Linear and cyclic peptides mimicking the disulfide loop sin HIV-2 envelope glycoprotein induced antibodies with different specificity

Molecular Immunology

Volumn 34, Issue 16-17, 1997, Pages 1177-1189

  Jrad, Besma Belhadj ^a   Bahraoui, Elmostafa ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

gp125; HIV 2ROD; Immunogenicity; Linear and cyclic peptides

Indexed keywords

CYCLOPEPTIDE; CYSTEINE; DISULFIDE; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY; PEPTIDE ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; DISULFIDE BOND; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 2; IMMUNOGENICITY; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 2; ORYCTOLAGUS CUNICULUS;

EID: 0009739331     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00120-X     Document Type: Article

References (66)

1. Ahlers, J. D., Dunlop, N., Pendleton, C. D., Newman, M., Nara, P. L. and Berzofsky, J. A. (1996) Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic T cells, and neutralizing antibody, all using the same adjuvant immunization. AIDS Rex. Hum. Retroviruses 12, 259-272.
2. Anfisen, C. B. (1973) Principles that govern the folding of protein chains. Science 181, 223-230.
3. Babas, T., Benichou, S., Guétard, D., Montagnier, L. and Bahraoui, E. (1994) Specificity of anti-peptidc antibodies produced against V2 and V3 regions of the extsrnal envelope of human immunodeficiency virus type 2. Mol. Immunol. 31, 361-369.
4. 4 receptor and role of N-glycans. AIDS Res. Hum. Retroviruses 8, 565-573.
5. Barnett, S. W., Murthy, K. K., Herndier, B. G. and Levy, J. A. (1994) An AIDS-like condition induced in baboons by HIV-2. Science 266, 642-646.
6. Belhadj Jrad, B. and Bahraoui, E. (1997) Antigenicity of linear and cyclic peptides mimicking the disulfides loops in HIV-2 envelope glycoprotein. (submitted).
7. Berzofsky, A. J., Schechter, A. N. and Kon, H. (1976) Does Freund's adjuvant denature protein antigen? EPR studies of emulsified haemoglobin. J. Immunol. 116, 270-272.
8. Björling, E., Broliden, K., Bernardi, D., Utter, G., Thorstensson, R., Chiodi, F. and Norrby, E. (1991) Hyperimmune antisera against synthetic peptides representing the glycoprotein of human immunodeficiency virus type 2 can mediate neutralization and antibody-dependent cytotoxic activity. Proc. Natl. Acad. Sci. USA 88, 6082-6086.
9. Björling, E., Chiodi, F., Utter, G. and Norrby, E. (1994) Two neutralizing domains in the V3 region in the envelope glycoprotein gp125 of HIV type 2. J. Immunol. 152, 1952-1959.
10. Boeri, E., Giri, A., Lillo, F., Ferrari, G., Varrier, A., Sabbatini, S., Saxinger, C. and Franchini, G. (1992) In vivo genetic variability of the human immunodeficiency virus type 2 V3 region. J. Virol. 66, 4546-4550.
11. Böttiger, B., Karlsson, A., Andreasson, P., Nauclér, A., Mendes Costa, C., Norrby, E. and Biberfeld, G. (1990) Envelope cross-reactivity between human immunodeficiency virus type 1 and 2 detected by different serological methods: correlation between cross-neutralization and reactivity against the main neutralizing site. J. Virol. 64, 3492-3499.
12. Braun, M. M., Heyward, W. L. and Curran, J. W. (1990) The global epidemiology of HIV infection and AIDS. Annual Review of Microbiology 44, 555-577.
13. Catasti, P., Fontenot, J. D., Bradbury, E. M. and Gupta, G. (1995) Local and global structural properties of HIV-MN V3 loop. J. Biol. Chem. 270, 2224-2232.
14. Chavez, L. G. and Scheraga, H. A. (1980) Intrinsic stabilities of portions of the ribonuclease molecule. Biochemistry 19, 1005-1012.
