Autoradiographic localization of neurotransmitter binding sites in the hypoglossal and motor trigeminal nuclei of the rat

Synapse

Volumn 28, Issue 1, 1998, Pages 44-59

  Manaker, Scott ^a   Zucchi, Paola C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5HT (5 hydroxytryptamine, serotonin); Motoneuron; Substance P; Thyrotropin releasing hormone

Indexed keywords

NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; PROTIRELIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SUBSTANCE P; NEUROKININ 1 RECEPTOR; PROTIRELIN RECEPTOR; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; HYPOGLOSSAL NUCLEUS; HYPOTHALAMUS NUCLEUS; LIGAND BINDING; MALE; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY; THALAMUS VENTRAL NUCLEUS; TRIGEMINAL NUCLEUS; ANIMAL; HYPOGLOSSAL NERVE; ISOLATION AND PURIFICATION; METABOLISM; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; AUTORADIOGRAPHY; BINDING SITES; HYPOGLOSSAL NERVE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, THYROTROPIN-RELEASING HORMONE; SUBSTANCE P; TRIGEMINAL NUCLEI;

EID: 0013634051     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199801)28:1<44::AID-SYN6>3.0.CO;2-C     Document Type: Article

References (82)

1. Aldes, L.D. (1990) Topographically organized projections from the nucleus subceruleus to the hypoglossal nucleus in the rat: a light and electron microscopic study with complementary axonal transport techniques. J. Comp. Neurol., 302:643-656.
2. Aldes, L.D., and Boone, T.B. (1985) Organization of projections from the principal sensory trigeminal nucleus to the hypoglossal nucleus to be hypoglossal nucleus in the rat: an experimental light and electron microscopic study with axonal tracer techniques. Exp. Brain Res., 59:16-29.
3. Aldes, L.D., Chronister, R.B., Marco, L.A., Haycock, J.W., and Thibault, J. (1988) Differential distribution of biogenic amines in the hypoglossal nucleus of the rat. Exp. Brain Res., 73:305-314.
4. Aldes, L.D., Chapman, M.E., Chronister, R.B., and Haycock, J.W. (1992) Sources of nonadrenergic afferents to the hypoglossal nucleus in the rat. Brain Res., 29:931-942.
5. Alexander, G.M., Schwartzman, R.J., Bel, R.D., Yu, J., and Renthal, A. (1981) Quantitative measurement of local cerebral metabolic rate for glucose using tritiated 2-deoxyglucose. Brain Res., 223:59-67.
6. Altschuler, S.M., Bao, X., and Miselis, R.R. (1994) Dendritic architecture of hypoglossal motoneurons projecting to extrinsic tongue musculature in the rat. J. Comp. Neurol., 342:538-550.
7. Basbaum, A.I., Clanton, C.H., and Fields, H.L. (1978) Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J. Comp. Neurol., 178:209-224.
8. Bayliss, D.A., Viana, F., and Berger, A.J. (1992) Mechanisms underlying excitatory effects of thyrotropin-releasing hormone on rat hypoglossal motoneurons in vitro. J. Neurophysiol., 68:1733-1745.
9. Bayliss, D.A., Viana, F., and Berger, A.J. (1993) Thyrotropin-releasing hormone causes excitation of rat hypoglossal motoneurons in vitro. Sleep, 16:S49-S52.
10. Bayliss, D.A., Viana, F., Kanter, R.K., Szymeczek-Seay, C.L., Berger, A.J., and Millhorn, D.E. (1994) Early postnatal development of thyrotropin-releasing hormone (TRH) expression, TRH receptor binding, and TRH responses in neurons of rat brainstem. J. Neurosci., 14:821-833.
11. Bayliss, D.A., Umemiya, M., and Berger, A.J. (1995) Inhibition of N- and P-type calcium currents and the after-hyperpolarization in rat motoneurones by serotonin. J. Physiol., 485:635-647.
12. Berger, A.J., Bayliss, D.A., and Viana, F. (1992) Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. Neurosci. Lett., 143:164-168.
13. Borke, R.C., and Nau, M.E. (1985) The ultrastructural identification of reticulo-hypoglossal axon terminals anterogradely labeled with horseradish perioxidase. Brain Res., 337:127-132.
14. Borke, R.C., and Nau, M.E. (1987) The ultrastructural morphology and distribution of trigemino-hypoglossal connections labeled with horseradish perioxidase. Brain Res., 422:235-241.
