Mutational analysis of 26 residues of vaccinia DNA topoisomerase identifies Ser-204 as important for DNA binding and cleavage

Biochemistry

Volumn 36, Issue 26, 1997, Pages 7944-7950

  Wang, Li Kai ^a   Wittschieben, John ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; SERINE; VIRUS DNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANALYTIC METHOD; ARTICLE; CARBOXY TERMINAL SEQUENCE; COVALENT BOND; DNA BINDING; DNA CLEAVAGE; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; ESTERIFICATION; GENE MUTATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS; VACCINIA;

ALANINE; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; DNA MUTATIONAL ANALYSIS; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DNA, VIRAL; MAGNESIUM; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SERINE; SODIUM CHLORIDE; VACCINIA VIRUS; VIRAL PROTEINS;

POXVIRIDAE; VACCINIA; VACCINIA VIRUS;

EID: 0010286274     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970498q     Document Type: Article

References (34)

1. Been, M. D., Burgess, R. R., & Champoux, J. J. (1984) Nucleic Acids Res. 12, 3097-3114.
2. Benedetti, P., Fiorani, P., Capuani, L., & Wang, J. C. (1993) Cancer Res. 53, 4343-4348.
3. Caron, P. R., & Wang, J. C. (1994) Adv. Pharmacol. 29B, 271-297.
4. Cheng, C., Wang, L. K., Sekiguchi, J., & Shuman S. (1997) J. Biol. Chem. 272, 8263-8269.
5. Edwards, K. A., Halligan, B. D., Davis, J. L., Nivera, N. L., & Liu, L. F. (1982) Nucleic Acids Res. 10, 2565-2576.
6. Gupta, M., Fujimori, A., & Pommier, Y. (1995) Biochim. Biophys. Acta 1262, 1-14.
7. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) Gene 77, 51-59.
8. Jaxel, C., Capranico, G., Kerrigan, D., Kohn, K. W., & Pommier, Y. (1991) J. Biol. Chem. 266, 20418-20423.
9. Klemperer, N., Lyttle, D. J., Tauzin, D., Traktman, P., & Robinson, A. J. (1995) Virology 206, 203-215.
10. Lue, N., Sharma, A., Mondragon, A., & Wang, J. C. (1995) Structure 3, 1315-1322.
11. Morham, S. G., & Shuman, S. (1990) Genes Dev. 4, 515-524.
12. Morham, S. G., & Shuman, S. (1992) J. Biol. Chem. 267, 15984 -15992.
13. Petersen, B. Ø., & Shuman, S. (1997) J. Biol. Chem. 272, 3891-3896.
14. Petersen, B. Ø., Wittschieben, J., & Shuman, S. (1996) J. Mol. Biol. 263, 181-195.
15. Rubin, E., Pantazis, P., Bharti, A., Toppmeyer, D., Giovanella, B., & Kufe, D. (1994) J. Biol. Chem. 269, 2433-2439.
16. Sekiguchi, J., & Shuman, S. (1994a) J. Biol. Chem. 269, 29760-29764.
17. Sekiguchi, J., & Shuman, S. (1994b) Nucleic Acids Res. 22, 5360-5365.
18. Sekiguchi, J., & Shuman, S. (1994c) J. Biol. Chem. 269, 31731-31734.
19. Sekiguchi, J., & Shuman, S. (1995) J. Biol. Chem. 270, 11636-11645.
20. Sekiguchi, J., & Shuman, S. (1996) EMBO J. 15, 3448-3457.
21. Senkevich, T. G., Bugert, J. J., Sisler, J. R., Koonin, E. V., Darai, G., & Moss, B. (1996) Science 273, 813-816.
22. Sharma, A., Hanai, R., & Mondragon, A. (1994) Structure 2, 767-777.
23. Shuman, S. (1991) J. Biol. Chem. 266, 11372-11379.
24. Shuman, S. (1992) J. Biol. Chem. 267, 8620-8627.
25. Shuman, S., & Moss, B. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 7478-7482.
26. Shuman, S., & Prescott, J. (1990) J. Biol. Chem. 265, 17826-17836.
27. Shuman, S., Golder, M., & Moss, B. (1988) J. Biol. Chem. 263, 16401-16407.
28. Shuman, S., Kane, E. M., & Morham, S. G. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 9793-9797.
29. Stivers, J. T., Shuman, S., & Mildvan, A. S. (1994)'Biochemistry 33, 327-339.
30. Upton, C., Opgenorth, A., Traktman, P., & McFadden, G. (1990) Virology 176, 439-447.
31. Wang, J. C. (1996) Annu. Rev. Biochem. 65, 635-692.
32. Wang, L. K., & Shuman, S. (1997) Biochemistry (in press).
33. Wittschieben, J., & Shuman, S. (1994) J. Biol. Chem. 269, 29978-29983.
34. Zantige, J. L., Krell, P. J., Derbyshire, J. B., & Nagy, E. (1996) J. Gen. Virol. 77, 603-614.