Important recent advances in cardiovascular adrenergic mechanisms

Annual Review of Biomedical Sciences

Volumn 1, Issue , 1999, Pages 31-58

  Guimaraes S ^a,b  

^a Inst of Pharmacol and Therapeutics   (Portugal)

^b Institute of Pharmacology and Therapeutics   (Portugal)

Author keywords

Adrenoceptor subclassification; Catecholamine disposition; Cotransmission; Endothelium; Intracellular signaling; Maturation and ageing; Vascular physiology

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ALPHA 2D ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA 4 ADRENOCEPTOR; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; ENDOTHELIN; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROPEPTIDE Y; NORADRENALIN; PHOSPHOLIPASE C BETA1; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; AGING; BLOOD VESSEL; CARDIOVASCULAR ADRENERGIC MECHANISM; CATECHOLAMINE UPTAKE; CELL MEMBRANE; ENDOTHELIUM; ENZYME ACTIVATION; MATURATION; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENALIN RELEASE; PROTEIN TRANSPORT; REVIEW; SYMPATHETIC NERVE; VASCULAR DISEASE; VASCULAR TISSUE;

ANIMALIA;

EID: 0011341432     PISSN: 18068774     EISSN: 18068774     Source Type: Journal    
DOI: 10.5016/1806-8774.1999v1p31     Document Type: Review

References (173)

1. Ahlquist RF. A study of the adrenotropic receptors. Am J Physiol 1948;153:586-600.
2. 2-adrenoceptors. Br J Pharmacol 1986;88:607-15.
3. 4"-adrenoceptors. Pharmacol Toxicol 1998;83(suppl I):40-1.
4. Arch JRS, Kaumann AJ. Beta 3 and atypical beta-adrenoceptors. Med Res Rev 1993;13:663-729.
5. Asano T, Katada T, Gilman AG, Ross EM. Activation of the inhibitory protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles. J Biol Chem 1984;259:9351-4.
6. Barnes PJ. Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 1995;152:838-60.
7. Berthelsen S, Pettinger WA. A functional basis for classification of α-adrenergic receptors. Life Sci 1997;21:595-606.
8. Birnbaumer L. Receptor-to-effector signaling through G-proteins; roles for bg dimmers as well as a subunits. Cell 1992;71:1069-72.
9. Blaschko H, Born GVR, D'Iorio A, Eade ER. Observations on the distribution of catecholamines and adenosine triphosphate in the bovine adrenal medulla. J Physiol (Lond) 1956;133:548-57.
10. 1-adrenoceptors. Eur J Pharmacol. 1989;172:131-45
11. Borkowski KR, Gross R, Schneider H. Vascular β-adrenoceptor-mediated responses in hypertension and ageing rats. J Auton Pharmacol 1992;12:389-401.
12. Brock JA, Hardy TA, Dunn WR. Co-modulation of noradrenaline and ATP release at the vascular sympathetic neuroeffector junction. Pharmacol Toxicol 1998;83(suppl I):78-80.
13. Brodde O-E, Konschak U, Becker K, Rüter F, Poller U, Jakubetz J, Radke J. Cardiac muscarinic receptors decrease with age. J Clin Invest 1998;101:471-8.
14. Brodde O-E, Pönicke K. Age-dependent changes of human cardiac β-adrenoceptors. Pharmacol Toxicol 1998;83(suppl I):35-6.
15. Brown AM. Regulation of heartbeat by G protein-coupled ion channels. Am J Physiol 1990;259:H1621-H1628.
16. Brutsaert DL, Andries LJ. The endocardial endothelium. Am J Physiol 1992;263:S193-S196.
17. 2-adrenoceptors. Br J Clin Pharmacol 1986;21:721-2.
18. Bünemann M, Lee KB, Pals-Rylaarsdam R, Roseberry AG, Hosey MM. Desensitization of G-protein-coupled receptors in the cardiovascular system. Ann Rev Physiol 1999;61:169-92.