15. Christodoulides, M., McGuinness, B. T. and Heckels, J. E. (1993) Immunization with synthetic peptides containing epitopes of the class 1 outer-membrane protein of Neisseria meningitidis: production of bactericidal antibodies on immunization with a cyclic peptide. J. Gen. Microbiol. 139, 1729-1738.
16. Clavel, F., Guétard, D., Brun-Vézinet, F., Chamaret, S., Rey, M. A., Santos-Ferreira, M. O., Laurent, A. G., Gauguet, C., Katlama, C., Rouzioux, C., Klatzmann, D., Champalimaux, J. L. and Montagnier, L. (1986a) Isolation of a new human retrovirus from West Africa patient with AIDS. Science 233, 343-346.
17. Clavel, F., Guyader, M., Guétard, D., Sallé, M., Mantagnier, L. and Alizon, M. (1986b) Molecular cloning and polymorphism of the human immune deficiency virus type 2. Nature 324, 691-695.
18. Clavel, F., Mansinho, K., Chamaret, S., Guétard, D., Favier, V., Nina, J., Santos-Ferreira, M. O., Champalimaux, J. L. and Montagnier, L. (1987) Human immunodeficiency virus type 2 infection associated with AIDS in West Africa. N. Engl. J. Med. 316, 1180-1185.
19. DeWolf, F., Meloen, R. H., Bakker, M., Barin, F. and Goudmit, J. (1991) Characterization of human antibody-binding sites on the external envelope of human immunodeficiency virus type 2. J. Gen. Virol. 72, 1261-1267.
20. Dorow, D. S., Shi, P.-T., Carbone, F. R., Minasian, E., Todd, P. E. E. and Leach, S. J. (1985) Two large immunogenic and antigenic myoglobin peptides and the effects of cyclisation. Molecular Immunology 22, 1255-1264.
21. Ellman, G. L. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70-77.
22. Golding, H., D'Souza, M. P., Bradac, J., Mathieson, B. and Fast, P. (1994) Neutralization of HIV-1. AIDS Res. Hum. Retroviruses 10, 633-643.
23. Hanson, C. V. (1994) Measuring vaccine-induced HIV neutralization: report of a workshop. AIDS Res. Hum. Retroviruses 10, 645-648.
24. Hoxie, J. A. (1991) Hypothetical assignment of intrachain disulfide bonds for HIV-2 and SIV envelope glycoproteins. AIDS Res. Hum. Retroviruses 7, 495-499.
25. Huraux, J. M., Nicolas, J. C. and Agut, H. (1985) Titrage des virus. In Virologie ed. J. M. Huraux, J. C. Nicolas and H. Agut, pp. 56-58 Flammarion Médecine Sciences, Paris.
26. Hurrel, G. R., Smith, L. A. and Leach, S. J. (1977) Immunological measurements of conformational mobility in region of the myoglobin molecule. Biochemistry 16, 175-185.
27. Ibrahimi, I. M., Eder, J., Prager, E. M., Wilson, A. C. and Arnon, R. (1980) The effect of a single amino acid substitution on the antigenic specificity of the loop region of Lysozyme. Mol. Immunol. 17, 37-46.
28. Kanki, P., Travers, K., Mboup, S., Esieh, C.-C., Marlink, R., Guéye-Ndiaye, A., Siby, T., Thior, I., Hernandez-Avila, M., Sankalé, J.-L., Ndoye, I., Essex, M. (1994) Slower heterosexual spread of HIV-2 than HIV-1. Lancet 343, 943-946.
29. Kobs-Conrad, S., Lee, H., DiGeorge, A. M. and Kaumaya, P. T. P. (1993) Engineered topographic determinants with αβ, βαβ, and βαβα topologies show high affinity binding to native protein antigen (lactate dehydrogenase-C4). J. Biol. Chem. 1993, 25285-95.
30. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
31. Luke, W., Coulibaly, C., Dittmer, U., Voss, G., Oesterle, R., Makoschey, B., Sauermann, U., Jurkiewicz, E., StahlHennig, C., Petry, H. and Hunsmann, G. (1996) Simian immunodeficiency virus (SIV) gp130 oligomcrs protect rhesus macaques (Macaca mulatta) against the infection with SIVmac32H grown on T-cells or derived ex vivo; Virol. 216, 444-450.
32. Markert, R. L. M., Ruppach, H., Gehring, S., Dietrich, U., Mierke, D. F., Köck, M., Rübsamen-Waigmann, H. and Griesinger, C. (1996) Secondary structural elements as a basis for antibody recognition in the immunodominant region of human immunodeficiency viruses 1 and 2. Eur. J. Biochem. 237, 188-204.
