Exposure of cultured microglial cells to interferon-gamma

Alternatives to Laboratory Animals

Volumn 24, Issue 3, 1996, Pages 377-385

  Grundt, Inger K ^a   Nyland, Harald ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Interferon gamma; Interleukin 1 ; MHC class II; Microglial morphology; Mixed glial cell cultures; Time lapse film

Indexed keywords

EID: 0010051990     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Hayes, G.M., Woodroofe, M.N. & Cuzner, M.L. (1987). Microglia are the major cell type expressing MHC class II in human white matter. Journal of Neurological Sciences 80, 25-37.
2. Giulian, D., Baker, T.J., Shih, L.N. & Luchman, L.B. (1986). Interleukin-1 of the central nervous system is produced by amoeboid microglia. Journal of Experimental Medicine 164, 594-604.
3. Thomas, W.E. (1992). Brain macrophages: evolution of microglia and their functions. Brain Research Reviews 17, 61-74.
4. Billiau, A. (1995). Interferons in multiple sclerosis: warning from experiences. Neurology 45, Suppl. 6, 50-53.
5. Streit, O.J , Graeber, M.B. & Kreutzberg, G.W. (1988). Functional plasticity of microglia: a review. GLIA 1, 301-307.
6. Imamura, K., Suzumura, A., Sawada, M., Mabuehi, C. & Marunouchi, T. (1994). Induction of MHC class II antigen expression on murine microglia by interleukin-3. Journal of Neuroimmunology 55, 119-125.
7. Dickson, D.W., Lee, S.C., Mattiace, L.A., Yen, S-H. & Brosnan, C. (1993). Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. GLIA 7, 75-83.
8. Rothwell, N.J. & Hopkins, S.J. (1995). Cytokines and the nervous system. II. Actions and mechanisms. Trends in Neurological Sciences 18, 130-136.
9. Kimber, I. (1994). Chemical allergy: cellular and molecular mechanisms and novel approaches to predictive testing. Toxicology in Vitro 8, 987-990.
10. Hetier, E., Ayala, J., Denefle, P., Bousseau, A., Rouget, P., Mallat, M. & Prochiantz, A. (1988). Brain macrophages synthesize interleukin-1 and interfeukin-1 mRNAs in vitro. Journal of Neuroscience Research 21, 391-397.
11. Watson, C.A., Petzelbauer, P., Zhou, J., Pardi, R. & Bender, J.R. (1995). Contact-dependent endothelial class II HLA gene activation induced by NK cells is mediated by IFN-γ-dependent and independent mechanisms. The Journal of Immunology 154, 3222-3233.
12. Grundt, I.K. & Nyland, H. (1992). The use of microglia activation in the evaluation of neurotoxicity. ATLA 20, 271-274
13. Grundt, I.K., Nyland, H. & Mørk, S. (1993). Protein kinase C and phagocytic activity in amitripty-line-exposed primary cultures of glial cells. ATLA 21, 181-186.
14. Loughlin, A.J., Woodroofe, M.N. & Cuzner, M.L. (1992). Regulation of Fc receptor and major histocompability complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma-induced activation. Immunology 75, 170-175.
15. Hu, S., Sheng, W.S., Peterson, P.K. & Chau, C.C. (1995). Cytokine modulation of murine microglial cell Superoxide production. GLIA 13, 45-50.
16. Streit, W.J. & Graeber, M.B. (1993). Heterogeneity of microglia and perivascular cell populations: insight gained from the facial nucleus paradigm. GLIA 7, 68-74.
17. Burger, D. & Dayer, J-M. (1995). Inhibitory cytokines and cytokine inhibitors. Neurology 45, Suppl. 6, 39-43.
18. Cuzner, M.L., Hayes, G.M., Newcombe, J. & Woodroofe, M.N. (1988). The nature of inflammatory components during demyelination in multiple sclerosis. Journal of Neuroimmunology 20, 203-209.