19. Burnstock G. Co-transmission. Arch Int Pharmacodyn 1990;304:7-33.
20. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz JR, Minneman KP, Molinoff PB, Ruffolo RR, Trendelenburg U. IV International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994;46:121-36.
21. 2B Adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one receptor subtype. J Pharmacol Exp Ther 1988;245:600-7.
22. Chaudry A, Mackenzie RG, Georgic LM, Granneman JG. Differential interaction of beta(1)-and beta (3)-adrenergic receptors with G (i) in rat adipocytes. Cellular Signalling 1994;6:457-65.
23. Chen XH, Harden TK, Nicholas RA. Molecular cloning and characterization of a novel beta-adrenergic receptor. J Biol Chem 1994;269:24810-9.
24. Conlon D, Johnston A, O'Malley K, Turner P, Kilfeather S. Effect of ageing and propranolol administration on myocardial β-adrenoceptor receptor function in mature rats. Eur J Pharmacol 1995;289:283-90.
25. 2-adrenoceptors. Br J Pharmacol 1990;101:285-90.
26. 1- adrenergic receptor. Proc Natl Acad Sci USA 1988;85:7159-63.
27. 2-adrenergic system of the platelet. Clin Sci 1987;73:507-13.
28. Docherty JR. Cardiovascular responses in ageing: a review. Pharmacol Rev 1990;42:103-25.
29. 2-adrenoceptors. Eur J Pharmacol 1998;361:1-15.
30. 2-adrenoceptor-mediated modulation in guinea-pig vas deferens. Naunyn-Schmiedeberg's Arch Pharmacol 1993;348:358-66.
31. 1-purinoceptor- mediated modulation of neural noradrenaline and ATP release in guinea-pig vas deferens. Naunyn-Schmiedeberg's Arch Pharmacol 1994;350:42-8.
32. Dubocovich ML, Langer SZ. Negative feedback regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre- and post-synaptic receptors. J Physiol (London) 1974;237:505-19.
33. Eisenhofer G. Plasma normetanephrine for examination of extraneuronal uptake and metabolism of noradrenaline in rats. Naunyn-Schmiedeberg's Arch Pharmacol 1994;349:259-69.
34. Eisenhofer G, Finberg JPM. Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther 1994;268:1242-51.
35. 2-adrenoceptors which modulate noradrenaline release in rabbits and rat occipital cortex Br J Pharmacol 1985;85:318P.
36. 1-Adrenoceptor subclassification in vascular smooth muscle. Trends Pharmacol Sci 1986;7:347-9.
37. Ford APDW, Chang DJ, Clarke DE, Daniels DV, Eglen RM, Gever JR, Jasper JR, Kava MS, Lachnit WG, Lesnick JD, Melov TD, Stepan GT, Williams TJ. Alpha-1A-versus alpha-1L-adrenoceptors: a pharmacological comparison. Pharmacol Toxicol 1998;83(suppl I):12-5.
38. 1- Adrenoceptor classification: sharpening Occam's razor. Trends Pharmacol Sci 1994;15:167-70.
39. Fouda A-K, Atkinson J. Sensitivity to noradrenaline and electrical stimulation decreases with age in the rat tail artery. Naunyn-Schmiedeberg's Arch Pharmacol 1986;344:37-9.
40. Freissmuth M, Waldhoer M, Bofill-Cardona E, Nanoff C. G protein antagonists. Trends Pharmacol Sci 1999;20:237-45.
41. 2 of yohimbine and phentolamine on the perfused rat heart under conditions of negligible autoinhibition. Br J Pharmacol 1983;79:109-19.
42. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
43. Gao Y, Tolsa JF, Botello M, Raj JU. Developmental change in isoproterenol-mediated relaxation of pulmonary veins of fetal and newborn lambs. J Appl Physiol 1998;84:1535-9.
44. Gauthier C, Tavernier G, Charpentier F, Langin D, Lemarec H. Functional beta (3)-adrenoceptor in the human heart. J Clin Invest 1996;98:556-62.
