Sepsis is associated with increased ubiquitin-conjugating enzyme E2(14k) mRNA in skeletal muscle

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 276, Issue 2 45-2, 1999, Pages

  Hobler, Scott C ^b   Wang, Jing Jing ^b   Williams, Arthur B ^b   Melandri, Francesco ^b   Sun, Xiaoyan ^b   Fischer, Josef E ^b   Hasselgren, Per Olof ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

Cachexia; Proteasome; Proteolysis

Indexed keywords

MESSENGER RNA; UBIQUITIN CONJUGATING ENZYME;

ANIMAL EXPERIMENT; ARTICLE; CACHEXIA; ENZYME ACTIVITY; ENZYME LOCALIZATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FAST MUSCLE; IMMUNOBLOTTING; MALE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SEPSIS; TRANSCRIPTION REGULATION;

EID: 0009633961     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.2.r468     Document Type: Article

References (24)

1. Chaudry, I. H., K. A. Wichterman, and A. E. Baue. Effect of sepsis on tissue adenine nucleotide levels. Surgery 85: 205-211, 1979.
2. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
3. Ciechanover, A. The ubiquitin-proteasome proteolytic pathway. Cell 79: 13-21, 1994.
4. Clowes, G. H. A., B. C. George, C. A. Villee, and C. A. Saravis. Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma. N. Engl. J. Med. 308: 545-552, 1983.
5. Dardevet, D., C. Sornet, D. Taillandier, I. Savary, D. Attaix, and J. Grizard. Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging. J. Clin. Invest. 96: 2113-2119, 1995.
6. Goldberg, A. L. The mechanism and functions of ATP-dependent proteases in bacterial and animal cells. Eur. J. Biochem. 203: 9-23, 1992.
7. Hall-Angerås, M., U. Angerås, O. Zamir, P.-O. Hasselgren, and J. E. Fischer. Effect of the glucocorticoid receptor antagonist RU38486 on muscle protein breakdown in sepsis. Surgery 109: 468-473, 1991.
8. Hasselgren, P.-O., and J. E. Fischer. The ubiquitin-proteasome pathway: review of a novel intracellular mechanism of muscle protein breakdown during sepsis and other catabolic conditions. Ann. Surg. 225: 307-316, 1997.
9. Hasseigren, P.-O., J. H. James, D. W. Benson, M. Hall-Angerås, D. T. Hiyama, S. Li, and J. E. Fischer. Total and myofibrillar protein breakdown in different types of rat skeletal muscle: effects of sepsis and regulation by insulin. Metabolism 38: 634-640, 1989.
10. Hershko, A., and A. Ciechanover. The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61: 761-807, 1992.
11. Jentsch, S. The ubiquitin conjugation system. Annu. Rev. Genet. 26: 179-207, 1992.
12. Newsholme, E. A., and C. Start. Regulation in Metabolism. London: Wiley, 1973.
13. Pedersen, P., T. Seeman, and P.-O. Hasselgren. Protein synthesis and degradation in liver tissue following induction of septic peritonitis in rats. Acta Chir. Scand. 152: 29-34, 1986.
14. Pedersen, P., B. W. Warner, H. S. Bjornson, D. T. Hiyama, S. Li, D. F. Rigel, P.-O. Hasselgren, and J. E. Fischer. Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats. Surg. Gynecol. Obstet. 168: 148-156, 1989.
15. Price, S. R., B. K. England, J. L. Bailey, K. van Vreede, and W. E. Mitch. Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle. Am. J. Physiol. 267 (Cell Physiol. 36): C955-C960, 1994.
16. Rosenblatt, S., G. H. A. Clowes, B. C. George, E. Hirsch, and B. Lindberg. Exchange of amino acids by muscle and liver in sepsis. Arch. Surg. 118: 167-175, 1983.
17. Temparis, S., M. Asensi, D. Taillandier, E. Aurousseau, D. Larbaud, A. Obled, D. Béchet, M. Ferrara, J. M. Estrela, and D. Attaix. Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats. Cancer Res. 54: 5568-5573, 1994.
18. Tiao, G., J. M. Fagan, V. Roegner, M. Lieberman, J. J. Wang, J. E. Fischer, and P.-O. Hasselgren. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J. Clin. Invest. 97: 339-348, 1996.
19. Tiao, G., J. M. Fagan, N. Samuels, J. H. James, K. Hudson, M. Lieberman, J. E. Fischer, and P.-O. Hasselgren. Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. J. Clin. Invest. 94: 2255-2264, 1994.
20. Tiao, G., S. Hobler, J. J. Wang, T. A. Meyer, F. A. Luchette, J. E. Fischer, and P.-O. Hasselgren. Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J. Clin. Invest. 99: 163-168, 1997.
21. Tiao, G., M. Lieberman, J. E. Fischer, and P.-O. Hasselgren. Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R849-R856, 1997.
22. Wing, S. S., and D. Banville. 14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E39-E48, 1994.
23. Wing, S. S., and N. Bedard. Insulin-like growth factor I stimulates degradation of an mRNA transcript encoding the 14 kDa ubiquitin-conjugating enzyme. Biochem. J. 319: 455-461, 1996.
24. Zamir, O., P.-O. Hasselgren, J. A. Frederick, and J. E. Fischer. Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats. J. Pediatr. Surg. 27: 1399-1403, 1992.