Analysis of antibody response to invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi

Infection and Immunity

Volumn 67, Issue 12, 1999, Pages 6702-6706

  Liang, Fang Ting ^a   Philipp, Mario T ^a  

^a TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE ANTIGEN;

ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ANTIGENICITY; ARTICLE; BORRELIA BURGDORFERI; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE SYSTEM; IMMUNOGENICITY; NEISSERIA GONORRHOEAE; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRYPANOSOMA;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENIC VARIATION; ANTIGENS, BACTERIAL; ANTIGENS, SURFACE; BACTERIAL PROTEINS; BORRELIA BURGDORFERI GROUP; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIPOPROTEINS; LYME DISEASE; MACACA MULATTA; MICE; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA;

EID: 0010185122     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Barbet, A. F., and T. C. McGuire. 1978. Crossreacting determinants in variant-specific surface antigens of African trypanosomes. Proc. Natl. Acad. Sci. USA 75:1989-1993.
2. Barony, G., and R. B. Merrifield. 1980. The peptides: analysis, synthesis, and biology, p. 3-285. Academic Press, Inc., New York, N.Y.
3. Barstad, P. A., J. E. Coligan, M. G. Raum, and A. G. Barbour. 1985. Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J. Exp. Med. 161:1302-1314.
4. Borst, P., and G. A. M. Cross. 1982. Molecular basis for trypanosome antigenic variation. Cell 29:291-303.
5. Borst, P., W. Bitter, P. A. Blundell, I. Chaves, G. A. M. Cross, H. Gerrits, F. van Leeuwen, R. McCulloch, M. Taylor, and G. Rudenko. 1998. Control of Vsg gene expression sites in Trypanosoma brucei. Mol. Biochem. Parasitol. 91:67-76.
6. Borst, P. 1991. Molecular genetics of antigenic variation. Immunol. Today 12:A29-A33.
7. Bunikis, J., and A. G. Barbour. 1999. Access of antibody or trypsin to an integral outer membrane protein (P66) of Borrelia burgdorferi is hindered by Osp lipoproteins. Infect. Immun. 67:2874-2883.
8. Centers for Disease Control and Prevention. 1997. Case definition for infectious conditions under public health surveillance. Morbid. Mortal. Weekly Rep. 46:20-21.
9. Cross, G. A. M. 1979. Crossreacting determinants in the C-terminal region of trypanosome variant surface antigens. Nature 277:310-312.
10. Forest, K. T., S. L. Bernstein, E. D. Getzoff, M. So, G. Tribbick, H. M. Geysen, C. D. Deal, and J. A. Tainer. 1996. Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies. Infect. Immun. 64:644-652.
11. Hagblom, P., E. Segal, E. Billyard, and M. So. 1985. Intragenic recombination leads to pilus antigenic variation in Neisseria gonorrhoeae. Nature 315: 156-168.
12. Liang, F. T., A. L. Alvarez, Y. Gu, J. M. Nowling, R. Ramamoorthy, and M. T. Philipp. An immunodominant conserved region within the variable domain of VlsE, the variable surface antigen of Borrelia burgdorferi. J. Immunol., in press.
13. Meier, J. T., M. I. Simon, and A. G. Barbour. 1984. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell 41:403-409.
14. Pays, E., and D. P. Nolan. 1998. Expression and function of surface proteins in Tiypanosoma brucei. Mol. Biochem. Parasitol. 91:3-36.
15. Philipp, M. T., M. K. Aydintug, R. P. Bohm, Jr., F. B. Cogswell, V. A. Dennis, H. N. Lanners, R. C. Lowrie, Jr., E. D. Roberts, M. D. Conway, M. Karaçorlu, G. A. Peyman, D. J. Gubler, B. J. B. Johnson, J. Piesman, and Y. Gu. 1993. Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans. Infect. Immun. 61:3047-3059.
16. Philipp, M. T., Y. Lobet, R. P. Bohm, Jr., E. D. Roberts, V. A. Dennis, Y. Gu, R. C. Lowrie, Jr., P. Desmons, P. H. Duray, J. England, P. Hauser, J. Piesman, and K. Xu. 1997. The outer surface protein A (OspA) vaccine against Lyme disease: efficacy in the rhesus monkey. Vaccine 15:1872-1884.
17. Reinitz, D. M., B. D. Aizenstein, and J. M. Mansfield. 1992. Variable and conserved structural elements of the trypanosome variant surface glycoprotein. Mol. Biochem. Parasitol. 51:119-132.
18. Restrepo, B. I., T. Kitten, C. J. Carter, D. Infante, and A. G. Barbour. 1992. Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol. Microbiol. 6:3299-3311.
19. Rothbard, J. B., R. Fernandez, and G. K. Schoolnik. 1984. Strain-specific and common epitopes of gonococcal pili. J. Exp. Med. 160:208-221.
20. Stoenner, H. G., T. Dodd, and C. Larsen. 1982. Antigenic variation of Borrelia hermsii. J. Exp. Med. 156:1297-1311.
21. Zhang, J. R., J. M. Hardham, A. G. Barbour, and S. J. Norris. 1997. Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell 89:275-285.