메뉴 건너뛰기




Volumn 2, Issue 1, 1996, Pages 3-6

Progress in molecular genetics of Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Apolipoprotein E; Dementia; Molecular genetics; Neurofibrillary tangle

Indexed keywords


EID: 0011323001     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849600200106     Document Type: Review
Times cited : (7)

References (32)
  • 2
    • 0023103748 scopus 로고
    • The genetic defect causing familial Alzheimer disease maps on chromosome 21
    • St. George-Hyslop P, Tanzi RE, Polinsky RJ, et al. The genetic defect causing familial Alzheimer disease maps on chromosome 21. Science 1987;235:885-889.
    • (1987) Science , vol.235 , pp. 885-889
    • St. George-Hyslop, P.1    Tanzi, R.E.2    Polinsky, R.J.3
  • 3
    • 0023109592 scopus 로고
    • Amyloid β-protein gene: CDNA, mRNA distributions and genetic linkage near the Alzheimer locus
    • Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid β-protein gene: cDNA, mRNA distributions and genetic linkage near the Alzheimer locus. Science 1987;235: 880-884.
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 4
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire H-G, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987;325:733-736.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 5
    • 10244268054 scopus 로고
    • Neuropathology and dementia in people with Down's syndrome
    • Davies P, Finch C, editors. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory
    • Wisniewski HM, Rabe A, Wisniewski KE. Neuropathology and dementia in people with Down's syndrome. In: Davies P, Finch C, editors. Molecular neuropathology of aging. Banbury Report. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory 1988;399-413.
    • (1988) Molecular Neuropathology of Aging. Banbury Report , pp. 399-413
    • Wisniewski, H.M.1    Rabe, A.2    Wisniewski, K.E.3
  • 6
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner G, Wong C. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.1    Wong, C.2
  • 7
    • 0028174106 scopus 로고
    • Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain but not in neurons
    • Sandbrink R, Masters CL, Beyreuther K. Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain but not in neurons. J Biol Chem 1994;269:1510-1517.
    • (1994) J Biol Chem , vol.269 , pp. 1510-1517
    • Sandbrink, R.1    Masters, C.L.2    Beyreuther, K.3
  • 8
    • 0023870043 scopus 로고
    • A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors
    • Ponte P, Gonzalez-DeWhitt P, Schilling J, et al. A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors. Nature 1988;331:525-527.
    • (1988) Nature , vol.331 , pp. 525-527
    • Ponte, P.1    Gonzalez-DeWhitt, P.2    Schilling, J.3
  • 9
    • 0025296269 scopus 로고
    • Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    • Levy E, Carman M, Fernandez-Madrid I, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990; 248:1124-1126.
    • (1990) Science , vol.248 , pp. 1124-1126
    • Levy, E.1    Carman, M.2    Fernandez-Madrid, I.3
  • 10
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin M-C, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-706.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.-C.2    Mullan, M.3
  • 11
    • 0026075602 scopus 로고
    • Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
    • Chartier-Harlin M, Crawford F, Houlden H, Warren A. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 1991;345-347.
    • (1991) Nature , pp. 345-347
    • Chartier-Harlin, M.1    Crawford, F.2    Houlden, H.3    Warren, A.4
  • 12
    • 0025925236 scopus 로고
    • The 717 Val-Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups
    • Yoshioka K, Miki T, Kaysuya T, Ogihara T, Sakaki Y. The 717 Val-Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups. Biochem Biophys Res Commun 1991;178:1141-1146.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 1141-1146
    • Yoshioka, K.1    Miki, T.2    Kaysuya, T.3    Ogihara, T.4    Sakaki, Y.5
  • 13
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M, Crawford F, Axelman K, et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1992;1:345-347.
    • (1992) Nat Genet , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3
  • 15
    • 0026648493 scopus 로고
    • Assessment of amyloid β precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases
    • Tanzi RE, Vaula G, Romano DM, et al. Assessment of amyloid β precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet 1992;51: 273-282.
    • (1992) Am J Hum Genet , vol.51 , pp. 273-282
