Transcriptional regulation of the vasopressin gene

Current Opinion in Endocrinology and Diabetes

Volumn 3, Issue 2, 1996, Pages 178-183

  Sherman, Thomas G ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0012938610     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199604000-00017     Document Type: Article

References (46)

1. Fitzsimmons MD, Roberts MM, Sherman TG, Robinson AG: Models of neurohypophyseal homeostasis. Am J Physiol 1992, 262:1121-1130.
2. Fitzsimmons MD, Roberts MM, Robinson AG: Control of posterior pituitary vasopressin content: Implications for the regulation of the vasopressin gene. Endocrinology 1994, 134:1874-1878. Models of physiologic systems have proven useful in identifying important components of many complex systems, from neural networks to three-dimensional protein structures, and they prove no less useful in the neurohypophysis. This study, and the paper by Fitzsimmons et al. (Am J Physiol 1992, 262:1121-1130) develop computer simulations of posterior pituitary depletion and repletion dynamics that identify transcriptional activity as the primary regulator of neurohypophyseal homeostasis.
3. Fitzsimmons MD, Roberts MM, Robinson AG: Control of posterior pituitary vasopressin content: Implications for the regulation of the vasopressin gene. Endocrinology 1994, 134:1874-1878. Models of physiologic systems have proven useful in identifying important components of many complex systems, from neural networks to three-dimensional protein structures, and they prove no less useful in the neurohypophysis. This study, and the paper by Fitzsimmons et al. (Am J Physiol 1992, 262:1121-1130) develop computer simulations of posterior pituitary depletion and repletion dynamics that identify transcriptional activity as the primary regulator of neurohypophyseal homeostasis.
4. Sherman TG, Day R, Civelli O, Douglass J, Herbert E, Akil H, Watson SJ: Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge. J Neurosci 1988, 8:3785-3796.
5. Verbalis JG, Drutarosky MD: Adaptation to chronic hypoosmolality in rats. Kidney Int 1988, 34:351-360.
6. Robinson AG, Roberts MM, Evron WA, Verbalis JG, Sherman TG: Hyponatremia in rats induces down regulation of vasopressin synthesis. J Clin Invest 1990, 86:1023-1029.
7. Verbalis JG: Osmotic inhibition of neurohypophysial secretion. Ann N Y Acad Sci 1993, 689:146-160.
8. Berghorn KA, Knapp LT, Hoffman GE, Sherman TG: Induction of glucocorticoid receptor expression in hypothalamic magnocellular vasopressin neurons during chronic hypoosmolality. Endocrinology 1995, 136:804-807. These authors describes a novel mechanism in the central nervous system and document the de novo induction of glucocorticoid receptor in hypothalamic magnocellular vasopressin neurons under conditions of hypoosmolality. The capability of physiology-specific steroid feedback control of vasopressin gene expression represents a high degree of plasticity that prompts a closer examination of other physiology-specific feedback circuits.
9. Knapp LT, Berghorn KA, Hoffman GE, Sherman TG: Osmolality-dependent steroid feedback regulation of vasopressin gene expression. In Neurohypophysis: Proceedings at the First Joint World Congress of Neurohypophysis and Vasopressin. Edited by Saito T, Kurokawa K, Yoshida S. Amsterdam: Elsevier; 1996:131-142.
10. Verbeeck MA, Mummery CL, Feijen A, Burbach JP: Survey of neuropeptide gene expression in tumor cell lines. Pathobiology 1992, 60:127-135.
11. Friedmann AS, Memoli VA, North WG: Vasopressin and oxytocin production by non-neuroendocrine lung carcinomas: an apparent low incidence of gene expression. Cancer Lett 1993, 75:79-85.
12. Verbeeck MA, Elands JP, de Leij LF, Buys CH, Carney DN, Bepler G, Roebroeck AJ, Van de Ven WJ, Burbach JP: Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines. Pathobiology 1992, 60:136-142.
13. Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K: Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone. Jpn J Cancer Res 1994, 85:718-722. The identification of vasopressin-expressing cell lines is sufficiently rare to be worth comment. The Lu-165 line described here is notable because it is the highest vasopressin-expressing cell line reported and may be valuable for general studies on vasopressin production as well as for specific studies on vasopressin expression in cancer cells.
14. Sausville E, Carney D, Battey J: The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. J Biol Chem 1985, 260:10236-10241.
15. Mohr E, Schmitz E, Richter D: A single rat genomic DNA fragment encodes both the oxytocin and vasopressin genes separated by 11 kilobases and oriented in opposite transcriptional directions. Biochimie 1988, 70:649-654.
16. Hara Y, Battey J, Gainer H: Structure of mouse vasopressin and oxytocin genes. Mol Brain Res 1990, 8:319-324.
17. Schmitz E, Mohr E, Richter D: Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE. DNA Cell Biol 1991, 10:81-91.
18. Mohr E, Bahnsen U, Kiessling C, Richter D: Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons. FEBS Lett 1988, 242:144-148.
