An in vitro cell invasion assay: Determination of cell surface proteolytic activity that degrades extracellular matrix

Journal of Tissue Culture Methods

Volumn 16, Issue 3-4, 1994, Pages 177-181

  Chen, Wen Tien ^a   Yeh, Yunyun ^a   Nakahara, Hirokazu ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Extracellular matrix; Fibronectin; Invasion; Membrane protease

Indexed keywords

EID: 0009720961     PISSN: 02718057     EISSN: 15730603     Source Type: Journal    
DOI: 10.1007/BF01540646     Document Type: Article

References (9)

1. Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites
2. Local degradation of fibronectin at sites of expression of the transforming gene product pp60V-STC
3. Fibronectin-degrading proteases from the membranes of transformed cells
4. A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells
5. Membrane protease as potential diagnostic and therapeutic targets for breast malignancy
6. Protease production by cultured microglia: Substrate gel analysis and immobilized matrix degradation
7. Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins
8. The removal of extracellular fibronectin from areas of cell substrate contact