    • Tanzi, R.E.1    Vaula, G.2    Romano, D.M.3
  • 16
    • 0023722957 scopus 로고
    • Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease
    • Schellenberg GD, Bird TD, Wijsman EM, et al. Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 1988;241: 1507-1510.
    • (1988) Science , vol.241 , pp. 1507-1510
    • Schellenberg, G.D.1    Bird, T.D.2    Wijsman, E.M.3
  • 17
    • 0023189941 scopus 로고
    • The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid B protein gene
    • Tanzi RE, St. George-Hyslop P, Haines JL, et al. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid B protein gene. Nature 1987;329:156-157.
    • (1987) Nature , vol.329 , pp. 156-157
    • Tanzi, R.E.1    St. George-Hyslop, P.2    Haines, J.L.3
  • 18
    • 0026471656 scopus 로고
    • Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14
    • Schellenberg GD, Bird TD, Wijsman EM, et al. Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14. Science 1992;258:668-671.
    • (1992) Science , vol.258 , pp. 668-671
    • Schellenberg, G.D.1    Bird, T.D.2    Wijsman, E.M.3
  • 19
    • 0027024651 scopus 로고
    • A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to α1-antichymotrypsin
    • Mullan M, Houlden H, Windelspecht M, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to α1-antichymotrypsin. Nat Genet 1992; 2:340-342.
    • (1992) Nat Genet , vol.2 , pp. 340-342
    • Mullan, M.1    Houlden, H.2    Windelspecht, M.3
  • 20
    • 0027032695 scopus 로고
    • Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
    • St. George-Hyslop P, Haines JL, Rogaev E, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet 1992;2:330-334.
    • (1992) Nat Genet , vol.2 , pp. 330-334
    • St. George-Hyslop, P.1    Haines, J.L.2    Rogaev, E.3
  • 21
    • 0027031612 scopus 로고
    • Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3
    • Van Broeckhoven C, Backhovens H, Cruts M, et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3 Nat Genet 1992;2:335-339.
    • (1992) Nat Genet , vol.2 , pp. 335-339
    • Van Broeckhoven, C.1    Backhovens, H.2    Cruts, M.3
  • 22
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 23
    • 0029150716 scopus 로고
    • A familial Alzheimer's disease locus on chromosome 1
    • Levy-Lahad E, Wijsman EM, Nemens E, et al. A familial Alzheimer's disease locus on chromosome 1. Science 1995; 269:970-972.
    • (1995) Science , vol.269 , pp. 970-972
    • Levy-Lahad, E.1    Wijsman, E.M.2    Nemens, E.3
  • 24
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 25
    • 0023731159 scopus 로고
    • Familial Alzheimer's disease in American descendants of the Volga Germans: Probable genetic founder effect
    • Bird TD, Lampe TH, Nemens EJ, Miner GW, Sumi SM, Schellenberg GD. Familial Alzheimer's disease in American descendants of the Volga Germans: probable genetic founder effect. Ann Neurol 1988;23:25-31.
    • (1988) Ann Neurol , vol.23 , pp. 25-31
    • Bird, T.D.1    Lampe, T.H.2    Nemens, E.J.3    Miner, G.W.4    Sumi, S.M.5    Schellenberg, G.D.6
  • 26
    • 0026528770 scopus 로고
    • Genetic association and linkage analysis at the apolipoprotein CII locus and familial Alzheimer's disease
    • Schellenberg GD, Boehnke M, Wijsman EM, Moore DK, Martin GM, Bird TD. Genetic association and linkage analysis at the apolipoprotein CII locus and familial Alzheimer's disease. Ann Neurol 1992;31:223-227.
    • (1992) Ann Neurol , vol.31 , pp. 223-227
    • Schellenberg, G.D.1    Boehnke, M.2    Wijsman, E.M.3    Moore, D.K.4    Martin, G.M.5    Bird, T.D.6
  • 27
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset Alzheimer disease. Proc Natl Acad Sci U S A 1993;90:1977-1981.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 28
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 29
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 30
    • 0027339923 scopus 로고
    • The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease
    • Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann Neurol 1993;34:752-754.
    • (1993) Ann Neurol , vol.34 , pp. 752-754
    • Mayeux, R.1    Stern, Y.2    Ottman, R.3
  • 31
    • 0028816355 scopus 로고
    • Apolipoprotein E and Alzheimer's disease: Ethnic variation in genotypic risks
    • Maestre G, Ottman R, Stern Y, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol 1995;37:254-259.
    • (1995) Ann Neurol , vol.37 , pp. 254-259
    • Maestre, G.1    Ottman, R.2    Stern, Y.3
  • 32
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995;373:523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.