19. Mezey E, Kiss JZ: Coexpresslon of vasopressin and oxytocin in hypothalamic supraoptic neurons of lactating rats. Endocrinology 1991, 129:1814-1820.
20. Zeng Q, Foo NC, Funkhouser JM, Carter DA, Murphy D: Expression of a rat vasopressin transgene in rat testes. J Reprod Fertil 1994, 102:471-481.
21. Murphy D, Ang HL, Zeng C, Ho MY, Funkhouser T, Carter D: Neuropeptide gene expression in transgenic animals. Prog Brain Res 1992, 92:77-96.
22. Wray S, Gainer H: Models for the study of cell-specific neuropeptide gene expression. Prog Brain Res 1992, 92:59-76.
23. Grant FD, Reventos J, Kawabata S, Miller M, Gordon JW, Majzoub JA: Transgenic mouse models of vasopressin expression. Hypertension 1993, 22:640-645.
24. Grant FD, Reventos J, Gordon JW, Kawabata S, Miller M, Majzoub JA: Expression of the rat arginine vasopressin gene in transgenic mice. Mol Endocrinol 1993, 7:659-667.
25. Grant FD, Reventos J, Gordon JW, Kawabata S, Miller M, Majzoub JA: Tissue-specific expression and osmotic regulation of a rat vasopressin gene in transgenic mice. Ann N Y Acad Sci 1993, 689:530-533.
26. Ang HL, Carter DA, Murphy D: Neuron-specific expression and physiological regulation of bovine vasopressin transgenes in mice. EMBO J 1993, 12:2397-12409.
27. Zeng Q, Carter DA, Murphy D: Cell specific expression of a vasopressin transgene in rats. J Neuroendocrinol 1994, 6:469-477. In the absence of reasonable cell lines for vasopressin in vitro studies, the transgenic animal approach represents the best model in which to explore physiologic-appropriate, tissue-specific, and transcriptional expression studies. To do so in rat transgenes makes use of the huge literature on vasopressin biochemistry, physiology, and molecular biology. The delimitation of the rat genomic sequences required for cell-specific and osmotically regulated vasopressin expression the in rat is a valuable advance.
28. Murphy D, Funkhouser J, Ang HL, Foo NC, Carter D: Extrahypothalamic expression of the vasopressin and oxytocin genes. Ann N Y Acad Sci 1993, 689:91-106.
29. Foo NC, Carter D, Murphy D, Ivell R: Vasopressin and oxytocin gene expression in rat testis. Endocrinology 1991, 128:2118-2128.
30. Ivell R, Hunt N, Hardy M, Nicholson H, Pickering B: Vasopressin biosynthesis in rodent Leydig cells. Mol Cell Endocrinol 1992, 89:59-66.
31. Lefebvre DL, Zingg HH: Novel vasopressin gene-related transcripts in rat testis. Mol Endocrinol 1991, 5:645-652.
32. Foo NC, Funkhouser JM, Carter DA, Murphy D: A testis-specific promoter in the rat vasopressin gene. J Biol Chem 1994, 269:659-667. A very complete and informative investigation into the identification and analysis of a testis-specific promoter and promoter sequence motif in the rat vasopressin gene. Now if we only understood the functional role for these nuclear transcripts.
33. Lipkin SM, Nelson CA, Glass CK, Rosenfeld MG: A negative retinoic response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains. Proc Natl Acad Sci U S A 1992, 89:1209-1213.
34. Adan RA, Cox JJ, Beischlag TV, Burbach JP: A composite hormone response element mediates the transactivation of the rat oxytocin gene by different classes of nuclear hormone receptors. Mol Endocrinol 1993, 7:47-57.
35. Pardy K, Adan PA, Carter DA, Seah V, Burbach JP, Murphy D: The identification of a cis-acting element involved in cyclic 3′,5′-adenosine monophosphate regulation of bovine vasopressin gene expression. J Biol Chem 1992, 267:21746-21752.
36. Comb M, Birnberg NC, Seasholtz A, Herbert E, Goodman HM: A cyclic AMP- and phorbol ester-inducible DNA element. Nature 1986, 323:353-356.
37. Adan R: Oxytocin and vasopressin genes: transcriptional regulation and signal transduction [PhD thesis]. Utrecht: Utrecht University; 1992.
38. Comb M, Mermod N, Hyman SE, Pearlberg J, Ross ME, Goodman H: Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J 1988, 7:3793-3806.
39. Glass CK, DiRenzo J, Kurokawa R, Han Z: Regulation of gene expression by retinoic acid receptors. DNA Cell Biol 1991, 10:623-638.
40. Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM: Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc Natl Acad Sci U S A 1992, 89:1448-1452.
41. Umesono K, Murakami KK, Thompson CC, Evans RM: Direct repeats a selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 1991, 65:1255-1266.
42. Adan RA, Burbach JP: Regulation of vasopressin and oxytocin gene expression by estrogen and thyroid hormone. Prog Brain Res 1992, 92:127-136.
43. Burbach JP, Adan RA, Cox JJ, da Silva SL: Transactivation of the rat oxytocin and vasopressin promoters by nuclear hormone receptors. Regul Pept 1993, 45:31-35.
44. Szot P, Dorsa DM: Expression of cytoplasmic and nuclear vasopressin RNA following castration and testosterone replacement: evidence for transcriptional regulation. Mol Cell Neurosci 1994, 5:1-10.
45. Wilson TE, Fahrner TJ, Johnton M, Milbrandt J: Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 1991, 252:1296-1300.
46. Chan RK, Brown ER, Ericsson A, Kovacs KJ, Sawchenko PE: A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J Neurosci 1993, 13:5126-5138.