Evidence-Based Data from Animal and Human Experimental Studies on Pain Relief with Antidepressants: A Structured Review

Pain Medicine

Volumn 1, Issue 4, 2000, Pages 310-316

  Fishbain, David A ^a,b   Cutler, Robert ^a,b   Rosomoff, Hubert L ^a,b   Rosomoff, Renee Steele ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

Animal Pain Models; Antidepressants; Antinociception; Antinociceptive Effect; Chronic Pain; Serotonergic; Serotonergic Noradrenergic; Structured Review

Indexed keywords

EID: 0013343983     PISSN: 15262375     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-4637.2000.00042.x     Document Type: Article

References (60)

1. Getto CJ, Sorkness CA, Howell T. Antidepressants and chronic nonmalignant pain: a review. J Pain Symptom Manage 1987;2:9-18.
2. Orsulak PJ, Waller D. Antidepressant drugs: additional clinical uses. J Fam Pract 1989; 28:209-16.
3. Egbunike IG, Chaffee BJ. Antidepressants in the management of chronic pain syndromes. Pharmacotherapy 1990;10:262-70.
4. France RD. The future for antidepressants: treatment of pain. Psychopathology 1987;20 (1 suppl):99-113.
5. France RD, Houpt JL, Ellinwood EH. Therapeutic effects of antidepressants in chronic pain. Gen Hosp Psychiatry 1984;6:55-63.
6. Goodkin K, Gullion CM. Antidepressants for the relief of chronic pain: do they work? Ann Behav Med 1989;11:83-101.
7. Turner JA, Denny MC. Do antidepressant medications relieve chronic low back pain. J Fam Pract 1993;37:545-53.
8. McQuay HJ, Moore RA, Eccleston C, Morley S, Williams AC. Systematic review of outpatient services for chronic pain control. [Review], Health Tech Assess 1997;1:1-135.
9. Ongena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain 1992;49:205-19.
10. Fishbain DA, Cutler RB, Rosomoff HL, Rosomoff RS. Do antidepressants have an analgesic effect in psychogenic pain and somatoform pain disorder: a meta-analysis. J Psychosom Med 1998;60:503-9.
11. Philipp M, Fickinger M. Psychotropic drugs in the management of chronic pain syndromes. Pharmacopsychiat 1993;26:221-34.
12. Goodkin K, Vrancken MAE, Feaser D. On the putative efficacy of the antidepressants in chronic, benign pain sydromes, an update. Pain Forum 1995;4:237-47.
13. Max MB. Thirteen consecutive well-designed randomized trials show that antidepressants reduce pain in diabetic neuropathy and postherpetic neuralgia. Pain Forum 1995;4:248-53.
14. Teasell RW, Merskey H, Deshpande S. Antidepressants in rehabilitation. Rehab Pharmacother 1999; 10:237-53.
15. McQuay HJ, Tramer M, Nye BA, Carroll D, Wiffen PJ, Moore RA. A systematic review of antidepressants in neuropathic pain. Pain 1996;68:217-27.
16. Fishbain, DA. Evidence based data on pain relief with antidepressants. Ann Med 2000;32:305-16.
17. Max MB, Culnane M, Schafer SC, et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987;37:589-96.
18. Max MB, Kishore-Kumar R, Schafer SC, et al. Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial. Pain 1991;45:3-9.
19. Max MB, Lynche SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326:1250-6.
20. Watson CPN, Chipman M, Reed K, Evans RJ, Birkett N. Amitriptyline versus maprotiline in post-herpetic neuralgia: a randomized, double blind, cross-over trial. Pain 1992;48:29-36.
21. Sindrup SH, Grodum E, Gram LF, Beck-Nielsen H. Concentration-response relationship in paroxetine treatment of diabetic neuropathy symptoms: a patient-blinded dose escalation study. Ther Drug Monit 1991;13:408-14.
22. Sindrup SH, Gram LF, Boosen K, Eshoj O, Mogensen EF. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 1990;42:135-44.
23. Yaksh TL, Al-Rodhan NRF, Jensen TS. Sites of action of opiates in production of analgesia. Prog Brain Res 1988;77:371-94.
24. Max MB. Antidepressants as analgesics. In: Fields HL, Liebeskind JC, eds. Progress in Pain Research and Management. Seattle: IASP Press; 1994:229-46.
25. de Felipe MC, de Ceballos ML, Fuentes JA. Hypalgesia induced by antidepressants in mice: a case for opioids and serotonin. Euro J Pharmac 1986;124:193-9.
26. Ventafridda V, Bianchi M, Ripamonti C, et al. Studies on the effects of antidepressant drugs on the anti-nociceptive action of morphine and on plasma morphine in rat and man. Pain 1990;43:155-62.
27. Spiegel K, Kalb R, Pasternak GW. Analgesic activity of trycyclic antidepressants. Ann Neurol 1983;13:462-5.
28. Sawynok J, Esser MJ, Reid AR. Peripheral antinociceptive actions of desipramine and fluoextine in an inflammatory and neuropathic pain test in the rat. Pain 1999;28:149-58.