45. 2C-Adrenoceptors mediate contractile responses to noradrenaline in human saphenous vein. Naunyn-Schmiedeberg's Arch Pharmacol 1997;355:406-11.
46. Giannuzzi CE, Seidler FJ, Slotkin TA. Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes sensitization, not desensitization. Brain Res 1995;694:271-8.
47. Gonçalves J, Bültmann R, Driessen B. Opposite modulation of cotransmitter release in guinea-pig vas deferens: increase of noradrenalione release and decrease of ATP release by activation of prejunctional β-adrenoceptors. Naunyn-Schmiedeberg's Arch Pharmacol 1996;353:184-92.
48. Goodman OB, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, Benovic JL. β-Arrestin acts as a clathrin adaptor in endocytosis of the β-adrenergic receptor. Nature 1996;383:447-50.
49. 1-adrenoceptor. Eur J Pharmacol 1988;151:333-5.
50. 1 cells. J Biol Chem 1997;272:10408-13.
51. Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994;372:549-52.
52. Gründemann D, Schechinger B, Rappold GA, Schömig E. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nature Neurosci 1998;1:349-51.
53. Guimarães S, Brandão F, Paiva MQ. A study of the adrenoceptor-mediated feedback mechanisms by using adrenaline as a false transmitter. Naunyn-Schmiedeberg's Arch Pharmacol 1978;305:185-8.
54. a;358:207-11.
55. Guimarães S, Moura D. Advances in vascular neuroeffector mechanisms. Trends Pharmacol Sci 1999;20:90-3.
56. Guimarães S, Moura D, Paiva MQ, Vaz-da-Silva MJ. Lack of postjunctional beta adrenoceptor-mediated effects in the canine saphenous vein at birth. J Pharmacol Exp Ther 1994;268:990-5.
57. Guimarães S, Paiva MQ. The role played by the extraneuronal system in the disposition of noradrenaline and adrenaline in vessels. Naunyn-Schmiedeberg's Arch Pharmacol 1977;296:279-87.
58. b;124:1207-12.
59. Guimarães JT, Paiva MQ, Moura D, Guimarães S. Influence of maturation and ageing on the biotransformation of noradrenaline in the rat. J Neural Transm 1998;52(suppl):225-32.
60. Guimarães S, Paiva MQ, Moura D, Vaz-da-Silva MJ. Presynaptic α-autoadrenoceptors on peripheral noradrenergic neurones of newborn rabbits and dogs. In: Langer SZ, Galzin AM, Costentin J, eds. Presynaptic receptors and neuronal transporters. Pergamon Press, 1991;11-4.
61. Guimarães S, Paiva MQ, Pereira O. α-Adrenoceptor-mediated prejunctional effects of chloroethylclonidine in the canine saphenous vein. J Pharmacol Exp Ther 1997;282:1326-30.
62. c;358(suppl 2):R589.
63. a;274:117-23.
64. b;275:1656-62.
65. 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery. Br J Pharmacol 1994;113:723-8.
66. 1- adrenergic receptors revealed by chloroethylclonidine. Mol Pharmacol 1987;32:505-10.
67. 1 MF-2 and BC3H-1 clonal cell lines. Eur J Pharmacol (Mol Pharmacol) 1992;226:141-8.
68. 1-adrenoceptor recognition sites by urapidil derivatives and other selective antagonists. Br J Pharmacol 1989;97:691-700.
69. 2 adrenergic receptor functional coupling to G proteins in rat brain during postnatal development. J Pharmacol Exp Ther 1999;288:1134-42.
70. Harms HH, Zaagsma J, Van der Wal B. β-Adrenoceptor studies. III. On the β-adrenoceptors in rat adipose tissue. Eur J Pharmacol 1974;25:87-91.
71. Hein L, Spindler M, Altman JD, Kobilka BK. Alpha-2-adrenoceptor subtypes: distribution and function. Pharmacol Toxicol 1998;83(suppl I):26-8.
