Neoplastic stroma and epithelium show up-regulation of platelet-derived endothelial cell growth factor/thymidine phosphorylase in colorectal carcinomas but not adenomas

Angiogenesis

Volumn 2, Issue 1, 1998, Pages 49-55

  Kaklamanis, Loukas ^a,b   Kakolyris, Stelios ^a   Turley, Helen ^c   Koukourakis, Michael ^c   Biddolph, Simon ^a   Gatter, Kevin C ^a   Harris, Adrian L ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Adenoma; Carcinoma; Colorectal cancer; Macrophage; Thymidine phosphorylase

Indexed keywords

EID: 0013542251     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009002426554     Document Type: Article

References (23)

1. Blood CH, Zetter BR. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1990; 1032, 89-118.
2. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82, 4-6.
3. Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes Memorial Award Lecture. Cancer Res 1986; 46, 467-473.
4. Bicknell R, Harris AL. Novel growth regulatory factors and tumour angiogenesis. Eur J Cancer 1991; 27, 781-785.
5. Ishikawa F, Miyazono K, Hellman U, et al. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature, 1989; 338, 557-562.
6. Moghaddam A, Zhang H-T, Fan T-P, et al. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA 1995; 92, 998-1002.
7. Moghaddam A, Bicknell R. Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry 1992; 31, 12141-12146.
8. Usuki K, Saras J, Waltenberger J, et al. Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem Biophys Res Commun 1992; 184, 1311-1316.
9. Barton GJ, Ponting CP, Spraggon G, Finnis C, Sleep D. Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase. Protein Sci 1992; 1, 688-690.
10. Finnis C, Dodsworth N, Pollitt CE, Carr G, Sleep D. Thymidine phosphorylase activity of platelet-derived endothelial cell growth factor is responsible for endothelial cell mitogenicity. Eur J Biochem 1993; 212, 201-210.
11. Haraguchi M, Kazutaka M, Uemura K, et al. Angiogenic activity of enzymes. Nature 1994; 368, 198.
12. Reynolds K, Farzaneh F, Collins WP, et al. Correlation of ovarian malignancy with expression of platelet-derived endothelial cell growth factor. J Natl Cancer Inst 1994; 86, 1234-1238.
13. Vertongen F, Fondu P, Van Den Heule B, Cauchie C, Mandelbaum IM. Thymidine kinase and thymidine phosphorylase activities in various types of leukemia and lymphoma. Tumour Biol 1984; 5, 303-311.
14. Yoshimura A, Kuwazuru Y, Furukawa T, Yoshida H, Yamada K, Akiyama S. Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors. Biochim Biophys Acta 1990; 1034, 107-113.
15. Kono A, Hara Y, Sugata S, Matsusima Y, Ueda T. Substrate specificity of a thymidine phosphorylase in human liver tumor. Chem Pharm Bull 1984; 32, 1919-1921.
16. Fox SB, Moghaddam A, Westwood M, et al. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. J Pathol 1995; 176, 183-190.
17. Fox SB, Westwood M, Moghaddam A, et al. The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium. Br J Cancer 1996; 73, 275-280.
18. Mason DY, Cordell JL, Pulford KAF. Production of monoclonal antibodies for immunocytochemical use. Techniques Immunocytochem 1983; 2, 175.
19. Takebayashi Y, Akiyama S, Akiba S, et al. Clinico-pathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase in human colorectal carcinoma. J Natl Cancer Inst 1996; 88, 1110-1117.
20. Takahashi Y, Bucana CD, Liu W, et al. Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells. J Natl Cancer Inst 1996; 88, 1146-1151.
21. Polverini PJ, Leibovich SJ. Induction of neo-vascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. Lab Invest 1984; 51, 635-642.
22. Eda H, Fujimoto K, Wanatabe S, et al. Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine. Cancer Chemother Pharmacol 1993; 32, 333-338.
23. Patterson A, Zhang H, Moghaddam A, et al. Increased sensitivity to the pro-drug 5′-deoxy-5-fluorouridine and modulation of 5′-fluoro-5-deoxyuridine sensitivity in MCF-7 cell transfected with thymidine phosphorylase. Br J Cancer 1995; 72, 669-675.