In vitro maturation of human neonatal CD4 T lymphocytes: I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12

Journal of Immunology

Volumn 152, Issue 3, 1994, Pages 1141-1153

  Wu, Chang You ^a   Demeure, Christian E ^a   Gately, Maurice ^b   Podlaski, Frank ^b   Yssel, Hans ^c   Kiniwa, Mamoru ^a   Delespesse, Guy ^a  

^a NOTRE DAME HOSPITAL   (Canada)

^b HOFFMANN LA ROCHE INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD45 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CULTURE MEDIUM; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; NEWBORN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD; ANTIGENS, CD31; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; HUMANS; IMMUNOPHENOTYPING; INFANT, NEWBORN; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKINS; MEMBRANE GLYCOPROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; TIME FACTORS;

EID: 0011191015     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Sher, A., and R. L. Coleman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
2. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine Leishmaniasis. J. Exp. Med. 169:59.
3. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
4. + T cells. Immunol. Rev. 123:209.
5. + T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol. Rev. 123:23.
6. Kay, A. B., Q. Hamid, D. S. Robinson, A. M. Bentley, A. Tsicopoulos, S. Ying, R. Moqbel, C. J. Corrigan, and S. R. Durham. 1992. T lymphocytes/eosinophil interactions in atopic asthma: critical role for interleukin-5. In Progress in Immunology VIII. J. Gergely, M. Benczúr, A. Erdei, A. Falus, G. Y. Fust, G. Medgyesi. G. Y. Petrányi, E. Rasnavölgyl, eds. Springer Hungarica, Budapest, p. 403.
7. Romagnani, S., G. F. Del Prete, E. Maggi, P. Parronchi, M. De Carli, R. Manetti, M.-P. Piccinni, F. Almerigogna, M. G. Giudizi, R. Biagiotti, and S. Sampognaro. 1992. Human Th1 and Th2 cells: regulation of development and role in protection and disease. In Progress in Immunology VIII. J. Gergely, M. Benczúr, A. Erdei, A. Falus, G. Y. Füst, G. Medgyesi, G. Y. Petrányi, E. Rasnavölgyl, eds. Springer Hungarica, Budapest, p. 239.
8. + T cells producing IL-2 and IL-4. J. Immunol. 148:1031.
9. Reiner, S. L., Z. E. Wang, F. Hatam, P. Scott, and R. M. Locksley. 1993. Common lineage of Th1 and Th2 subsets in Leishmaniasis. Science 259:1457.
10. Abehsira-Amar, O., M. Gilbert, M. Joliym, J. Theze, and D. L. Jankovic. 1992. IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J. Immunol. 148:3820.
11. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Helper. 1991. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123: 115.
12. + T-cell subsets in vivo. Immunol. Rev. 123:189.
13. + T helper cell subsets. Curr. Opin. Immunol. 5:391.
14. Fitch, F. W., M. D. McKisic, D. W. Lancki, and T. F. Gajewski. 1993. Differential regulation of murine T lymphocyte subsets. Annu. Rev. Immunol. 11:29.
15. Murray, J. S., J. Madri, T. Pasqualini, and K. Bottomly. 1993. Functional CD4 T cell subset interplay in an intact immune system. J. Immunol. 150:4270.
16. Doherty, T. M., and R. L. Coffman. 1993. Leishmania antigens presented by GM-CSF-derived macrophages protect susceptible mice against challenge with Leishmania major. J. Immunol. 150:5476.
17. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091.
18. Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin-4 (IL-4) producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
19. Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
20. Hsieh, C. S., A. B. Heimberger, J. Gold, A. O'Garra, and K. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89:6065.
21. Chatelain, R., K. Varikila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148: 1182.
22. Tanaka, T., J. Hu-Li, R. A. Seder, B. Fazekas de St. Groth, and W. E. Paul. 1993. Interleukin 4 suppresses interleukin 2 and interferon γ production by naive T cells stimulated by accessory cell-dependent receptor engagement. Proc. Natl. Acad. Sci. USA 90:5914.
23. + T cells occurs through macrophage production of IL-12. Science 260:547.
24. Trinchieri, G. 1993. Interleukin-12 and its role in the generation of Th1 cells. Immunol. Today 14:335.
25. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin-12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
26. Sypek, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous Leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
27. Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:42.
28. Swain, S. L., G. Huston, S. Tonkonogy, and A. Weinberg. 1991. Transforming growth factor-β and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol. 147:2991.
29. Scott, P. 1991. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous Leishmaniasis. J. Immunol. 147:3149.
30. Finkelman, F. D., A. Svetic, I. Gresser, C. Snapper, J. Holmes, P. P. Trotta, I. M. Katona, and W. C. Gause. 1991. Regulation by interferon α of immunoglobulin isotype selection and lymphokine production in mice. J. Exp. Med. 174:1179.
31. D'Andrea, A., M. Rengaraju, N. M. Vallante, J. Chemhimi, M. Kubin, M. Aste, S, H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. T. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (NKSF) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