72. Hendersen AH, Lewis MJ, Shah AM, Smith JA. Endothelium, endocardium, and cardiac contraction. Cardiovasc Res 1992;26:305-8.
73. Hicks PE, Barras M, Herman G, Maudit P, Armstrong JM, Rossignol B. α-Adrenoceptor subtypes in dog saphenous vein that mediate contraction and inositol phosphate formation. Br J Pharmacol 1991;102:151-61.
74. 2-Adrenergic receptors: structure, function and therapeutic implications. Amsterdam: Harwood, 1997;1-18.
75. Hillarp N-A, Högberg B, Nilson B. Adenosine triphosphate in the adrenal medulla of the cow. Nature 1955;176:1032-3.
76. 2-adrenoceptor mediating prejunctional inhibition in rat atrium and cerebral cortex. Naunyn-Schmiedeberg's Arch Pharmacol 1998;357:634-9.
77. Holck MI, Jones CHM, Haeusler G. Differential interactions of clonidine and methoxamine with the postsynaptic α-adrenoceptor of rabbit main pulmonary artery. J Cardiovasc Pharmacol 1983;5:240-8.
78. 1- and β-adrenoceptor-mediated responsiveness of rat aorta. Naunyn-Schmiedeberg's Arch Pharmacol 1987;335:50-3.
79. 1D- adrenoceptors in the rat vasculature. Eur J Pharmacol 1997;322:221-4.
80. Insel PA. Adrenergic receptors - evolving concepts and clinical implications. New Engl J Med 1996;334:580-5.
81. IUPHAR. Receptor & ion channel nomenclature supplement. Trends Pharmacol Sci 1999.
82. Jones TR, Charette L, Garcia ML, Kaczorowski GJ. Interaction of iberiotoxin with beta-adrenoceptor agonists and sodium nitroprusside on guinea pig trachea. J Appl Physiol 1993;74:1879-84.
83. 3-adrenoceptor in the rat. Br J Pharmacol 1996;118:2085-98.
84. Kaumann AJ, Molenaar P. Modulation of human cardiac function through 4β-adrenoceptor populations. Naunyn-Schmiedeberg's Arch Pharmacol 1997;355:667-81.
85. rd ed. Ed Lippincott-Raven, 1997;xiii.
86. Lakatta EG. Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans. Circulation 1993;87:631-6.
87. Lands AM, Luduena FP, Buzzo HJ. Differentiation of receptors responsive to isoproterenol. Life Sci 1967;6:2241-9.
88. Langer SZ. Presynaptic regulation of catecholamine release. Biochem Pharmacol 1974;23:1793-800.
89. 2-adrenergic receptors in neonatal rat lung. J Pharmacol Exp Ther 1982;223:606-11.
90. 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 1985;329:278-81.
91. Lee E, Lee C. Clinical comparison of selective and non-selective alpha1A-adrenoceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses. Br J Urol 1997;80:606-11.
92. 2-adrenoceptors in rabbit and rat brain cortex in the absence of autoinhibition. Naunyn-Schmiedeberg's Arch Pharmacol 1989;340:639-47.
93. Ljung B, Kjellstedt A. Functional antagonism of noradrenaline responses by felodipine and other calcium antagonists in vascular smooth muscles. J Cardiovasc Pharmacol 1987;10:82s-88s.
94. 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. Proc Natl Acad Sci USA 1990;87:5094-8.
95. 1A-adrenergic receptor. J Biol Chem 1991;266:6365-9.
96. Lundberg JM, Änggärd A, Theodorsson-Norhreim E, Pernow J. Guanethidine sensitive release of neuropeptide Y-like immunoreactivity in the cat spleen by sympathetic nerve stimulation. Neurosci Lett 1984;52:175-86.
97. Lundberg JM, Terenius L, Hökfelt T, Goldstein M. High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett 1983;42:167-72.
