chem 235:1441-1447, 1960
13. Dethlefsen LA: Incorporation of 125iodine labelled 5-iodo-2-deoxyuridine into the DNA of mouse mammary tumors. In Normal and Malignant Cell Growth (Fry RJM, Griem ML, Kirsten W, eds.). New York, Springer-Verlag 1969, 186
14. Dethlefsen LA: Comparison of tumor radioactivity after the administration of either 125I or 3H labelled 5-iodo-2'-deoxyuridine. Cancer Res 29:1717-1720, 1969
15. Eidinoff ML, Cheong L, Rich MA: Incorporation of unnatural pyrimidine bases into deoxyribonucleic acid of mammalian cells. Science 129:1550-1551, 1959
16. Gambetta Hampton E, Rich MA, Eidinoff ML: Introduction of the 5-iodouracil moiety into deoxyribonucleic acid of mammalian cells. J Biol Chem 235:3562-3566, 1960
17. Hofer KG, Prensky W, Huges WL: The measure ment of tumor cell death in vivo with iodine 125 labelled iododeoxy uridine. J Cell Biol 39:62, 1968
18. Hofer KG, Rosenoff S, Prensky W et al: Spon taneous and amethopterin induced death of L 1210 leukemia cells in vivo. Nature (London) 221:576577, 1969
19. Hofer KG, Prensky W, Huges WL: Death and metastatic distribution of tumor cells in mice monitored with 125I-iododeoxyuridine. J Nat Cancer Inst 43:763-773, 1969
20. Mak S, Till JE: Use of I125 labelled 5-iodo-2-deoxy-uridine for the measurement of DNA synthesis in mammalian cells in vitro. Canad J Biochem (Ottawa) 41:2343-2351, 1963
21. Morris NR, Cramer JW: DNA synthesis by mammalian cells inhibited in culture by 5-iodo-2-deoxy- uridine. Mol Pharm 2:1-9, 1966
22. Morris NR, Cramer JW: 5-Iodo-2-deoxyuridine and DNA synthesis in mammalian cells. Exp Cell Res 51:555-563, 1968
23. Prusoff WH: Synthesis and biological activity of iododeoxyuridine, an analogue of thymidine. Biochem Biophys Acta 32:295-296, 1959
24. Hanawalt PC, Maaloe O, Cummings DJ: The normal DNA replication cycle. II. J Molec Biol 3:156-165, 1961
25. Zamenhof S, DeGiovanni R, Rich K: Escherichia coli containing unnatural pyrimidines in its deoxyribonucleic acid. J Bact 71:60-69, 1956
26. Kopriwa BM, Lebland CP: Improvements in the coating technique of radioautography. J Histochem Cytochem 10:269-284, 1962
27. Bryant BJ, Cole LJ: Evidence for pluropotentiality of marrow stem cells: Modification of tissue distribution of in vivo 1251-Udr labelled transplanted marrow. In The Lymphocyte in Immunology and Haemopoiesis. London, Edward Arnold Ltd., 1967
28. Hinrichs HR, Petersen RO, Baserga R: Incorpo ration of thymidine into DNA of mouse organs. Arch Path (Chicago) 78:245-253, 1964
29. Scott JF, Fraggastoro AP, Taft EB: Studies in histochemistry. I. Determination of nucleic acids in microamounts of tissue. J Histochem Cytochem 4:1-10, 1956
30. Zeidman I, McCutcheon M, Coman DR: Factors affecting the number of tumor metastases; experiments with a transplantable mouse tumor. Cancer Res 10:357-359, 1950
31. Wood S Jr: Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber. Arch Path 66:550-568, 1958
32. Zeidman I: The fate of circulating tumor cells. I. Passage of cells through capillaries. Cancer Res 21:38-39, 1961
33. Zeidman I, Buss JM: Transpulmonary passage of tumor cell emboli. Cancer Res 12:731-733, 1952
34. Zeidman I, Gamble WJ, Clovis WL: Immediate passage of tumor cell emboli through the liver and kidney. Cancer Res 16:814-815, 1956
35. Nadel EM, ed: Symposium on tumor cells in peripheral blood. Acta Cytol 9:3, 1965
36. Fisher B, Fisher ER: Transmigration of lymph nodes by tumor cells. Science 152:1397-1398, 1966
37. Announcement: A cautionary note to those concerned with circulating cancer cells in the blood. J Nat Cancer Inst 28:1023-1024, 1962
38. Joansson O: The viability of circulating tumor cells in experimental cancer. Surg Forum 9:577-580, 1958
39. Romsdahl MD, Chu EW, Hume R: The time of metastasis and release of tumor cells as determined in an experimental system. Cancer 14:883-888, 1961
40. Goldie H, Jeffries BR, Jones AM: Detection of metastatic tumor cells by intraperitoneal inoculation of organ brei from tumor-bearing mice. Cancer Res 13:566-573, 1953
41. Wexler H, Ryan JJ, Ketcham AS: The study of cir culating tumor cells by the formation of pulmonary embolic tumor growths in a secondary host. Cancer 23:946-951, 1969
42. Mendelsohn ML, Dethlefsen LA: Tumor growth