15. Borke, R.C., Nau, M.E., and Ringler, Jr, R.L. (1983) Brain stem afferents of hypoglossal neurons in the rat. Brain Res., 269:47-55.
16. Borke, R.C., Nau, M.E., and Newman, D.B. (1988) Reticulo- and trigemino-hypoglossal connections: a quantitative comparison of ultrastructural substrates. Brain Res. Bull., 21:795-803.
17. Card, J.P, Riley, J.N., and Moore, R.Y. (1986) The motor trigeminal nucleus of the rat: analysis of neuronal structure and the synaptic organization of noradrenergic afferents. J. Comp. Neurol., 250:469-484.
18. Connaughton, M., Priestley, J.V., Sofroniew, M.V., Eckenstein, F., and Cuello, A.C. (1986) Inputs to motoneurones in the hypoglossal nucleus of the rat: light and electron microscopic immunocytochemistry for choline acetyltransferase, substance P and enkephalins using monoclonal antibodies. Neuroscience, 17:205-224.
19. Cropper, E.C., Eisenman, J.S., and Azmitia, B.C. (1984) 5-HT-immunoreactive fibers in the trigeminal nuclear complex of the rat. Exp. Brain Res., 55:515-522.
20. Eskay, R.L., Long, R.T., and Palkovits, M. (1983) Localization of immunoreactive thyrotropin releasing hormone in the lower brain-stem of the rat. Brain Res., 277:159-162.
21. Fort, P., Luppi, P-H., Sakai, K., Salvert, D., and Jouvet, M. (1990) Nuclei of origin of monoaminergic peptidergic, and cholinergic afferents to the cat trigeminal motor nucleus: a double-labeling study with cholera-toxin as a retrograde tracer. J. Comp. Neurol., 301:262-275.
22. Funk, G.D., Smith, J.C., and Feldman, J.L. (1994) Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro. J. Neurophysiol., 72:2538-2541.
23. Geary, W.A., Toga, A.W., and Woolen, G.F. (1985) Quantitative film autoradiography for tritium: methodological considerations. Brain Res., 337:99-108.
24. Hendricks, J.C., Kovalski, R.J., and Kline, L.R. (1991) Phasic respiratory muscle patterns and sleep-disordered breathing during rapid eye movement sleep in bulldogs. Am. Rev. Respir. Dis., 144:1112-1120.
25. Herkenham, M., and Sokoloff, L. (1984) Quantitative receptor autoradiography: tissue defatting eliminates differential self-absorption of tritium radiation in grey and white matter. Brain Res., 321:363-368.
26. Holstege, G., Kuypers, H.G.J.M., and Dekker, J.J. (1977) The organization of the bulbar fibre connections to the trigeminal, facial and hypoglossal motor nuclei. II. Brain, 100:265-286.
27. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxene, P.R., and Humphrey, P.P.A. (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46:157-203.
28. Jackson, D.A., and White, S.R. (1990) Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology, 29:787-797.
29. Jiang, C., Mitchell, G.S., and Lipski, J. (1991) Prolonged augmentation of respiratory discharge in hypoglossal motoneurons following superior laryngeal nerve stimulation. Brain Res., 538:215-225.
30. Johansson, O., Hökfelt, T., Pernow, B., Jeffcoate, S.L., White, N., Steinbusch, H.W.M., Verhofstad, A.A.J., Emson, P.C., and Spindel, E. (1981) Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine-, substance P- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord. Neuroscience, 6:1857-1881.
31. Katakura, N., and Chandler, S.H. (1990) An iontophoretic analysis of the pharmacologic mechanisms responsible for trigeminal motoneuronal discharge during masticatory-line activity in the guinea pig. J. Neurophysiol., 63:356-369.
32. Kitamura, S., Nishiguchi, T., and Sakai, A. (1983) Location of cell somata and the peripheral course of axons of the geniohyoid and thyrohyoid motoneurons: a horseradish peroidase study in the rat. Exp. Neurol., 79:87-96.
33. Kitamura, S., Nishiguchi, T., and Sakai, A. (1985) A horseradish peroxidase study of rat lingual motoneurons with axons passing through the cervical nerve. Exp. Neurol., 87:20-34.
34. Krammer, E.B., Rath, T., and Lischka, M.F. (1979) Somatotopic organization of the hypoglossal nucleus: an HRP study in the rat. Brain Res., 170:533-537.
35. Kubin, L., Tojima, H., Davies, R.O., and Pack, A.I. (1992) Serotoninergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci. Lett., 139:243-248.