98. Lundberg JM, Malmström RE. Peptide co-transmission in blood vessels. Pharmacol Toxicol 1998;83(suppl I):72.
99. 2-adrenergic receptor-Src protein kinase complexes. Science 1999;283:655-61.
100. 2A subtype. Br J Pharmacol 1997;121:1721-9.
101. 2a-adrenergic receptor subtype. Science 1996;273:801-5.
102. 3-adrenoceptors and intestinal motility. Fundam Clin Pharmacol 1995;9:332-42.
103. McAdams RP, Waterfall JF. The effect of age on the sensitivity of pre- and postsynaptic alpha-adrenoceptors to agonists and antagonists in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 1986;334:430-5.
104. 3H-noradrenaline by isolated hepatocytes and liver slices of the rat. Naunyn-Schmiedeberg's Arch Pharmacol 1993;348:450-7.
105. 2B-adrenoceptor subtypes. Br J Pharmacol 1989;98:890-7.
106. 1-adrenoceptor subtypes. Naunyn-Schmiedeberg's Arch Pharmacol 1995;352:1-10.
107. Miller RJ. Presynaptic receptors. Ann Rev Pharmacol Toxicol 1998;38:201-27.
108. 1-Adrenergic receptor subtypes, inositol phosphates and sources of cell calcium. Pharmacol.Rev 1988;40:87-119.
109. Minshall RD, Yelamanchi VP, Djokovic A, Mitelich DJ, Erdös EG, Rabito SF, Vogel SM. Importance of sympathetic innervation in the positive inotropic effects of bradykinin and ramiprilat. Circ Res 1994;74:441-7.
110. Miura M, Belvisi MG, Stritton CD, Yacoub MH, Barnes PJ. Role of potassium channels in bronchodilator responses in human airways. Am Rev Respir Dis 1992;146:132-6.
111. 2-autoreceptors on the sympathetic nerves of human, rat and rabbit blood vessels. Fundam. Clin Pharmacol 1993;7:372.
112. 3H-prazosin binding. Mol Pharmacol 1986;29:321-33.
113. Moura D, Paiva MQ, Vaz-da-Silva MJ, Guimarães S. Ontogenesis of beta-adrenoceptors and the adrenaline content of the adrenals. Pharmacol Toxicol 1997;81(suppl I):14.
114. 3H-noradrenaline in the saphenous vein of neonate and adult dogs. Naunyn-Schmiedeberg's Arch Pharmacol 1993;347:186-91.
115. Murphy TJ, Bylund DB. Characterization of alpha-2 adrenergic receptors in OK cell, an opossum kidney cell line. J Pharmacol Exp Ther 1988;244:571-8.
116. Mutafova-Yambolieva VN, Westfall DP. Inhibitory and facilitatory presynaptic effects of endothelin on sympathetic cotransmission in the rat isolated tail artery. Br J Pharmacol 1998;123:136-42.
117. Nahorski SR, Barnett DB, Cheung Y-D. α-Adrenoceptor-effector coupling: affinity states or heterogeneity of the α-adrenoceptor? Clin.Sci 1985;68(suppl 10):39s-42s.
118. Newhouse MJ, Hill CE. A role for neuropeptide Y in rat iridial arterioles. Am J Physiol 1997;273:H2119-27.
119. Nishizuka, Y. The role of protein kinase C in cell surface receptor signal transduction. Nature 1984;308:693-8.
120. Northup JK, Smigel MD, Sternweis PC, Gilman AG. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45.000 dalton (alpha) subunit. J Biol Chem 1983;258:11369-76.
121. O'Donnell SR, Wanstall JC. Thyroxine treatment of aged or young rats demonstrates that vascular responses mediated by β-adrenoceptors subtypes can be differentially regulated. Br J Pharmacol 1986;88:41-9.
122. Okuda M, Saito H, Urakami Y, Takano M, Inui K-I. cDNA cloning and functional expression of a novel rat kidney organic cation transporter OCT2. Biochem Biophys Res Commun 1996;224:500-7.
