Affinities of cephalosporins for penicillin-binding proteins and their antibacterial activities in the presence of human serum albumin

Clinical Microbiology and Infection

Volumn 6, Issue S3, 2000, Pages 82-83

  Fontana, R ^a   Ligozzi, M ^a   Cornaglia, G ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CEFOTAXIME; CEFTRIAXONE; HUMAN SERUM ALBUMIN; PENICILLIN BINDING PROTEIN; BACTERIAL PROTEIN; CARBOXYPEPTIDASE TRANSPEPTIDASE; CARRIER PROTEIN; CEPHALOSPORIN DERIVATIVE; GLYCOSYLTRANSFERASE; PEPTIDYLTRANSFERASE; SERUM ALBUMIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DRUG PROTEIN BINDING; ESCHERICHIA COLI K 12; NONHUMAN; DRUG EFFECT; ESCHERICHIA COLI; HUMAN; METABOLISM; MICROBIOLOGICAL EXAMINATION; PROTEIN BINDING;

BACTERIAL PROTEINS; CARRIER PROTEINS; CEFOTAXIME; CEFTRIAXONE; CEPHALOSPORINS; ESCHERICHIA COLI; HEXOSYLTRANSFERASES; HUMANS; MICROBIAL SENSITIVITY TESTS; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PROTEIN BINDING; SERUM ALBUMIN;

EID: 0009760435     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2000.tb02052.x     Document Type: Article

References (5)

1. Spratt BG. Distinct penicillin binding proteins involved in the division, elongation and shape of Escherichia coli K12. Proc Nat Acad Sci USA 1975; 72: 2999-3003.
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4. Curtis NAC, Orr D, Ross GW, Boulton MG. Competition of beta-lactam antibiotics for the penicillin-binding proteins of Pseudomonas aeruginosa, Enterobacter cloacae. Klebsiella aerogenes. Proteus rettgeri, and Escherichia coli. Comparison with antibacterial activity and effects upon bacterial morphology. Antimicrob Agents Chemother 1979; 16: 325-8.
5. Gutmann L, Vincent S, Billot-Klein D, Acar JF, Mrèna E, Williamson R. Involvement of penicillin-binding protein 2 with other penicillin-binding proteins in lysis of Escherichia coli by some beta-lactam antibiotics alone and in synergistic lytic effect of amdinocillin (mecillinam). Antimicrob Agents Chemother 1986; 30: 906-12.