36. Kubin, L., Reignier, C., Tojima, H., Taguchi, O., Pack, A.I., and Davies, R.O. (1994) Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia. Brain Res., 645:291-302.
37. Kuhar, M.J., and Unnerstall, J.R. (1982) In vitro labeling receptor autoradiography: loss of label during ethanol dehydration and preparative procedures. Brain Res., 244:178-181.
38. Li, Y.-Q., Takada, M., and Mizuno, N. (1993) The sites of origin of serotonergic afferent fibers in the trigeminal motor, facial, and hypoglossal nuclei in the rat. Neurosci. Res., 17:307-313.
39. 14C-compounds. Brain Res., 459:105-119.
40. Lingenhöhl, K., and Friauf, E. (1991) Sensory neurons and motoneurons of the jaw-closing reflex pathway in rats: a combined morphological and physiological study using the intracellular horseradish peroxidase technique. Exp. Brain Res., 83:385-396.
41. Lovick, T.A., and Robinson, J.P. (1983) Bulbar raphe neurones with projections to the trigeminal nucleus and the lumbar cord in the rat: a fluorescence double-labelling study. Exp. Brain Res., 50:299-344.
42. Lowe, A.A. (1981) The neural regulation of tongue movements. Prog. Neurobiol., 15:295-344.
43. Lydic, R. (1988) Central regulation of sleep and anatomic physiology. In: Clinical Physiology of Sleep. R. Lydic and J.F. Biebuyck, eds. American Physiological Society, Waverly Press, Baltimore, pp. 1-19.
44. Lynn, R.B., Kreider, M.S., and Miselis, R.R. (1991) Thyrotropin-releasing hormone-immunoreactive projections to the dorsal motor nucleus and the nucleus of the solitary tract of the rat. J. Comp. Neurol., 311:271-288.
45. Maeno, H., Kiyama, H., and Tohyama, M. (1993) Distribution of the substance P receptor (NK-1 receptor) in the central nervous system. Mol. Brain Res., 18:43-58.
46. Manaker, S., and Henry, J.N. (1994) Colocalization of substance P in serotonergic afferents to the hypoglossal nucleus. Neurosci. Abst., 20:1587.
47. Manaker, S., and Rizio, G. (1989) Autoradiographic localization of thyrotropin-releasing hormone and substance-P receptors in the rat dorsal vagal complex. J. Comp. Neurol., 290:516-526.
48. Manaker, S., and Tischler, L.J. (1993) Origin of serotonergic afferents to the hypoglossal nucleus in the rat. J. Comp. Neurol., 334:466-476.
49. Manaker, S., and Verderame, H.M. (1990) Organization of serotonin 1A and 1B receptors in the nucleus of the solitary tract. J. Comp. Neurol., 301:535-553.
50. Manaker, S., Winokur, A., Rostene, W.H., and Rainbow, T.C. (1985) Autoradiographic localization of thyrotropin-releasing hormone (TRH) receptors in the rat central nervous system. J. Neurosci., 5:167-174.
51. Manaker, S., Tischler, L.J., and Morrison, A.R. (1992) Raphespinal and reticulospinal axon collaterals to the hypoglossal nucleus in the rat. J. Comp. Neurol., 322:68-78.
52. Nakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S., and Mizuno, N. (1994) Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J. Comp. Neurol., 347:249-274.
53. Odutola, A.B. (1976) Cell grouping and Golgi architecture of the hypoglossal nucleus of the rat. Exp. Neurol., 52:356-371.
54. Palkovits, M., Mezey, E., Eskay, R.L., and Brownstein, M.J. (1986) Innervation of the nucleus of the solitary tract and the dorsal vagal nucleus by thyrotropin-releasing hormone-containing raphe neurons. Brain Res., 373:246-251.
55. Pazos, A., and Palacios, J.M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-1 receptors. Brain Res., 346:203-230.
56. Pazos, A., Cortes, R., and Palacios, J.M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res., 346:231-249.
57. Pilowsky, P., Sun, Q.-J., Minson, J.B., Amolda, L.F., Chalmers, J.P., and Llewellyn-Smith, I.J. (1994) Thyrotropin-releasing hormone inputs to brainstem respiratory neurons. Neurosci. Abst., 20:545.
58. Poulat, P., Marlier, L., Rajaofetra, N., and Privat, A. (1992) 5-hydroxytryptamine, substance P and thyrotropin-releasing hormone synapses in the intermediolateral cell column of the rat thoracic spinal cord. Neurosci. Lett., 136:19-22.
