Heterogeneity and lability of endogenous digitalis-like substances in the plasma of the toad, Bufo marinus

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 271, Issue 2 40-2, 1996, Pages

  Butler Jr , Vincent P ^a   Morris, Jennifer F ^b   Akizawa, Toshifumi ^b   Matsukawa, Motomi ^b   Keating, Paula ^b   Hardart, Ann ^b   Furman, Inna ^b  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b NONE

Author keywords

bufadienolides; bufotoxins; Na+ K+ adenosinetriphosphatase inhibition

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; BRAIN ENZYME; BUFADIENOLIDE DERIVATIVE; BUFALIN; BUFOGENIN; CINOBUFAGIN; DIGITALIS LIKE FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CATION EXCHANGE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; FEMALE; NONHUMAN; PRIORITY JOURNAL; TOAD;

EID: 0009825352     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.271.2.r325     Document Type: Article

References (36)

1. Akizawa, T., T. Mukai, M. Matsukawa, M. Yoshioka, J. F. Morris, and V. P. Butler, Jr. Structures of novel bufadienolides in the eggs of a toad, Bufo marinus. Chem. Pharm. Bull. 42: 754-756, 1994.
2. Boulanger, B. R., M. P. Lilly, J. M. Hamlyn, J. Laredo, D. Shurtleff, and D. S. Gann. Ouabain is secreted by the adrenal gland in awake dogs. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E413-E419, 1993.
3. Chang, J.-Y., R. Knecht, and D. G. Braun. Amino acid analysis at the picomole level. Application to the C-terminal sequence analysis of polypeptides. Biochem. J. 199: 547-555, 1981.
4. +)-activated ATPase in isolated mucosal cells of toad bladder. Biochim. Biophys. Acta 249: 181-187, 1971.
5. Epstein, D. The tolerance of the toad towards strophanthin. J. Pharmacol. Exp. Ther. 43: 697-708, 1931.
6. Fieser, L. F., and M. Fieser. Cardiac-active principles. In: Steroids. New York: Reinhold, 1959, p. 727-809.
7. Flier, J. S., E. Maratos-Flier, J. A. Pallotta, and D. McIsaac. Endogenous digitalis-like activity in the plasma of the toad Bufo marinus. Nature Lond. 279: 341-343, 1979.
8. +)-ATPase from toad kidney. Biochim. Biophys. Acta 566: 157-170, 1979.
9. Goto, A., K. Yamada, N. Yagi, M. Yoshioka, and T. Sugimoto. Physiology and pharmacology of endogenous digitalis-like factors. Pharmacol. Rev. 44: 377-399, 1992.
10. Hamlyn, J. M., M. P. Blaustein, S. Bova, D. W. DuCharme, D. W. Harris, F. Mandel, W. R. Mathews, and J. H. Ludens. Identification and characterization of a ouabain-like compound from human plasma. Proc. Natl. Acad. Sci. USA 88: 6259-6263, 1991.
11. Hillman, S. S., and P. C. Withers. The hemodynamic consequences of hemorrhage and hypernatremia in two amphibians. J. Comp. Physiol. B Biochem. Syst. Environ. Physiol. 157: 807-812, 1988.
12. Höriger, N., D. Zivanov, H. H. A. Linde, and K. Meyer. Über Krotengifte. 36. Cardenolid-korksàurehalbester und weitere Bufadienolid-korksàurehalbester in Ch'an Su. Helv. Chim. Acta 53: 1993-2002, 1970.
13. Lane, L. K., J. D. Potter, and J. H. Collins. Large-scale purification of Na,K-ATPase and its protein subunits from lamb kidney medulla. Prep. Biochem. 9: 157-170, 1979.
14. +-ATPase inhibition. Heterocycles Tokyo 39: 669-686, 1994.
15. Lewis, R. P. Clinical use of serum digoxin concentrations. Am. J. Cardiol. 69: 97G-107G, 1992.
