Nutritionally induced insulin resistance in Psammomys obesus, its consequences and its possible prevention

Experimental and Clinical Endocrinology and Diabetes

Volumn 105, Issue SUPPL. 3, 1997, Pages 12-13

  Ziv, Ehud ^a   Nachliel, Idith ^a   Bar On, Hanoch ^a   Shafrir, Eleazar ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0009587942     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211823     Document Type: Conference Paper

References (8)

1. Shafrir E, Gutman A. Psammomys obesus of the Jerusalem colony: a model for nutrtionally induced, non-insulin dependent diabetes. J Basic Clin Physiol Pharmacol 4: 83-99, 1993
2. Ziv E, Shafrir E. Psammomys obesus: nutritionally induced NEDDM-like syndrome on a "thrifty" gene background. Lessons from Animal Diabetes, (E. Shafrir ed.) Smith-Gordon, London 5: 285-300, 1995
3. Kanety H, Moshe S, Shafrir E, Lunenfeld B, Karasik A. Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin dependent diabetes. Proc Natl Acad Sci USA 91: 1853-1857, 1994
4. Ziv E, Kalman R, Hershkop K, Barash V, Shafrir E, Bar-On H. Insulin resitance in the NIDDM model Psammomys obesus in the normoglycaemic, normoinsulinaemic state. Diabetologia 39: 1269-1275, 1996
5. Takayama S, White MF, Kahn CR. Phorbolester induced serine phophorylation of the insulin receptor decreases tyrosine kinase activity. J Biol Chem 263: 3440-3447, 1988
6. Balta Y, Ziv E, Kalman R, Sack J, Shemer J, Shafrir E, Meyerovitch J. Psammomys obesus, a model of nutritionally induced diabetes mellitus is grossly deficient of both receptor-like protein tyrosine phosphatase LAR and insulin receptor. Isr J Meed Sci 33: S10, 1997
7. Berti L, Mosthaf L, Kroder G, Kellerer M, Tippmer S, Mushack J, Seffert E, Seedorf K, Haring H. Glucose-induced translocation of protein kinase isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. J Biol Chem 269: 3381-3386, 1994
8. Schmitz Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ. Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46: 169-178, 1997