59. Rainbow, T.C., Bleisch, W.V., Biegon, A., and MacEwen, B.S. (1982) Quantitative densitometry of neurotransmitter receptors. J. Neurosci. Methods, 6:127-138.
60. Rekling, J.C. (1990) Excitatory effects of thyrotropin-releasing hormone (TRH) in hypoglossal motoneurones. Brain Res., 510:175-179.
61. Rekling, J.C. (1992) Interaction between thyrotropin-releasing hormone (TRH) and NMDA-receptor-mediated responses in hypoglossal motoneurones. Brain Res., 578:289-296.
62. Ribeiro-do-Valle, L.E., Metzler, C.W., and Jacobs, B.L. (1991) Facilitation of masseter EMG and masseteric (jaw-closure) reflex by serotonin in behaving cats. Brain Res., 550:197-204.
63. Saha, S., Appenteng, K., and Batten, T.F.C. (1991) Light and electron microscopical localisation of 5-HT-immunoreactive boutons in the rat trigeminal motor nucleus. Brain Res., 559:145-148.
64. Shults, C.W., Quirion, R., Chronwall, B., Chase, T.N., and O'Donahue, TL. (1984) A comparison of the anatomical distribution of substance P and substance P receptors in the rat central nervous system. Peptides, 5:1097-1128.
65. Staines, W.A., Meister, B., Melander, T., Nagy, J.I., and Hokfelt, T. (1988) Three-color immunofluorescence histochemistry allowing triple labeling within a single section. J. Histochem. Cytochem., 36:145-151.
66. Takada, M., Itoh, K., Yasui, Y., Mitani, A., Nomura, S., and Mizuno, N. (1984) Distribution of premotor neurons for the hypoglossal nucleus in the cat. Neurosci. Lett., 52:141-146.
67. Takahashi, T., and Berger, A.J. (1990) Direct excitation of rat spinal motoneurones by serotonin. J. Physiol., 423:63-76.
68. Takeuchi, Y., Kojima, M., Matsuura, T., and Sano, Y. (1983) Serotonergic innervation on the motoneurons in the mammalian brainstem. Light and electron microscopic immunohistochemistry. Anat. Embryol., 167:321-333.
69. Tallaksen-Greene, S.J., Eide, R., and Wessendorf, M.W. (1993) Regional distribution of serotonin and substance P co-existing in nerve fibers and terminals in the brainstem of the rat. Neuroscience, 53:1127-1142.
70. Travers, J.B. (1995) Oromotor nuclei. In: The Rat Nervous System (2nd ed.). G. Paxinos, ed. Academic Press, San Diego, CA, pp. 239-255.
71. Travers, J.B., and Norgren, R. (1983) Afferent projections to the oral motor nuclei in the rat. J. Comp. Neurol., 220:280-298.
72. Ugulini, G., Kuypers, H.G.J.M., and Simmons, A. (1987) Retrograde transneuronal transfer of Herpes simplex virus type I (HSV 1) from motoneurons. Brain Res., 422:242-256.
73. Ulfhake, B., Arvidsson, U., Cullheim, S., Hökfelt, T., Brodin, E., Verhofstad, A., and Visser, T. (1987) An ultrastructural study of 5-hydroxytryptamine-, thyrotropin-releasing hormone- and substance P-immunoreactive axonal boutons in the motor nucleus of spinal cord segments L7-S1 in the adult cat. Neuroscience, 23:917-929.
74. 3H]ultrofilm: application to multiple benzodiazepine receptors. J. Neurosci. Methods, 6:59-73.
75. Wan, X.S.T., Trojanowski, J.Q., Gonatas, J.O., and Liu, C.N. (1982) Cytoarchitecture of the extranuclear and commissural dendrites of hypoglossal nucleus neurons as revealed by conjugates of horseradish perioxidase with cholera toxin. Exp. Neurol., 78:167-175.
76. Wang, M.Y., and Dun, N.J. (1990) 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. J. Physiol., 430:87-103.
77. White, S.R., Crane, G.J., and Jackson, D.A. (1989) Thyrotropin-releasing hormone (TRH) effects on spinal cord neuronal excitability. Ann. N.Y. Acad. Sci., 553:337-350.
78. White, S.R., Fung, S.J., Jackson, D.A., and Imel, K.M. (in press) Serotonin, norepinephrine and associated neuropeptides: effects on somatic motoneuron excitability. Prog. Brain Res., 107:183-199, 1996.
79. Winer, B.J. (1971) Statistical Principles in Experimental Design., McGraw-Hill, New York.
80. 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol., 351:357-373.
81. 1 receptors attenuates synaptic transmission to immature rat motoneurones in vitro. Brain Res., 554:111-121.
82. Zabavnik, J., Arbuthnott, G., and Eidne, K.A. (1993) Distribution of thyrotropin-releasing hormone receptor messenger RNA in rat pituitary and brain. Neuroscience, 53:877-887.