Process Characterization Studies to Facilitate Validation of a Recombinant Protein Fermentation

ACS Symposium Series

Volumn 698, Issue , 1998, Pages 12-27

  Zhang, Jinyou ^a   Reddy, Jay ^a   Salmon, Peter ^a   Buckland, Barry ^a   Greasham, Randy ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0013542591     PISSN: 00976156     EISSN: None     Source Type: Book Series    
DOI: 10.1021/bk-1998-0698.ch002     Document Type: Article

References (4)

1. FDA. Guidelines of general principles of process validation. 1987.
2. Fu, J.; Vandusen, W. J.; Kolodin, D. G., O'Keefe, D. O.; Herber, W. K.; George, H. A. Continuous culture study of the expression of hepatitis B surface antigen and its self-assembly into virus-like particles in Saccharomyces cerevisiae. Biotechnol. Bioeng. 1996, 49: 578-586.
3. Oura, E. Effect of aeration intensity on the biochemical composition of baker's yeast. I. Factors affecting the type of metabolism. Biotechnol. Bioeng. 1974, 16: 1197-1212.
4. Pirt, S. J. Principles of microbe and cell cultivation. Blackwell Scientific Publications, Inc.: Palo Alto, CA, 1975; Chapter 19, pp 196-198.