123. Omlor GJ, Quinn LM, Schramm CM. Ontogeny of beta-adrenergic desensitization in rabbit tracheal smooth muscle. Pediatr Pulmonol 1996;22:255-62.
124. Osswald W, Guimarães S. Adrenergic mechanisms in blood vessels: morphological and pharmacological aspects. Rev Physiol Biochem Pharmacol 1983;96:53-122.
125. Paiva MQ, Guimarães S. A comparative study of the uptake and metabolism of noradrenaline and adrenaline by the isolated saphenous vein of the dog. Naunyn-Schmiedeberg's Arch Pharmacol 1978;303:221-8.
126. 2A-autoreceptors in the canine saphenous vein. Naunyn-Schmiedeberg's Arch Pharmacol 1997;356:368-73.
127. Paiva MQ, Moura D, Vaz-da-Silva MJ, Guimarães S. Postnatal development of vascular β-adrenoceptor-mediated responses and the increase in the adrenaline content of the adrenal gland have a parallel course. Naunyn-Schmiedeberg's Arch Pharmacol 1994;350:28-33.
128. 2-adrenoceptors of the dog mesenteric and rat femoral veins. Naunyn-Schmiedeberg's Arch Pharmacol 1999; 360:165-70.
129. 1D-adrenergic receptor cDNA. Mol Pharmacol 1991;40:876-83.
130. 2- adrenergic receptor subtype. Proc Natl Acad Sci USA 1988;85:6301-5.
131. 2C-Adrenoceptor-modulated release of noradrenaline in human right atrium. Br J Pharmacol 1995;116:2617-24.
132. 1-adrenoceptor mechanisms and inhibitory effects of isradipine. Arch int Pharmacodyn 1995;330:190-205.
133. 1-adrenoceptor subtypes. Pharmacol Toxicol 1998;83(suppl I):23-5.
134. Schloss P, Mayser W, Betz H. Neurotransmitter transporters- a novel family of integral plasma membrane proteins. FEBS Lett 1992;307:76-80.
135. Schümann HJ. Über den Noradrenalin und ATP-Gehalt sympathetischer Nerven. Naunyn-Schmiedeberg's Arch Pharmacol 1958;233:296-300.
136. 1-adrenergic receptor subtype. J Biol Chem 1990;265:8183-9.
137. Starke K. Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart. Naunyn-Schmiedeberg's Arch Pharmacol 1972;274:18-45.
138. Starke K. Regulation of noradrenaline release by presynaptic receptor systems. Rev Physiol Biochem Pharmacol 1977;77:1-124.
139. Starke K. α-Adrenoceptor subclassification. Rev Physiol Biochem Pharmacol 1981;88:199-236.
140. a;34:385-8.
141. b;291:55-78.
142. 2 purinoceptors: localization, function and transduction mechanisms. Ciba Foundation Symp 198. New York: Ed John Wiley & Sons, 1996;239-59.
143. Starke K, Montel H, Gayk W, Merker R. Comparison of the effect of clonidine on pre-and postsynaptic adrenoceptor in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch Pharmacol 1974;285:133-50.
144. Starke K, Peskar BA, Schumacher JA, Taube HD. Bradykinin and postganglionic sympathetic transmission. Naunyn-Schmiedeberg's Arch Pharmacol 1977;299:23-32.
145. 2- adrenoceptors: subtype determination. Pharmacol Commun 1995;6:99-108.
146. 3H-(±)-noradrenaline in the isolated perfused rat liver. Naunyn-Schmiedeberg's Arch Pharmacol 1988;337:392-6.
147. 3- adrenoceptor. Ann Rev Pharmacol Toxicol 1997;37:421-50.
148. Strosberg AD, Pietri-Rouxel F. Function and regulation of the three β-adrenoceptor. Trends Pharmacol Sci 1996;17:373-81.
149. Stjärne L. Basic mechanisms and local modulation of nerve impulse-induced secretion of neurotransmitters from individual sympathetic nerve varicosities. Rev Physiol Biochem Pharmacol 1989;112:1-137.
