PKC Inhibitors in the Therapy of Autoimmune Diseases

Current Pharmaceutical Design

Volumn 2, Issue 6, 1996, Pages 596-609

  Wilkinson, S E ^a   Nixon, J S ^a  

^a ROCHE PRODUCTS LTD   (United Kingdom)

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EID: 0010739174     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (80)

1. Sell, S. Inflammation, Immunopathology and Immunity, Elsevier: New York, 1987.
2. Keranen, L.M; Dutil, E.M, Newton, A.C. Current Biology 1995; Vol 5, pp 1394-1404
3. Wilkinson. S.E; Hallam, T.J. TiPS 1994; Vol 15, pp 53.
4. Ahmed, S; Kozma, R; Monfries, C; Hall, C; Lim, H.H; Smith, P; Lim, L. Biochem. J. 1990; Vol 272, pp 767-773.
5. Ahmed, S; Lee, J; Best, A; Monfries, C; Lim, L. J.Biol.Chem. 1993; Vol 268 pp.10709-10712.
6. Nishizuka, Y. Nature 1984; Vol 308, pp. 693-698.
7. Birchall, A.M; Bishop, J, Bradshaw, D; Cline, A; Coffey, J; Elliott, L.H; Gibson, V.M; Greenham, A; Hallam, T.J; Harris, W; Hill, C.H; Hutchings, A; Lamont, A.G; Lawton, G; Lewis, E.J; Maw, A; Nixon, J.S; Pole, D; Wadsworth, J; Wilkinson, S.E. J. Pharmacol. Exp. Ther. 1994; Vol 268, pp. 922-929.
8. Ruegg, U.T, Burgess, G.M. Trends Biochem. Sci. 1989; Vol 10, pp 218-220.
9. Elliott, L.H; Wilkinson, S.E; Sedgwick, A.D; Hill, C.H; Lawton, G; Davis, P.D; Nixon, J.S. Biochem. Biophys. Res. Comm. 1990; Vol 171, pp 148-154.
10. Mizuno, K; Noda, K; Ueda, Y; Hanaki, H; Saido, T.C; Ikuta, T; Tamaoki, T; Hirai, S; Oasada, S. FEBS Letts 1995; Vol 359, pp 259-261.
11. Wilkinson, S.E; Parker, P.J; Nixon, J.S. Biochem. J 1993; Vol 294, pp.641-647
12. Zang, R; Muller, H-J; Kielbassa,K; Biochem J. 1994; Vol 304, pp 641-647.
13. Mizuno, K; Saido, T.C; Ohno, S; Tamoaki, T; Suzuki, K; FEBS Letts. 1993; Vol 330, PP 114-116.
14. Nixon, J.S; Wilkinson, S.E; Davis, P.D; Sedgwick, A D; Wadsworth, J; Westmacott, D; Agents and Actions 1991; Vol 32, pp. 188-193.
15. Nakajima, K; Kusafuka, T; Takeda, T; Fujitani, Y; Nakae, K; Hirano, T; Mol. Cell. Biol. 1993, Vol 13, pp 3027-3041.
16. Kobayashi, E; Nakano,H; Morimoto, M; Tamaoki,T. Biochem Biophys. Res. Comm. 1989; Vol 159pp. 548-553.
17. Diwu, Z; Zimmerman, J; Meyer, T; Lown, J.W. Biochem. Pharmacol. 1994; Vol. 47, pp 373-385.
18. Bruns, R.F; Miller, F.D; Mernman, R.L; Howbert, J,J; Heath, W.F; Kobayashi, E; Takahashi, I; Tamaoki, T, Nakano, H. Biochem. Biophys. Res. Comm. 1991; Vol 51, pp 288-293.
19. Hannun, Y.A; Bell, R.M. Science 1989; Vol 243, pp 500-507.
20. Areces, L B; Kazanietz, M.G; Blumberg, P.M. J.Biol.Chem. 1994; Vol 269, pp 21309-21316.
21. Merrill Jnr, A.H; Nimkar, S; Menaldino, D; Hannun, Y.A; Loomis, C; Bell, R.M; Tyagi, S.R; Lambeth, J.D. Stevens, V L; Hunter, R. Biochemistry. 1989; Vol 28, pp 3138-3145.
22. Franson, R.C; Harris, L.K; Ghosh, S.S; Rosenthal, M.D. Biochem. Biophys. Acta. 1992; Vol 1136, pp 169-174.
23. Tegeler, J.J; Rauckman, B S; Hamer, R.R.L; Freed, B.S; Merriman, G.H; Hellyer, L; Ortega-Nanos, M; Bailey, S.C; Kurtz, E.S; Bioorg. Med. Letts. 1995; Vol. 5, pp 2477-2482.
24. Merriman, G; Tegeler, J.J; Hamer, R.R.L; Rauckman, B.S; Freed, B.S; Kurtz, E.S; Bailey, S C; Ortega-Nanos, M; Przekop, P.A; Hellyer, L. Bioorg. Med. Letts. 1995; Vol. 5 pp 2483-2488.