32. Barral-Netto, M., A. Barral, C. E. Brownell, Skeiky Yaw, L. R. Ellingsworth, D. R. Twardzik, and S. G. Reed. 1992. Transforming growth factor-β in Leishmanial infection: a parasite escape mechanism. Science 257:545.
33. Haas, W., P. Pereira, and S. Tonegawa. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637.
34. Seder, R. A., W. E. Paul, A. M. Dvorak, S. J. Scharkis, A. Kagey-Sobotka, J. Niv, F. D. Finkelman, S. A. Barbieri, S. J. Galli, and M. Plaut. 1991. Mouse splenic and bone marrow cell populations that express high affinity Fee receptors and produce interleukin 4 are highly enriched in basophils. Proc. Natl. Acad. Sci. USA 88:2835.
35. Romagnani, S. 1992. Induction of Th1 and Th2 responses: a key role for the natural immune response? Immunol. Today 13:379.
36. Manetti, R., P. Parronchi, M. G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1199.
37. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. Mc-Comas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143.
38. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y.-C. E. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Truitt, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87: 6808.
39. Thiele, D. L., and P. E. Lipsky. 1985. Modulation of human natural killer cell function by L-leucine methyl ester: Monocyte-dependent depletion from human peripheral blood mononuclear cells. J. Immunol. 134:786.
40. Kiniwa, M., M. Gately, U. Gubler, R. Chizzonite, C. Fargeas, and G. Delespesse. 1992. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J. Clin. Invest. 90:262.
41. Wu, C., C. Demeure, M. Kiniwa, M. Gately, and G. Delespesse. 1993. IL-12 induces the production of IFN-γ by neonatal human CD4 T cells. J. Immunol. 151:1938.
42. Fargeas, C., C. Y. Wu, T. Nakajima, D. Cox, T. Nutman, and G. Delespesse. 1992. Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes. Eur. J. Immunol. 22:2173.
43. + T cell clones from a human chimera produce IL-5, IL-2, IFN-γ and granulocyte/macrophage-colony-stimulating factor but not IL-4. J. Immunol. 144:902.
44. + T cell clones and peripheral blood T cells. J. Immunol. 149:2378.
45. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, K. Moore, and J. Silver. 1992. Strategies and practice of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
46. + αβ-TCR transgenic T cells is macrophage dependent. Int. Immunol. 5:371.
47. Peleman, R., J. Wu, C. Fargeas, and G. Delespesse. 1989. Recombinant interleukin 4 suppresses thes production of interferon γ by human mononuclear cells. J. Exp. Med. 170:1751.
48. Beverley, P. C. L. 1992. Functional analysis of human T cell subsets defined by CD45 isoform expression. Semin. Immunol. 4:35.
49. Paliard, X., R. de Waal Malefijt, J. E. de Vries, and H. Spits. 1988. Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones. Nature 335:642.
50. Torimoto, Y., D. M. Rothstein, N. H. Dang, S. F. Schlossman, and C. Morimoto. 1992. CD31, a novel cell surface marker for CD4 cells of suppressor lineage, unaltered by state of activation. J. Immunol. 148:388.
51. Paul, W. E., R. A. Seder, J. Hu-Li, T. Tanaka, and S. Z. Ben-Sasson. 1992. IL-4 is a major determinant of T cell lymphokine-producing phenotype. In Progress in Immunology VIII. J. Gergely, M. Benczür, A. Erdei, A. Falus, G. Y. Füst, G. Medgyesi, G. Y. Petranyl, E. Rajhavölgyi, eds. Springer Hungarica, Budapest, p. 347.
52. Harris, D. T., M. J. Schumacher, J. Locascio, F. J. Besencon, and E. A. Boyse. 1992. Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proc. Natl. Acad. Sci. USA 89:10006.
53. Clerici, M., L. De Palma, E. Roilides, R. Baker, and G. M. Shearer. 1993. Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages. J. Clin. Invest. 91:2829.
54. + T cells in the human. Immunol. Res. 10:239.
55. Ehlers, S., and K. A. Smith. 1991. Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J. Exp. Med. 173:25.
56. Naume, B., M. K. Gately, B. B. Desai, A. Sundan, and T. Espevik. 1993. Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation. Cytokine 5:38.
57. Kopf, M., G. Le Gros, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Köhler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245.
58. Steel, C., and T. B. Nutman. 1993. Regulation of IL-5 in onchocerciasis. J. Immunol. 150:5511.
59. Yamaguchi, Y., T. Suda, H. Shiozaki, Y. Miura, Y. Hitoshi, A. Tominaga, K. Kasahara, and T. Kasahara. 1990. Role of IL-5 in IL-2-induced eosinophilia; in vivo and in vitro expression of IL-5 mRNA by IL-2. J. Immunol. 145:873.
60. Stockinger, H., W. Schreiber, O. Majdic, W. Holter, D. Maurer, and W. Knapp. 1992. Phenotype of human T cells expressing CD31, a molecule of the immunoglobulin supergene family. Immunology 75: 53.
61. Yssel, H., K. E. Johnson, P. V. Schneider, J. Wideman, A. Terr, R. Kastelein, and J. E. de Vries. 1992. T cell activation-inducing epitopes of the house dust mite allergen Der p I. J. Immunol. 148:738.
62. Zehnder, J. L., K. Hirai, M. Shatsky, J. L. McGregor, L. J. Levitt, and L. L. K. Leung. 1992. The cell adhesion molecule CD31 is phosphorylated after cell activation. J. Biol. Chem. 267:5243.