16. Lichtstein, D., I. Gati, T. Babila, E. Haver, and U. Katz. Effect of salt acclimation on digitalis-like compounds in the toad. Biochim. Biophys. Acta 1073: 65-68, 1991.
17. Lichtstein, D., I. Gati, E. Haver, and U. Katz. Digitalis-like compounds in the toad Bufo viridis: tissue and plasma levels and significance in osmotic stress. Life Sci. 51: 119-128, 1992.
18. Lichtstein, D., I. Gati, and H. Ovadia. Digitalis-like compounds in the toad Bufo viridis: interactions with plasma proteins. J. Cardiovasc. Pharmacol. 22, Suppl. 2: S102-S105, 1993.
19. Lichtstein, D., S. Kachalsky, and J. Deutsch. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative. Life Sci. 38: 1261-1270, 1986.
20. Park, Y. S., and S. K. Hong. Properties of toad skin Na-K-ATPase with special reference to effect of temperature. Am. J. Physiol. 231: 1356-1363, 1976.
21. Repke, K. Metabolism of cardiac glycosides. In: Proceedings of the First International Pharmacological Meeting. New Aspects of Cardiac Glycosides, edited by W. Wilbrandt. New York: Macmillan, 1963, vol. 3, p. 47-73.
22. Repke, K., M. Est, and H. J. Portius. Über die Ursache der Speciesunterschiede in der Digitalisempfindlichkeit. Biochem. Pharmacol. 14: 1785-1802, 1965.
23. Schoner, W. Endogenous digitalis-like factors. Clin. Exp. Hypertens. A14: 767-814, 1992.
24. Shimada, K., Y. Fujii, E. Yamashita, Y. Niizaki, Y. Sato, and T. Nambara. Studies on cardiotonic steroids from the skin of Japanese toad. Chem. Pharm. Bull. 25: 714-730, 1977.
25. Shimada, K., M. Hasegawa, K. Hasebe, Y. Fujii, and T. Nambara. Studies on steroids, CXIV. Separation of cardiotonic steroid conjugates by high-performance liquid chromatography. J. Chromatogr. 124: 79-87, 1976.
26. Shimada, K., and T. Nambara. Isolation and characterization of cardiotonic steroid conjugates from the skin of Bufo marinus (L.) Schneider. Chem. Pharm. Bull. 27: 1881-1886, 1979.
27. Shimada, K., and T. Nambara. Isolation and characterization of a new type of bufotoxin from the skin of Bufo americanus. Chem. Pharm. Bull. 28: 1559-1562, 1980.
28. +-adenosine triphos2 phatase. J. Pharmacobio-Dyn. 8: 1054-1059, 1985.
29. Shimada, K., K. Ohishi, and T. Nambara. Isolation and characterization of new bufotoxins from the skin of Bufo melanostictus Schneider. Chem. Pharm. Bull. 32: 4396-4401, 1984.
30. Shimada, K., J. S. Ro, K. Ohishi, and T. Nambara. Isolation and characterization of cinobufagin 3-glutaroyl-L-arginine ester from Bufo bufo gargarizans Cantor. Chem. Pharm. Bull. 33: 2767-2771, 1985.
31. Sokal, R. R., and F. J. Rohlf. Biometry: The Principles and Practice of Statistics in Biological Research (2nd ed.). New York: Freeman, 1981, p. 448-449.
32. +-ATPase. Biochim. Biophys. Acta 988: 185-220, 1989.
33. Toma, S., Y. Hirai, C. Sugimoto, M. Shoji, Y. Oguni, S. Morishita, C. Ito, and M. Horie. Metabolic fate of bufalin and cinobufagin. Yakugaku Zasshi 111: 687-694, 1991.
34. Verbiscar, A. J., J. Patel, T. F. Banigan, and R. A. Schatz. Scilliroside and other scilla compounds in red squill. J. Agric. Food Chem. 34: 973-979, 1986.
35. +-ATPases from skeletal and cardiac muscle and from kidney. Arch. Biochem. Biophys. 202: 442-449, 1980.
36. Woolfson, R. G., L. Poston, and H. E. de Wardener. Digoxin-like inhibitors of active sodium transport and blood pressure: the current status. Kidney Int. 46: 297-309, 1994.