25. Endo, K; Igarashi, Y; Nisar, M; Zhou, Q.H; Hakamori, S. Cancer Res. 1991; Vol. 51, pp 1613-1618.
26. Sullivan, J.P; Connor, J.R; Shearer, B.G; Burch, R.M. Mol Pharmacol. 1991; Vol. 41, pp 38-44.
27. Jiang, J.B; Johnson, M.G; Defauw, J.M; Defaww, J.M; Beine, T M; Ballas, L,M; Janzen, W,P; Loomins, C,R; Seldin, J; Cofield, D; Adams, L. J. Med. Chem. 1992; Vol 35 pp 4259-4263.
28. House, C; Kemp, B.E. Science, 1987, Vol 238, pp 4839-4844.
29. House, C; Kemp, B.E. Cell. Signalling 1990; Vol 2, pp 187-190.
30. Alexander, D.R; Hexham, J.M; Lucas, S.C; Graves, J D; Cantrell, D. A; Crumpton, M.J. Biochem. J. 1989, Vol. 268, pp 303-308.
31. Eicholtz, T; de Bont, D.B; deWidt, J; J.Biol.Chem. 1993; Vol 268, pp 1982-1086.
32. O'Brian, C; Ward, N.E; Liskamp, R.M; de-Bront, D.B; van-Boom, J.H. Biochem. Pharmacol. 1990, Vol. 39 pp 49-57.
33. Balboa, M.A: Firestein, B.L; Godson, C; Bell, K.S; Insel, P.A. J.Biol.Chem. 1994, Vol 269, pp 10511-10516.
34. Takahashi, I; Kobayashi, E; Asano, K; Yoshida, M; Nakano, H.J. Antibiot. 1987, Vol 40, pp 1782-1784.
35. Mizuno, K; Saido, T.C; Ohno, S; Tamaoki, T; Suzuki, K. FEBS Lens. 1993; Vol. 330, pp 114-116.
36. Wang, Q; Worland, P.J; Clark, J.L; Carlson. B.A; Sausville, E.A. Cell Growth and Differentiation 1995; Vol. 6, pp 927-936..
37. Akinga, S; Gomi, K; Morimoto, M; Tamaoki, T; Okabe, M. Cancer Res. 1991; Vol. 51, pp 4888-4892.
38. Meyer, T; Regenass, U; Fabbro, D; Alteri, E; Rosel, J; Muller, M; Caravatti, G; Matter, A. Int. J. Cancer 1989; Vol. 43, pp 851-856.
39. Marte, B.M; Meyer, T; Stabel, S; Standke, G.J; Jaken, S; Fabbro, D; Hynes, N,E. Cell Growth Differ. 1994; Vol. 5, pp 239-247.
40. Martiny-Baron, G; Kazanietz, M.G; Mischak, H; Blumberg, P.M; Kochs, G; Hug, H; Marme, D; Schachtele, C. Cancer Res. 1993; Vol. 268, pp 9194-9197.
41. Zang, R; Muller, H-J; Kielbassa, K; Marks, F Gschwendt, M. Biochem. J 1994; Vol. 304, pp 641-647.
42. Davis, P D; Hill, C.H; Lawton, G; Nixon, J.S; Wilkinson, S E; Hurst, S.A. Keech, E; Turner , S.E. J. Med. Chem 1992: Vol. 35, pp177-184.
43. Gerber, P.R; Gubernator, K; Mueller, K; Helv. Chm. Acta 1988, Vol. 71, pp 2887-2892
44. Davis, P.D; Elliott, L H; Harris, W; Hill, C.H; Hurst, S.A; Keech, E; Kumar, M.K.H; Lawton, G; Nixon J.S, Wilkinson, S.E. J. Med. Chem. 1992, Vol 35, pp 994-1001.
45. Bit, R.A; Davis, P.D; Elliott, L.H, Harris, W; Hill, C.H; Keech, E; Kumar, M.K.H; Lawton, G; Maw, A; Nixon J.S; Vesey, D.R; Wadsworth, J; Wilkinson, S.E J. Med. Chem. 1993, Vol 36, pp 21-29.
46. Muid, R.E; Dale, M.M; Davis, P.D; Elliott, L.H; Hill, C.H; Kumar, M.K H; Lawton, G; Twomey, B.M; Wadsworth, J; Wilkinson, S.E; Nixon, J.S. .FEBS Letts. 1991, Vol 293, pp 169-172.
47. Dicorlleto, P.E; de la Motte, C.A. Biochem J. 1989; Vol 264, pp 71-77.
48. Twomey, B; Muid, R.E; Dale, M.M. Br. J. Pharmacol. 1990; Vol 100 pp 819-825.
49. Uings, I.J. Thompson ,N.T; Randall, R.W; Spacey, G.D; Bonser, R.W; Hudson, A.T; Garland, L.G. Biochem. J. 1992; Vol 281 pp 597-600.