33. Markovitz, D. M. (1993) Infection with the human immunodeficiency virus type 2. Ann. Intern. Med. 118, 211-218.
34. Marlink, R., Kanki, P., Thior, I., Travers, K., Eisen, G., Siby, T., Traore, I., Hsieh, C.-C., Ciré Dia, M., Gueye, E.-H., Hellinger, J., Guèye-Ndiaye, A., Sankalé, J.-L., Ndoye, I., Mboup, S. and Essex, M. (1994) Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science 265, 1587-1590.
35. Matsushita, S., Matsumi, S., Yoshimura, K., Morikita, T., Murakami, T. and Takatsuki, K. (1995) Neutralizing monoclonal antibodies against human immunodeficiency virus type 2 gp120. J. Virol. 69, 3333-3340.
36. McKnight, A., Shotton, C., Cordell, J., Jones, I., Simmons, G. and Clapham, P. R. (1996) Location, exposure, and conservation of neutralizing and non neutralizing epitopes on human immunodeficiency virus type 2 SU glycoprotein. J. Virol. 70, 4598-4606.
37. Merrifield, R. B. (1986) Solid phase synthesis. Science 232, 341-347.
38. Moore, J. P., Sattentau, Q. J., Wyatt, R. and Sodroski, J. (1994) Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies. J. Virol. 68, 469-484.
39. Muller, S., Plaué, S., Samama, J. P., Valette, M., Briand, J. P. and Van Regenmortel, M. H. V. (1990) Antigenic properties and protective capacity of a cyclic peptide corresponding to site A of influenza virus haemagglutinin. Vaccine 8, 308-314.
40. Müller, G. M., Shapira, M. and Arnon, R. (1982) Anti-influenza response achieved by immtinization with a synthetic conjugate. Proc. Natl. Acad. Sci. USA 79, 569-573.
41. Nagy, J. A., Meinwald, C. Y. and Scheraga (1982) Immunological determination of conformational equilibria for fragments of A-α chain of fibrinogen. Biochemistry 12, 1794-1806.
42. Neurath, A. R., Seto, B. and Strick, N. (1989) Antibodies to synthetic peptides from the preS. region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective. Vaccine 7, 234-236.
43. Neurath, A. R., Strick, N., Fields, R. and Jiang, S. (1991) Peptides mimicking selected disulfide loops in HIV-1 gp120, other than V3, do not elicit virus-neutralizing antibodies. AIDS Res. Hum. Retroviruses 7, 657-662.
44. Norrby, E., Putkonen, P., Böttiger, B., Utter, G. and Bibberfeld (1991) Comparison of linear antigenic sites in the envelope proteins of human immunodeficiency virus (HIV) type 2 and type 1. AIDS Res. Hum. Retroviruses 7, 279-285.
45. Novembre, F. J., Saucier, M., Anderson, D. C., Klumpp, S. A., O'Neil, S. P., Brown II, C. R., Hart, C. E., Guenthner, P. C., Swenson, R. B. and McClure, H. R. (1997) Development of AIDS in chimpanzee infected with human immunodeficiency virus I. J. Virol. 71, 4086-4091.
46. Otteken, A., Voss, G. and Hunsmann, G. (1993) Mapping of the human immunodeficiency virus type 2 envelope glycoprotein CD4 binding region and fusion domain with truncated proteins expressed by recombinant vaccinia viruses. Virol. 194, 37-43.
47. Palker, T. J., Mattews, T. J., Langlois, A., Tanner, M. E., Martin, M. E., Scearce, R. M., Kim, J. E., Berzofsky, J. A., Bolognesi, D. P. and Haynes, B. F. (1989) Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. J. Immunol. 142, 3612-3619.
48. Pepin, J., Morgan, G., Dunn, D., Gevao, S., Mendy, M., Gaye, I., Scollen, N., Tedder, R. and Whittle, H. (1991) HIV-2-induced immunosuppression among asymptomatic West African prostitutes: evidence that HIV-2 is pathogenic, but less than HIV-1. AIDS 5, 1165-1172.
49. Pfaff, E., Mussgay, M., Bohm, H. O., Schhulz, G. E. and Schaller, H. (1982) Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus. Eur. Molec. Biol. Org. J. 1, 869-874.
50. Pfutzner, A. (1991) Spread of HIV-2 in India. Lancet 337, 550-551.
