Pharmacokinetics in vivo and in vitro in swine

Scandinavian Journal of Laboratory Animal Science

Volumn 25, Issue SUPPL. 1, 1998, Pages 45-56

  Witkamp, Renger F ^a,b   Monshouwer, Mario ^b  

^a TNO   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

SUS SCROFA;

EID: 0008956682     PISSN: 09013393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Abdel-Razzak, Z, P Loyer, A Fautrel, JC Gautier, L Corcos, B Turlin, P Beaune, & A Guillouzo: Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol. Pharmacol. 44: 707-715,1993.
2. Anadon, A, MR Martinez-Larrañaga, MJ Diaz, R Fernandez, MA Martinez & MC Fernande: Pharmacokinetics and tissue residues of norfloxacin and its N-desethyl- and oxo-metabolites in healthy pigs. J.Vet.Pharmacol.Therap. 18:220-225, 1995.
3. Aoyagi N, H Ogata, N Kaniwa, M Uchiyama, Y Yasuda & Y Tanioka: Gastric emptying of tablets and granules in humans, dogs, pigs and stomach-emptying-controlled rabbits. J.Pharm. Sci. 81: 1170-1174, 1992.
4. Baggot, JD: Principles of drug disposition in domestic animals. Saunders, 1977
5. Bailie MB, Federowicz DA, Dolce, K, Kahn C, Mico, BA & Landi, MS: Pharmacokinetics of aceta-minophen, vancomycin, and antipyrine in the Hanford miniature swine. Drug Metabol. Disp. 15: 729-730, 1987
6. 14C]Phenol in various species. Xenobiotica, 2 : 25-34, 1972.
7. Dolphin, C, EA Shepard, S Povey, CNA Palmer, DM Ziegler, R Ayesh, RL Smith & IR Phillips: Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO). J. Biol. Chem. 266 : 12379-12385, 1991.
8. Dressman, JB & K Yamada: Animal models for oral drug absorption. In : Pharmaceutical Bioequivalence, Welling P.G., Tse, F.L.E, and Gihe, S.V. (eds.). Drugs and the pharmaceutical sciences, chapter 9, Vol 48, Marcel Dekker Inc. New York (ISBN 0-8247-8484-7), 1991
9. th edition). Merck & Co, 1986.
10. Friis, Ch, Gyrd-Hansen N, Nielsen P, Olsen C-E, & Rasmussen F: Pharmacokinetics and metabolism of sulphadiazine in neonatal and young pigs. Acta Pharmacol. Toxicol. 54: 321-326, 1984.
11. Guillouzo, A: Use of isolated and cultured hepatocytes for xenobiotic metabolism and cytotoxicity studies. In: Research in isolatedn and cultured hepatocytes. (Eds. Guillouzo A and Guguen-Guillouzo C) John Libbey, London, 313-332, 1986.
12. Gyrd-Hansen N, L Brimer & F Rasmussen: Percutaneous absorption of organophosphorus insecticides in pigs-the influence of different vehicles. J.vet.Pharmacol.Ther. 16: 174-80, 1993.
13. Hoogenboom, LAP, FJH Pastoor, WE Clous, SE Hesse, & HA Kuiper: The use of porcine hepatocytes for biotransformation studies of veterinary drugs, Xenobiotica. 19: 1207-1209, 1992.
14. Hoogstraate, AJ, JC Verhoef, B Tuk, A Pijpers, LAMG van Leengoed, JHM Verheijden, HE Junginger & HE Boddé: In vivo buccal delivery of fluorescein isothiocyanate-dextran 4400 with glycodeoxycholate as an absorption enhancer in pigs. J.Pharm. Sci. 85 : 457-460,1996b.
15. Hoogstraate, AJ, JC Verhoef, A Pijpers, LA van Leengoed, JHM Verheijden, HE Junginger & HE Boddé: In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs. Pharm-Res. 13: 1233-1237,1996a
16. Hucker, HB Animal Species: In: Drug fate and metabolism Vol4, Eds Garrett ER & Hirtz JL M Dekker, New York/Basel, chapter 5, 335-385, 1983.
17. Jehl, F, L Bresler, C Koechlin, M Merle-Melet, JP Didelot & J Hazebroucq: Pharmacokinetics and biliary elimination of temafloxacin in pigs. J.Antimicrob.Chemother. 30 : 189-196, 1992.
18. Jørgensen, A, Christrup, LL, Fullerton, A, Christensen, CB & H Bundgaard: Prolonged release from the injection site of morphine from morphine esters in oil vehicle given by intra-muscular injection to pigs. Pharm. Toxicol. 75:319-320, 1994.