50. Merritt, J.E; Tse, J; Sullivan, S.E; Nixon,J.S; Hallam, T J. Cellular Signalling, 1996 in press.
51. Wenzel-Seifert, K; Schachtele, C; Seifert, R Biochem. Biophys. Res. Comm. 1994, Vol 200, pp 1536-1543..
52. Twomey, B; Muid, R.E; Nixon, J.S., Sedgwick, A.D; Wilkinson, S.E; Dale, M.M. Biochem. Biophys. Res. Comm. 1990. Vol 171. pp 1087-1092
53. Lindsay, M; Daniels, I; Fletcher, J; Biochem. Soc. Trans. 1996, Vol 24, 67S.
54. Bengis-Garber, C; Gruener, N; Cellular Signalling 1995. Vol 7, pp 721-732.
55. Dewald, B; Thelen, M; Wymann,M.P; Bagglioni, M; Biochem. J. 1989, pp 879-884.
56. Kankaanranta, H; Moilanen, E; Lindberg, K; Vapaatalo, H. Biochem. Pharmacol. 1995, Vol 50, pp197-203.
57. Keller; H.U; J. Cell. Physiol. 1990; Vol. 145, pp 465-471.
58. Keller; H.U; Niggli, V. J. Cell. Physiol. 1994; Vol. 161, pp 526-536.
59. Coffey, R.G; Weakland, L,L; Alberts, V.A. Immunology, 1992, Vol 76, pp 48-54.
60. Mege, J.L; Sanguedolce, MV; Jacob, T; Bongrand, P; Capo, C; Myssiakine, E.B; Barot-Ciorbaru, R. Eur. J. immunol. 1993, Vol 23, pp 1582-1587.
61. Sampson, L.E; Mire-Sluis, A; Meager, A. Biochem. J. 1993. Vol. 292, pp 289-294.
62. Severn, A; Wakelam, M.J; Liew, F.Y; Biochem. Biophys. Res. Comm. 1992 Vol 188, pp 997-1002.
63. Hortelano, S; Genaro, A.M; Bosca, L. FEBS Letts. 1993, Vol 320, pp 135-139.
64. Paul, A; Pendreigh, R.W; Plevin, R; Br. J. Pharmacol. 1995, Vol 114, pp 482-488
65. Conroy, L; Merritt, J,E; Hallam,T,J. Biochem. J. 1994, Vol 303, pp 671-677.
66. Williams, D.H; Hallam, T.J; Murray, E.J. Biochem. Soc. Trans. 1993, Vol 21, 383s.
67. Williams, D.H; Woodrow, M; Cantrell, D.A; Murray, E.J. Eur. J.Immunol. 1995, Vol 25, pp 42-47.
68. Gieselhart, L; Conti, D.J; and Freed, B.M; Transplantation, 1996, Vol. 51 pp 1637-1642.
69. Ravichandran, K.S; Burakoff, S.S. J.Exp.Med. 1994, Vol 179, pp 727-732.
70. Andersen, G; Andersen, K.L; Conroy, L, A; Hallam, T.J; Moore, N'C; Owen, J.J.T; Jenkinson, T.J; J. Immunol. 1995, Vol 154, pp 3636-3643.
71. Southern, C; Wilkinson, P.C; Thorp, K,M; Henderson, L.K; Nemec, M. Matthews, N. Immunol. 1995, Vol 84, pp 326-332.
72. Gold, M.R; Sanghera, J.S; Stewart, J; Pelech, S.L; Biochem. J. 1992, Vol 287, pp 269-276.
73. Cambier, J.C; Fisher, C.L; Pickles, H; Morrison, D.C; J. Immunol. 1990, Vol 145, pp 13-19.
74. Katira, A; Knox, K.A; Finney, M; Michell, R.H; Wakelam, M; Gordon, J; Clin. Exp Immunol. 1993, Vol 92, pp 347-352.
75. Knox, K A; Finney, M; Milner, A.E; Gregory, C.D; Wakelam, M.J; Michell, R.H; Gordon, J. Int J. Cancer 1992; Vol 52, pp 959-966.
76. Mulqueen, M.J; Bradshaw, D; Davis, P.D; Elliott, L.H; Griffiths, T.A; Hill, C.H; Kumar, H; Lawton, G; Nixon, J.S; Sedgwick, A.D; Wadsworth, J; Westmacott, D; Wilkinson, S.E, Agents and Actions 1992, pp 85-89.
77. Bishop, J; Greenham, A.K; Lewis, E.J; Pole, D.S. Eu. J. Rheam. & Inflamm. 1993, pp 17-20.
78. Heber-Katz, E. Autoimmunity Physiol. and Disease. 1994, pp353-366.
79. Lassman, H; Vass, K; Brunner, C; Seitelburger, F. Progress in Neuropathology, Ed. Zimmerman, H.M. Raven Press, New York, Vol 6, pp 33-62.
80. Matsumoto, Y; Fujiwara, M; J. Neurol. Sci. 1987, Vol 77, pp35-47.