51. Poulsen, A.-G., Kvinesdal, B. B., Aaby, P., Lisse, I. M., Gottschau, A., Molbak, K., Dias, F., Lauritzen, E. (1992) Lack of evidence of vertical transmission of human, immunodeficiency virus type 2 in sample of the general population in Bissau. J. Acquir. Immune Defic. Syndr. 5, 25-30.
52. Putkonen, P., Bottiger, B., Warstedt, K., Thorstensson, R., Albert, J. and Biberfeld, G. (1989) Experimental infection of cynomolgus monkeys (Macaca fascicularis) with HIV-2. J. Acquired Immune Defic. Syndr. 2, 366-373.
53. Richardson, T. M. Jr., Stryjewski, B. L., Broder, C. C., Hoxie, J. A., Mascola, J. R., Earl, P. L. and Doms, R. W. (1996) Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein. J. Virol. 70, 753-762.
54. Robert-Guroff, M., Aldrich, K., Muldoon, R., Stern, T. L., Bansal, G. P., Matthews, T. J., Marckham. P. D., Gallo, R. C. and Franchini, G. (1992) Cross-neutralization of human immunodeficiency virus type 1 and 2 and simian immunodeficiency, virus isolates. J. Virol. 66, 3602-3608.
55. Sachs, D. H., Schechter, A. N., Aestlake, A. and Anfinsen, C. B. (1972) Antibodies to a distinct determinant of staphylococcal nuclease. J. Immunol. 109, 1300-1310.
56. Satterthwait, A. C., Arrhenius. T., Hagopian, R. A., Zavala Fidel, Nussenzweig, V. and Lerner, R. A, (1988) Conformational restriction of peptidyl immunogens with covalent replacements for the hydrogen bond. Vaccine 6, 99-103.
57. Schulze-Gahmen, U., Heinrich, P., Glatter, U. and Beyreuther, K. (1985) Towards assignment of secondary structures by anti-peptide antibodies. Specificity of the immune response to a β-turn. EMBO J. 4, 1731-1737.
58. Schulze-Gahmen, U., Klenk, H.-D. and Beyreuther, K. (1986) Immunogenicity of loop-structured short synthetic peptides mimicking the antigenic site A of influenza virus hemagglutinin. Eur. J. Biochem. 159, 283-289.
59. Schwartz, O., Henin, Y., Marechal, V. and Montagnier, L. (1988) A rapid and simple colorimetric test for the study of anti-HIV agents. AIDS Res. Hum. Retroviruses 4, 441-448.
60. Scibienski, R. J. (1973) Denaturation of lysozyme by Freund's complete adjuvant. J. Immunol. 111, 114-120.
61. Shafferman, A., Jahrling, P. B., Beneviste, R. E., Lewis, M. G., Phipps, T. J., Eden-McCutchan, F., Sadoff, J., Eddy, G. A. and Burke, D. S. (1991) Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences. Proc. Natl. Acad. Sci. USA 88, 7126-7130.
62. Steimer, K. S., Scandella, C. J., Skiles, P. V., Haigwood, N. L. (1991) Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120. Science 254, 105-108.
63. Traincard, F., Rey-Cuillé, M.-A., Huon, I., Dartevelle, S., Mazié, J.-C. and Benichou, S. (1994) Characterization of monoclonal antibodies to human immunodeficiency virus type 2 envelope glycoproteins. AIDS Res. Hum. Retroviruses 10, 1659-1667.
64. Wang, C. Y., Looney, D. J., Walfield, A. M., Ye, J., Hosein, B., Tam, J. P. and Wong-Staal, F. (1991) Long-term hightiter neutralizing activity induced by octameric synthetic HIV-1 antigen. Science 254, 285-288.
65. Westhof, E., Altschuh, D., Moras, D., Bloomer, A. C., Mondragon, A., Klug, A. and Van Regenmortel, M. H. V. (1984) Correlation between segmental mobility and the location of antigenic determinants in proteins. Nature 311, 123-126.
66. Zagury, J. F., Franchini, G., Reitz, M., Collalti, E., Starcich, B., Hall, L., Fargnoli, K., Jagodzinski, L., Guo, H.-G., Laure, F., Arya, S. K., Josephs, S., Zagury, D., Wong-Staal, F. and Gallo, R. C. (1988) Genetic variability between isolates of human immunodeficiency virus (HIV) type 2 is comparable to the variability among HIV type 1. Proc. Natl. Acad. Sci. USA 85, 5941-5945.