19. Kabanda, L, RA Lefebvre, HJ van Bree & J-P Remon: In vitro and in vivo evaluation in dogs and pigs of a hydrophilic matrix containing propylthiouracil. Pharm. Res. 11 : 1663-1668, 1994
20. Kadir, F, J Zuidema, A Pijpers, A Vulto & JHM Verheijden: Drug lipohilicity and release pattern of some β-blocking agents after intra-adipose and intramuscular injection in pigs. Int. J. Pharm. 64:171-180, 1990.
21. Kamimori, GH, RW Hoyt, ND Eddington, PM Young, MJ Burkot, VA Forte, AE Brunhart, S Lugo & A Cymerman: Effects of chronic hypoxia on the pharmacokinetics of caffeine and cardio-green in micro swine. Aviat., Space Environ. Med. 66 : 247-250, 1995.
22. Krishnana, TR, I Abraham & S Craig: Use of domestic pig as a model for oral bioavailability and pharmacokinetic studies. Biopharm.Drug Disposit. 15 : 341-346,1994.
23. Mammen GJ (ed.): Clinical Pharmacokinetics. Drug Data Handbook. Adis Press, 1990.
24. Merle-Mekt M, L Bresler, J-P Didelot, F Jehl, A Gerard & P Biossel: A surgical model for studying excretion of drugs in the awake micropig yucatan. J. Exp. Anim. Sci. 36:201-208, 1994.
25. Monshouwer, M, RF Witkamp, SM Nijmeijer, A Pijpers, JHM Verheijden, & ASJPAM van Miert: Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig. Xenobiotica 25: 491-499, 1995a
26. Monshouwer, M, RF Witkamp, SM Nijmeijer, LAMG van Leengoed, J.H.M. Verheijden, & ASJPAM van Miert: Infection (Actinobacillus pleuropneumoniae) mediated suppression of oxidative hepatic drug metabolism and cytochrome P4503A mRNA levels in pigs. Drug Metabol. Disp. 23: 44-47, 1995b.
27. Monshouwer, M, RF Witkamp, SM Nijmeijer, JG van Amsterdam, & ASJPAM van Miert: Suppression of cytochrome P450- and UDP glucuronosyl transferase dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes. Toxicol. Appl. Pharmacol. 137: 237-244, 1996a
28. Monshouwer, M, RF Witkamp, SM Nijmeijer, LAMG van Leengoed, HCM Vernooy, JHM Verheijden, & ASJPAM van Miert: A lipopolysaccharide induced acute phase response in the pig inhibits hepatic cytochrome P-450 mediated drug metabolism. J. vet. Pharmacol. Therap. 19: 382-388, 1996b.
29. Nebert, DW, DR Nelson & R Feyereisen, R: Evolution of the cytochrome P450 genes. Xenobiotica, 19: 1149-1160, 1989.
30. Nelson, DR, T Kamataki, DJ Waxman, FP Guengerich, RW Estabrook, R Feyereisen, FJ Gonzalez, MJ Coon, IC Gunsalus, O Gotoh, O Okuda, & DW Nebert: The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes and nomenclature. DNA and Cell Biology, 12 : 1-51, 1993.
31. Nouws, JFM, D Mevius, TB Vree & M Degen: Pharmacokinetics and renal clearance of sulphadimidine, sulphamerazine, and sulphadiazine and their N4-acetyl and hydroxy metabolites in pigs. Vet Q. 11 : 78-86, 1989.
32. Oberle, RL, H Das, SL Wong, KKH Chan & RJ Sawchuk: Pharmacokinetics and metabolismof diclofenac sodium in Yucatan miniature pigs. Pharm. Res. 11 5 : 698-703, 1994
33. Paine, AJ: The maintenance of cytochrome P450 in rat liver hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P450 system. Chem. Biol. Interactions 74: 1-31, 1990.
34. Pijpers, A, EN Noordhuizen-Stassen, SA Goedegebuure, OA van Dobbenburgh, M Roosendaal, AHM Cornelissen & JHM Verheijden: Intravenous catheterisation of conventional pigs without application of antimicrobial agents. Vet Quart 11 : 216-221,1989
35. Qiao, G.L., P.L. Williams & J.E. Riviere: Percutaneous absorption, biotransformation, and systemic disposition of parathion in vivo in swine. I. Comprehensive pharmacokinetic model. Drug Metab. Dispos. 22: 459-71, 1994.
36. Renton, K.W., & L.C. Knickle: Regulation of hepatic cytochrome P450 during infectious disease. Can. J. Physiol. Pharmacol. 68: 777-781, 1990.