150. Stjärne L, Lishajko F. Comparison of spontaneous loss of catecholamines and ATP in vitro from isolated bovine adrenomedullary gland, vas deferens and splenic nerve granules. J Neurochem 1966;13:1213-6.
151. Su C, Bevan JA, Assali NS, Brinkman CR. Development of neuroeffector mechanisms in the carotid artery of the fetal lamb. Blood Vessels 1977;14:12-24.
152. 3H)- adenosine triophosphate: release during stimulation of enteric nerves. Science 1971;173:337-9.
153. Summers RJ, Kompa A, Roberts SJ. β-Adrenoceptor subtypes and their desensitization mechanisms. J Auton Pharmacol 1997;17:331-43.
154. Toda N, Shimizu I. Neuroeffector function in mesenteric arteries isolated from beagles of different ages. J Pharmacol Exp Ther 1987;240:223-7.
155. Trendelenburg U. The extraneuronal uptake and metabolism of catecholamines. In: Trendelenburg U, Weiner N, eds. Catecholamines I. Springer-Verlag, 1988;279-312.
156. 2C-subtype mediate inhibition of norepinephrine release in human kidney cortex. Mol Pharmacol 1994;45:1168-76.
157. 2 autoreceptors in pig brain are alpha-2A. J Pharmacol Exp Ther 1996;278:462-7.
158. 2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra. Naunyn-Schmiedeberg's Arch Pharmacol 1997;356:721-37.
159. Vaz-da-Silva MJ, Magina S, Domingues-Costa A, Moura D, Guimarães S. The role of the endocardium in the facilitatory effect of bradykinin on electrically-induced release of noradrenaline in rat cardiac ventricle. Br J Pharmacol 1996;118:364-8.
160. Wahlestedt C, Yanaihara N, Hakanson R. Evidence for different pre- and postjunctional receptors for neuropeptide Y and related peptides. Regul Pept 1986;13:307-18.
161. Wanstall JC, O'Donnell SR. Influence of age on calcium entry blocking drugs in rat aorta spasmogen-dependent. Eur J Pharmacol 1989;159:241-6.
162. 2B-adrenergic receptor. Mol Pharmacol 1990;38:681-8.
163. Westfall DP, Dalziel HH, Forsyth KM. ATP as a neurotransmitter, co-transmitter, and neuromodulator. In: Phillis JW, ed. Adenosine and Adenosine Nucleotides as Regulators of Cellular Functions. Boca Raton: CRC Press, 1991;295-305.
164. Wiklund NP, Ohlen A, Cederqvist B. Adrenergic neuromodulation by endothelin in guinea pig pulmonary artery. Neurosci Lett 1989;101:269-73.
165. a;76:241-60.
166. b;76:161-272.
167. 2B-Adrenoceptor mRNA expression during rat brain development. Dev Brain Res 1997;100:90-100.
168. Xiao RP, Ji X, Lakatta EG. Functional coupling of beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol 1995;47:322-9.
169. 1-adrenoceptor subtypes with maturation and ageing in different blood vessels. Clin Exp Pharmacol Physiol 1997;24:415-7.
170. Yamamoto R, Wada A, Asada Y, Niina H, Sumiyoshi A. Nv-nitro-L-arginine, an inhibitor of nitric oxide synthesis, decreases noradrenaline outflow in rat isolated perfused mesenteric vasculature. Naunyn-Schmiedeberg's Arch Pharmacol 1993;347:238-40.
171. Yamamoto R, Wada A, Asada Y, Yanagita T, Yuhi T, Niina H, Sumiyoshi A, Kobayashi H. Nitric oxide-dependent and -independent norepinephrine release in rat mesenteric arteries. Am J Physiol 1997;272:H207-H210.
172. Zhang JX, Okamura T, Toda N. Pre- and postjunctional modulation by endothelin-1 of the adrenergic neurogenic responses in canine mesenteric arteries. Eur J Pharmacol 1996;311:169-76.
173. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 1997;51:913-21.