29. Testa R, Angelico P, Abbiati GA. Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats. Pain 1987;29:247-55.
30. Ardid D, Guilbaud G. Antinociceptive effects of acute and 'chronic' injections of tricyclic antidepressant drugs in a new model of mononeuropathy in rats. Pain 1992;49:270-87.
31. Esser MJ, Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain 1999;80:643-53.
32. Jacobson LO, Bleu K, Hunter JC, Lee C. Anti-thermal hyperalgesic properties of antidepressants in a rat model of neuropathic pain. American Pain Society Annual Meeting 1995;A95794:A105.
33. Su X, Gebhart GF. Effects of tricyclic antidepressants on mechanosensitive pelvic nerve afferent fibers innervating the rat colon. Pain 1998;76:105-14.
34. Ardid D, Eschalier A, Lavarenne J. Evidence for a central but not a peripheral analgesic effect of clomipramine in rats. Pain 1991;45:95-100.
35. Butler SH, Weil-Fugazza J, Godefroy F, Besson JM. Reduction of arthritic and pain behavior following chronic administration of amitriptyline or imipramine in rats with adjuvant induced arthritis. Pain 1985; 23:159-75.
36. Godefroy F, Butler SH, Weil Fugazza J, Besson JM. Do acute or chronic tricyclic antidepressants modify morphine antinociception in arthritic rats. Pain 1986; 25:233-44.
37. Seltzer Z, Tal M, Sharav Y. Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline. Pain 1989;37:245-50.
38. Abad F, Feria M, Boada J. Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats. Neurosc Ltrs 1989;99:187-90.
39. Reimann W, Schlutz H, Selve N. The antinociceptive effects of morphine, desipramine, and serotonin and their combinations after intrathecal injection in the rat. Anesth Analg 1999;88:141-5.
40. Rigal F, Eschalier A, Devoize JL, Pechadre JC. Activities of five antidepressants in a behavioral pain test in rats. Life Sci 1983;32:2965-71.
41. Bodnar RJ, Mann PE, Stone EA. Potentiation of cold-water swim analgesia by acute, but not chronic desipramine administration. Pharmac Biochem Behav 1985;23:749-52.
42. Hwang AS, Wilcox GL. Analgesic properties of intrathecally administered heterocyclic antidepressants. Pain 1987;28:343-55.
43. Jett MF, McGuirk J, Waligora D, Hunter JC. The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. Pain 1997; 69:161-9.
44. Sawynok J, Reid A. Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine. Pain 1992;50:113-8.
45. Rosland JH, Hunskaar S, Hole K. Modification of the antinociceptive effect of morphine by acute and chronic administration of clomipramine in mice. Pain 1988;33:349-55.
46. Hynes MD, Lochner MA, Bemis KG, Hymson DL. Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors. Life Sci 1985;36:2317-23.
47. Poulsen L, Arendt-Nielsen L, Brosen K, Nielsen KK, Gram LF, Sindrup SH. The hypoalgesic effect of imipramine in different human experimental pain models. Pain 1995;60:287-93.
48. Brom B, Meier W, Scharein E. Imipramine reduces experimental pain. Pain 1986;25:245-57.
49. Chapman CR, Butler SH. Effects of doxepin on perception of laboratory-induced pain in man. Pain 1978;5:253-62.
50. Peghini PL, Katz PO, Castell DO. Imipramine decreases oesophageal pain perception in human male volunteers. Gut 1998;42:807-13.
51. Gorelick AB, Koshy SS, Hooper FG, Bennett TC, Chey WD, Hasler WL. Differential effects of amitriptyline on perception of somatic and visceral stimulation in healthy humans. Am J Physiol 1998; 275(3 Pt 1):G460-6.
52. Langemark M, Loldrup D, Bech P, Olesen J. Clomipramine and Mianserin in the Treatment of Chronic Tension Headache. A Double-Blind, Controlled Study. Headache 1990;30:118-21.
53. Loldrup Poulsen D, Hansen HJ, Langemark M, Olesen J, Bech P. Discomfort or disability in patients with chronic pain syndrome. Psychother Psychosom 1987;48:60-2.
54. Frank RG, Kashani JH, Parker JC, et al. Antidepressant analgesia in rheumatoid arthritis. J Rheum 1988; 15:1632-8.
55. Rani PU, Naidu MUR, Prasad VBN, Rao TRK, Shobha JC. An evaluation of antidepressants in rheumatic pain conditions. Anesth Analg 1996;83:371-5.
56. Atkinson JH, Slater MA, Wahlgren DR, et al. Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity. Pain 1999; 83:137-45.
57. Bardin L, Lavarenne J, Eschalier A. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain 2000;86:11-8.
58. 4 agonists: BIMU 1 and BIMU 8. Life Sci 1996;58: 2297-309.
59. Dickerson K, Berlin JA. Meta-analysis: state-of-the-science. Epidemiol Rev 1992;14:154-76.
60. Spector TD, Thompson SG. The potential and limitations of meta-analysis. J Epidemiol Community Health 1991;45:89-92.