37. Riviere, J.E., K.F. Bowman, N.A. Monteiro-Riviere, L.P. Dix & M.P. Carver: The isolated perfused skin flap (IPPSF). I. A novel in vitro model for percutaneous absorption and cutaneous toxicity studies. Fundam. Appl. Toxicol. 7: 444-453, 1986.
38. Salmon, J., D. Levêque, J.D. Peter, A Cavalier, H. Elkhaïli, Y. Salmon, G. Kaltenbach, H. Monteil & F. Jehl: Modèle de porc miniature cathétérisé pour les études pharmacocinétiques et pharmacodynamiques des agents antiinfectieux. Path. Biol. 44 : 375-378, 1996.
39. Seglen, P.O.: Preparation of isolated liver cells. Methods Cell. Biol. 13: 29-83, 1976.
40. Smith, D.A.: Species differences in metabolism and pharmacokinetics: are we close to an understanding? Drug metabol rev 23, 355-373, 1991
41. Svendsen O., L. Blom, T. Aaes-Jargensen & J.J. Larsen: Local toxicity of different drugs after intramuscular or intralipomtous injection in pigs: serum concentrations after three different preparations of cis(Z)-clopenthixol. Acta pharmacol. toxicol. 57:78-87, 1985.
42. Swagler, A.R., M. Qian & J.M. Gallo: Pharmacokinetics of anti-HIV nucleosides in microswine. J. Pharm. Pharmacol 43: 823-826, 1991.
43. Teunissen, M.W.A, A.K. Srivastava & D.D. Breimer: Influence of sex and oral contraceptive steroids on antipyrine metabolite formation. Clin. Pharmacol.Ther. 32 : 240-246, 1982.
44. Timbrell, J.A: Principles of Biochemical Toxicology, Taylor and Francis, 1991
45. van Leeuwen. P., D.J. van Kleef, G.J.M. van Kempen, J. Huisman & M.W.A. Verstegen: The post valve T-caecum cannulation technique in pigs applicated to determine the digestability of maino acids in maize, groundnut and sunflower meal. J. Anim. Physiol. Anim. Nutr. 65 : 183-193,1991.
46. 2, pH, urea, ammonia, and creatinine and proteins in portal and arterial blood measured in pigs. J. Anim. Physiol. Anim. Nutr. 73 : 38-46, 1995.
47. van de Sandt, J.J.M., A.A.J.J.L. Rutten & B. van Ommen: Species-specific cutaneous biotransformation of the pesticide propoxur during percutaneous absorption in vitro. Toxicol. Appl. Pharmacol. 123 : 144-150, 1993
48. van Kleef, D.J., K. Deuring & P. van leeuwen: A new method of faeces collection in the pig. Laboratory animals 28: 78-79, 1994.
49. Van den Broek, J.M., M.W.E. Teunissen & D.D. Breimer: Induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the pig. Drug Metabol Disp 9 : 541-544, 1981.
50. Vesell E.S., C.J. Lee, G.T. Passananti & C.A. Shively: Relationship between plasma antipyrine half-lives and hepatic drug metabolism in dogs. Pharmacology 10:317-328, 1973.
51. Vickers, F.F., T.A. Bowman, B.H. Dvorchik, G.T. Passananti, D.M. Hughes & E.S. Vesell: On the antipyrine test in laboratory animals. Studies in the dog and monkey. Drug. Metabol. Dispos. 17:160-165, 1989.
52. Vree, T.B. & Y.A. Hekster: Pharmacokinetics of sulfonamides revisited. Antibiotics and Chemotherapy 34, 1985
53. Watkins, J.B. & C.D. Klaassen: Xenobiotic biotransformation in livestock: comparison to other species commonly used in toxicity testing. J.Anim.Sci.63:933-942, 1986.
54. Weber, W.W., & I.B. Glowinski: Acetylation. In Enzymatic basis of Detoxication Vol II. Ed: Jakoby W.B. Academic Press, New York: pp 169-186, 1980.
55. Witkamp, R.F., J.A.C.M. Lohuis, S.M. Nijmeijer, H.J. Kolker, J. Noordhoek, & A.S.J.P.A.M. van Miert: Species-and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species : cattle, goat, rat and rabbit. Xenobiotica 21: 1483-1492, 1991.
56. Witkamp R.F., S.M. Nijmeijer, M. Monshouwer, & A.S.J.P.A.M. van Miert: The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Drug Metabol. Dispos. 23 : 1-6, 1995.
57. Ziegler, D.M.: Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity. TiPS 11: 321-324, 1990.
58. Ziegler, D.M.: Flavin-containing monooxygenase: catalytic mechanisms and substrate specificities. Drug Metabol. Rev. 19: 1-32, 1988.