Synthesis and Anti-inflammatory and Analgesic Activities of Pyridyloxy- and Phenoxyalkanoic Acid Derivatives

Archives of Pharmacal Research

Volumn 23, Issue 1, 2000, Pages 17-21

  Shin, Kuk Hyun ^a   Lim, Soon Sung ^a   Jung, Sang Hoon ^a   Ji, Jun ^a   Lee, Eun Bang ^a   Kim, Dong Chan ^b   Shin, Kye Jung ^b   Kim, Dong Jin ^b   Park, Sang Woo ^b  

^a Seoul National University   (South Korea)

^b NONE

Author keywords

Acetic acid writhing syndrome; Analgesic activity; Anti inflammatory activity; Carrageenin induced paw edema; Phenoxylphenoxyalkanate; Pyridyloxyalkanate; Pyridyloxyphenoxyalkanate; Tail clip pressure test

Indexed keywords

ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL; ARTICLE; MALE; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0009651255     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976459     Document Type: Article

References (11)

1. Domenjoz, R., Synthetic anti-inflammatory drugs concepts of their mode of action, Adv. Pharm. 4, 143-217 (1966).
2. Etzelmillex, R.E. and Hamilton, C.S., The influence of the arsone group on the activity of nuclear chlorine, J. Am. Chem. Soc., 53, 3085 (1931).
3. Goodman, L.S. and Gilman, A., The pharmacological basis of therapeutics (Fifth ed.) Macmillan Pub. Co. Inc., p 1472-1497 (1975).
4. Hanzlik, P.J., Actions and uses of the salicylates and cinchophen in medicine, The Williams & Wilkins Co., Baltimore (1927).
5. Hench, P.S., Kendall, E.C., Slocumb, C.H. and Polley, H.S., The effect of a hormone of the adrenal cortex and of pituitary adrenocorticotropic hormone on rheumatoid arthritis, Proc. Staff Meet. Mayo Clin. 24, 181-197 (1949).
6. Lindley, J., Copper-assisted nucleophilic substitution of aryl halogen, Tetrahedron, 40, 1433-1456 (1984).
7. Mizushima, Y., Inflammation and anti-inflammatory drugs, Nankodo Ltd., p 118-120 (1968).
8. Shin, K. H., Lee, E. B., Park, S. W., Shin, K. J., Kim, D. C., Kim, D. J., Synthesis and antiinflammatory and analgesic activities of phenoxyalkanoic acid derivatives, Arch. Pharm. Res., 20, 72-75 (1997).
9. Takagi, H., Inukai, M. and Nakama, M., A Modification of Hoffners method for testing analgesics. Jpn. J. Pharmacol. 16, 287-294 (1966).
10. Whittle, B.A., The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br. J. Pharmacol. Chemother., 22, 246-252 (1964).
11. Winter, C.A., Risley, E.A. and Nuss, C.W., Carrageenininduced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med., 111, 544-548 (1962).